Reversible and the irreversible structural alterations on brain after resolution of hypercortisolism in Cushing's disease.

abstract：:The luteinizing hormone (LH) surge initiates a cascade of proteolytic events that control ovulation. One of the genes induced by LH is the progesterone receptor (PR). Because mice with a mutant PR gene (PRKO) fail to ovulate and are infertile, we have used them as a model in which to determine PR target genes that mig...

journal_title：Steroids

authors： Robker RL,Russell DL,Yoshioka S,Sharma SC,Lydon JP,O'Malley BW,Espey LL,Richards JS

更新日期：2000-10-01 00:00:00

abstract：:Brassinosteroids (BRs) control several important agronomic traits, such as strengthening resistance to diverse adversity, improving the quality, and increasing crop yield. Their chemical structures and varieties, specific methods for the evaluation of bioactivities, structure-activity relationships, potential novel co...

journal_title：Steroids

authors： Liu J,Zhang D,Sun X,Ding T,Lei B,Zhang C

更新日期：2017-08-01 00:00:00

abstract：:Inhibitors of estrogen 2-hydroxylase can be utilized in studying the kinetics of this cytochrome P450 enzyme complex and in elucidating the structural requirements of the active site. The conversion of estrogens to 2-hydroxyestrogens in rat liver microsomal preparations was examined using two radiotracer assays, the c...

journal_title：Steroids

authors： Brueggemeier RW,Kimball JG

更新日期：1983-07-01 00:00:00

abstract：:The use of steroid hormones as growth promoters remains illegal in Europe. A classical approach used to control their utilization consists to measure the parent drug in target biological matrices. However, this strategy may fail when the parent drug is submitted to extensive metabolism reactions. For urine and tissue ...

journal_title：Steroids

authors： Antignac JP,Brosseaud A,Gaudin-Hirret I,André F,Bizec BL

更新日期：2005-03-01 00:00:00

abstract：:Chick kidney and brain were analyzed for the subcellular distribution (if any) of a putative plasma membrane receptor for 1,25-dihydroxyvitamin D3 [1,25(OH)2D3]. Fractionation protocols were found to be based not only on differential centrifugation conditions, but also gentleness of resuspension procedures, and suffic...

journal_title：Steroids

authors： Jia Z,Nemere I

更新日期：1999-08-01 00:00:00

abstract：:4- to 8-cell mouse PIE's (preimplantation embryos) were cultured in vitro for 48 hr in media containing various concentrations of the anti-estrogen CI-628. Graded effects of the various concentrations were observed with the highest concentration (1.5 microng/ml) being 100% effective in blocking development to the blas...

journal_title：Steroids

authors： Gupta JS,Dey SK,Dickmann Z

更新日期：1977-03-01 00:00:00

abstract：:Homogenates from human myometrium with an added NADPH regenerating system and ATP were incubated with 4-(14)C progesterone. Six metabolites were identified: 5alpha-pregnane-3, 20-dione, 5beta-pregnane-3, 20-dione, 3alpha-hydroxy-4-pregnen-20-one, 3beta hydroxy-4-pregnen-20-one. 20alpha-hydroxy-4-pregnen-3-one and 20be...

journal_title：Steroids

authors： Junkermann H,Runnebaum B,Lisboa BP

更新日期：1977-07-01 00:00:00

abstract：:We have previously shown that the photoactive 4-azasteroid, [1,2 3H]N-4(benzylbenzoyl)-3-oxo-4-aza-4-methyl-5alpha-androst an-17beta-carboxamide is an effective probe of rat steroid 5alpha-reductase (isozyme-1) (5alphaR-1). In the current investigation, PEG-fractionated (6.5%) detergent-solubilized preparations contai...

journal_title：Steroids

authors： Bhattacharyya AK,Wang M,Rajagopalan K,Taylor MF,Hiipakka R,Liao S,Collins DC

更新日期：1999-03-01 00:00:00

abstract：:Some intermediates in the cholesterol biosynthesis between lanosterol and cholesterol are capable of inducing resumption of meiosis in cultured mouse oocytes without the presence of gonadotropins. The mechanism by which these so-called Meiosis Activating Sterols (MAS) activate the meiotic process is unknown, and it is...

journal_title：Steroids

authors： Yding Andersen C,Byskov AG

更新日期：2002-11-01 00:00:00

abstract：:Optimal assay conditions for cholesterol 7 alpha-hydroxylase activity in swine liver microsomes were determined. The enzyme activity is induced three-fold by feeding cholestyramine to the swine. This suggests that cholesterol 7 alpha-hydroxylase is likely to be the rate-limiting enzyme for biosynthesis of bile acids i...

journal_title：Steroids

authors： Li JR,Kim DN

更新日期：1979-03-01 00:00:00

abstract：:A convenient procedure for the synthesis of 5 beta-cholestane-3 alpha,7 alpha,12 alpha,25-tetrol via a modified homologation sequence of the intermediate 3 alpha,7 alpha,12 alpha-triformyloxy-24-oxo-25-diazo-25-homo-5 beta-cholane involving a homogeneous medium is described. This involves treating the intermediate alp...

journal_title：Steroids

authors： Dayal B,Bagan E,Speck J,Salen G

更新日期：1980-04-01 00:00:00

abstract：:Kyotorphin (KTP, H-Tyr-Arg-OH) was covalently bonded with hydrocortisone or estrone to form the corresponding hydrocortisone-21-O-yl-succinyl-Tyr-ArgOH or estrone-3-O-yl-acyl-Tyr-Arg-OH. Their analgesic activities were investigated using the tail flick test. The potency of the two linkers were significantly higher tha...

