Abstract：
:The enterohepatic circulation and metabolism of ethynodiol diacetate (3beta,17beta-diacetoxy-17alpha-ethynyl-estr-4-ene) in baboons were studied following the intravenous injection of this contraceptive steroid labeled with 14C (4-position) and with 3H (in either the 3- or 17-acetoxy moieties). Bile and urine from four baboons with biliary fistulas and urine from four intact baboons were collected for 7 hours. On the average, 40% and 44% of the injected dose were excreted in the bile and urine, respectively. Only 48% was recovered in the urine of intact baboons. Analysis of these excretion rates indicates an insignificant enterohepatic circulation of this compound. The steroid was excreted mostly (over 80%) as a glucosiduronate in urine and bile. Very little excretion of the 3-acetoxy compound was detected in the urine or bile at any time interval. 17-Monoacetoxy compounds, however, were detected both in urine and bile, suggesting a difference in the rate of in vivo hydrolysis of the 17beta- vs. the 3beta-acetate.
journal_name
Steroidsjournal_title
Steroidsauthors
Ishihara M,Osawa Y,Kirdani RY,Sandberg AAdoi
10.1016/0039-128x(75)90048-3subject
Has Abstractpub_date
1975-06-01 00:00:00pages
829-47issue
6eissn
0039-128Xissn
1878-5867pii
0039-128X(75)90048-3journal_volume
25pub_type
杂志文章相关文献
STEROIDS文献大全abstract：:Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cell...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2008.11.017
更新日期：2009-07-01 00:00:00
abstract：:Five new steroidal alkaloids, 5,14-dehydro-N(a)-demethylsaracodine [3beta-N(a)-methyl-20S-N(b)-acetyl-N(b)-methylamino-pregn-5,14-diene] (1), 14-dehydro-N(a)-demethylsaracodine [3beta-N(a)-methyl-20S-N(b)-acetyl-N(b)-methylamino-5alpha-pregn-14-ene] (2), 16-dehydrosarcorine [(20S)-20-(N,N-dimethylamino)-3beta-(N(a)-ac...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.03.016
更新日期：2004-10-01 00:00:00
abstract：:Due to their high profile biological activity, the steroids are among the most important secondary metabolites. A review of literature on the synthesis of pentacyclic steroids is presented. ...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2008.04.005
更新日期：2008-09-01 00:00:00
abstract：:Postmitochondrial supernatant (PMS) (1) has been prepared from the homogenate of rat seminal vesicles and the characteristics of the binding reaction of 5alpha-dihydrotestosterone (DHT) to the cytoplasmic androgen receptor have been studied using a charcoal adsorption procedure. At 0 degrees C apparent equilibrium of ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(77)80021-4
更新日期：1977-12-01 00:00:00
abstract：:A time course study to measure adrenal cortical function was undertaken for the period prior to the development of hypertension until the onset of hypertension in the adrenal-regeneration hypertension (ARH) model. Quiescent rat kills were used so that all adrenal cortical parameters investigated would reflect basal or...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(75)90090-2
更新日期：1975-03-01 00:00:00
abstract：:Bile acid derivatives, with and without C-3 sulfate groups, and having either the diazo- or halomethylketone moieties, have been synthesized in good yield and purity. The synthetic sequence, COOH leads to COC1 leads to COCHN2 leads to COCH2X, was used with deoxycholic and cholic acids, which requires carefully control...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(79)90046-1
更新日期：1979-08-01 00:00:00
abstract：:Contrary to the long-held postulate of steroid-hormone binding globulin action, these protein carriers of steroids are major players in steroid actions in the body. This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are act...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.11.010
更新日期：2014-03-01 00:00:00
abstract：:In our effort to develop imaging agents for brain glucocorticoid receptors, we have prepared several novel glucocorticoids possessing a 2-methylsulfanyl-acetyl side chain. The synthesis was accomplished via a Mitsunobu reaction with thiobenzoic acid starting from cortisol, prednisolone, dexamethasone and triamcinolone...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2007.08.013
更新日期：2008-01-01 00:00:00
abstract：:The uterine milk (UTM) proteins are the major progesterone-regulated proteins secreted by the sheep uterus during pregnancy. Recently, proteins related to the UTM proteins have been identified in uterine secretions of the pregnant cow and sow. The present objective was to determine the time course for induction of the...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(91)90022-n
更新日期：1991-12-01 00:00:00
abstract：:This report details the synthesis of 1) 3,4,4'-trihydroxy-alpha, alpha'-diethyl-trans-stilbene; 2) 3,4-bis-(p-hydroxyphenyl)-trans-3-hexenol; 3) 3,4-bis-(p-hydroxyphenyl)-2,4-cis,cis-hexadienol; 4) 3,4-bis-(3'-methoxy-4'-hydrophenyl)-trans-3-hexene; 5) 3,4-bis-(3',4'-dimethoxyphenyl)-trans-3-hexene. These compounds ar...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(81)90304-4
更新日期：1981-03-01 00:00:00
abstract：:Nine new steroidal glycosides, named as stauntosides C-K (2, 5, 7-10, 13, 14, and 16), along with seven known compounds (1, 3, 4, 6, 11, 12, and 15) were isolated from the 95% ethanol extract of the roots of Cynanchum stauntonii. The structures of these new compounds were elucidated on the basis of extensive spectrosc...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.10.007
更新日期：2013-01-01 00:00:00
abstract：:20S-hydroxyvitamin D3 (20S-(OH)D3), an in vitro product of vitamin D3 metabolism by the cytochrome P450scc, was recently isolated, identified and shown to possess antiproliferative activity without inducing hypercalcemia. The enzymatic production of 20S-(OH)D3 is tedious, expensive, and cannot meet the requirements fo...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2010.05.021
更新日期：2010-12-01 00:00:00
abstract：:As demonstrated for pregnenolone, saturated ketones are conveniently alpha-hydroxymethylated by their transformation into a lithium enolate and by the reaction of the latter with formaldehydr. The 17-hydroxymethylpregnenolone prepared by this method in very good yield was readily converted to 17-hydroxymethylprogester...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(79)80021-5
更新日期：1979-11-01 00:00:00
abstract：:Estradiol benzoate (EB) has been one of the most widely used estrogenic agents in animal husbandry, as a way of exogenously introducing the natural hormone estradiol-17β into the animal organism. Estradiol was previously employed to induce anabolic effects or reproductive improvements in cattle. However, the employmen...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2010.12.005
更新日期：2011-03-01 00:00:00
abstract：:The chemoselectivity of rigid cyclic alpha,beta-unsaturated carbonyl group on the reducing agents was influenced by the ring size and steric factor. Cholesterol (cholest-5-en-3beta-ol) and dehydroepiandrosterone (DHEA) were oxidized with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form 1,4,6-cholestatrien-3-one and 1...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2006.12.008
更新日期：2007-04-01 00:00:00
abstract：:Breast cancer risk is strongly related to several reproductive and hormonal factors, but the nature of the effects of endogenous oestrogens has been difficult to establish. Data are now available from several large prospective studies with biobanks of stored serum, enabling better characterization of the associations ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.02.029
更新日期：2011-07-01 00:00:00
abstract：:The preparation of 3-oxo-4-azasteroid from A-nor-3,5-secosteroid-3-oic acid is described in a solventless condition catalysed by Lewis acid under microwave irradiation. We utilized urea as an environmentally benign source for the generation of ammonia for the aza cyclization reaction. ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2008.01.022
更新日期：2008-07-01 00:00:00
abstract：:Traditional interpretation of GC-MS output involved the semi-quantitative estimation of outstanding low or high specific metabolites and the ratio between metabolites. Here, we utilize a systems biology approach to steroid metabolomics of a complex steroid-related disorder, using an all-inclusive analysis of the stero...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2014.07.003
更新日期：2014-10-01 00:00:00
abstract：:The purpose of this study was to investigate the influence of plasma steroid-binding proteins on androgen metabolism in intact leukocytes prepared from normal male and female blood samples. Leukocyte preparations were incubated for 24 h at 37 degrees C with either labeled or unlabeled testosterone (T), 5 alpha-dihydro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(94)00042-b
更新日期：1995-02-01 00:00:00
abstract：:The adverse effects of hypercortisolism on the human brain have been highlighted in previous studies of Cushing's disease (CD). However, the reversibility of brain damage after the resolution of hypercortisolism remains unclear. Thus, we studied the potential volumetric reversibility in biochemically remitted CD patie...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2019.108457
更新日期：2019-11-01 00:00:00
abstract：:A novel steroid, 1alpha,3beta,5beta-trihydroxy-24-methylenecholestan-6-one (gibberoketosterol) (1), along with four known steroids, was isolated from the lipophilic extracts of a Taiwanese soft coral Sinularia gibberosa. The structure of the new metabolite was determined on the basis of extensive spectral analyses and...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(03)00036-9
更新日期：2003-04-01 00:00:00
abstract：:Preparative chemical methods for the synthesis of eight oxidative transformation products of ethinyl estradiol (EE) and norethindrone acetate (NA) are described. The prepared materials are useful as reference materials and standards for pharmaceutical analysis of EE and NA as bulk chemical or in formulated product. Al...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(01)00149-0
更新日期：2002-03-01 00:00:00
abstract：:Reaction kinetics of the aromatase enzyme and of a new nonsteroidal aromatase inhibitor, R 76 713 (6-[(4-chlorophenyl)(1H-1,2,4-triazol-1-yl)-methyl]-1-methyl-1H- benzotriazole), were studied in ovarian homogenates obtained from pregnant mare's serum gonadotropin (PMSG)-injected female Wistar rats. The Km (Michaelis c...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(90)90027-9
更新日期：1990-02-01 00:00:00
abstract：:Effective syntheses of endo- and exocyclic alpha,beta-unsaturated ketones as CC dipolarophiles were carried out in the 13alpha-estrone series. The 1,3-dipolar cycloadditions of 15,16alpha,beta-unsaturated ketones of 13alpha-estrone 3-methyl and 3-benzyl ether with nitrilimines stereoselectively furnished two regioisom...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2009.02.001
更新日期：2009-06-01 00:00:00
abstract：:Recent studies have suggested that progestins play a role in the etiology of breast cancer; however, the mechanisms by which progestins promote tumor formation/progression have not been defined. Progestin action, in target tissues such as the breast, is mediated by the progesterone receptor (PR). PR signaling is compl...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.12.014
更新日期：2013-06-01 00:00:00
abstract：:Steroids have been shown to have multiple effects on the nervous system including neuroprotective activities, and they have the potential to be used for the treatment of neurodegenerative diseases. In this current study, we tested the hypothesis that the marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol (Tetro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2015.11.005
更新日期：2016-01-01 00:00:00
abstract：:Glucocorticoids (GCs) and progesterone have been employed as immunosuppressive agents during pregnancy for many years. Intracellular acidification by GCs is due to a rapid non-genomic inhibition of membrane Na(+)/H(+)-exchange 1 (NHE1) activity and is followed by immunosuppression of PHA-stimulated proliferation. NHE1...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2016.01.004
更新日期：2016-07-01 00:00:00
abstract：BACKGROUND:Adiponectin, an insulin-sensitive hormone that is primarily synthesized in adipose tissue, exerts its effects by binding to two receptors, adipoR1 and adipoR2. Little is known regarding the effects of glucocorticoids on the expression of adiponectin receptors. METHODS:Male Wistar rats were bilaterally adren...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.06.004
更新日期：2011-11-01 00:00:00
abstract：:Ethynylestradiol (EE2) is one of the most potent endocrine disrupting compounds capable to induce estrogenic effects even at trace level concentrations in the aquatic environment. Methods for detecting EE2 in such concentrations are generally based on GC or HPLC coupled to at least one mass spectrometer. Another appro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.01.003
更新日期：2004-04-01 00:00:00
abstract：:The characterization of new conjugated vitamin D metabolites in rat bile was performed using HPLC, liquid chromatography/tandem mass spectrometry combined derivatization, and GC-MS. After the administration of 24,25-dihydroxyvitamin D(3) to rats, 23, 25-dihydroxy-24-oxovitamin D(3) 23-glucuronide, 3-epi-24, 25-dihydro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(00)00087-8
更新日期：2000-05-01 00:00:00