journal_title：Steroids

authors： Wang C,Zhao M,Yang J,Peng S

更新日期：2001-11-01 00:00:00

abstract：:The mechanism accounting for the development of castration-resistant prostate cancer (CRPC) remains unclear. Studies in CRPC tissues suggest that, after androgen deprivation therapy (ADT), the adrenal androgens may be an important source of testosterone (T) and 5-alpha dihydrotestosterone (DHT) in CRPC tissues. To cla...

journal_title：Steroids

authors： Arai S,Miyashiro Y,Shibata Y,Tomaru Y,Kobayashi M,Honma S,Suzuki K

更新日期：2011-02-01 00:00:00

abstract：:There are currently two main candidates for the membrane receptor for 1,25(OH)2D3: the 1,25D3-MARRS protein/ERp57; and the classical VDR. The 1,25D3-MARRS protein is essential for hormone-stimulated phosphate and calcium uptake in chick intestinal cells, whereas the VDR is not. The 1,25D3-MARRS protein also shows a hi...

journal_title：Steroids

authors： Nemere I

更新日期：2005-05-01 00:00:00

abstract：:18,20-Epoxy-11 beta,17 alpha,20 beta,21-tetrahydroxypregn-4-en-3-one was synthesized by the application of hypoiodite reaction to the cortisol acetonide. The intermediary 18-iodo derivative was converted to the 11-oxo steroid by chromic acid prior to silver ion-assisted solvolysis. Removal of the protective group with...

journal_title：Steroids

authors： Kurosawa T,Ikegawa S,Chiba H,Ito Y,Nakagawa S,Kobayashi K,Tohma M

更新日期：1992-09-01 00:00:00

abstract：:A radio-gas chromatographic method has been devised for the estimation of 11-oxotestosterone (17beta-hydroxyandrost-4-ene-3, 11-dione) in fish plasma samples which provides an independent means of validating the radioimmunoassay described earlier. Estimates of the concentration of 11-oxotestosterone in a sample of mal...

journal_title：Steroids

authors： Simpson TH,Wright RS

更新日期：1978-05-01 00:00:00

abstract：:We describe the development of a serum chlormadinone acetate (CMA) time-resolved fluoroimmunoassay (TR-FIA). We prepared haptens (3-CMO-chlormadinone acetate and 6-chloropregna-4,6-dien-17,20-diol-3-one-20-hemisuccinate), biotinylated tracers (3(biotinylaminopropylamido) 3-CMO-chlormadinone acetate and 3-(6-chloropreg...

journal_title：Steroids

authors： Fiet J,Giton F,Auzerie J,Galons H

更新日期：2002-12-01 00:00:00

abstract：:The crystal structures of chenodeoxycholic acid (CDCA), ursodeoxycholic acid (7beta isomer of CDCA) and their other two epimers (3beta,7alpha- and 3beta,7beta-isomers) have been resolved. The four isomers were recrystallized from p-xylene. CDCA crystal is hexagonal P6(5) while the crystals of the other three isomers a...

journal_title：Steroids

authors： Alvarez M,Jover A,Carrazana J,Meijide F,Soto VH,Tato JV

更新日期：2007-06-01 00:00:00

abstract：:Bile acid conjugates are found in human breast cyst fluid in average concentrations about 50-fold greater than those in blood. Because epidemiologic studies have linked colon and breast cancer and aberrant bile acid profiles are associated with colon cancer risk, we decided to study the influence of bile acid conjugat...

journal_title：Steroids

authors： Raju U,Katz J,Levitz M

更新日期：1997-10-01 00:00:00

abstract：:The xenobiotic receptors CAR and PXR constitute two important members of the NR1I nuclear receptor family. They function as sensors of toxic byproducts derived from endogenous metabolism and of exogenous chemicals, in order to enhance their elimination. This unique function of CAR and PXR sets them apart from the ster...

journal_title：Steroids

authors： Timsit YE,Negishi M

更新日期：2007-03-01 00:00:00

abstract：:When day 6 rabbit blastocysts were cultured (3 embryos/mL) in medium 199 containing 3.68 microM estradiol-17 beta (E2), 40% of E2 was metabolized in 24 h, at a rate of 18 pmol/embryo(b)/h, yielding 4 major metabolite fractions. Two of them were identified to be estrogen glucosides: 17 beta-hydroxyestra-1,3,5(10)-trien...

journal_title：Steroids

authors： Wu JT,Williams KI

更新日期：1989-10-01 00:00:00

abstract：:This study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 T scanner and quantitative image analysis was established and employed to measure the individual muscl...

journal_title：Steroids

authors： Wu EX,Tang H,Tong C,Heymsfield SB,Vasselli JR

更新日期：2008-04-01 00:00:00

abstract：:Spermatozoa from bovine ejaculates and cauda epiditymidis were incubated with either tritiated 17 beta-hydroxy-5 alpha-androstane-3-one (DHT) or 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol). Examination of the medium incubations demonstrated metabolic conversion of both DHT and 3 alpha-diol when these steri...

journal_title：Steroids

authors： Djöseland O,Høglo S,Nyberg K,Hastings CD,Attramadal A

更新日期：1978-03-01 00:00:00

abstract：:Synthetic transformations of steroids for drug discovery and improvement of drug effectiveness have been an important part of modern medicinal chemistry and pharmaceutical sciences. Pentacyclic triterpenoids, being represented in the nature by various structures and biogenetically related to steroids, can largely expa...

journal_title：Steroids

authors： Tolmacheva IA,Nazarov AV,Eroshenko DV,Grishko VV

更新日期：2018-12-01 00:00:00

abstract：:3beta-Hydroxy sterols occurring at a concentration of at least 0.001% of the sterol mixtures of Pseudoplexaura porosa and Plexaura homomalla have been fractionated using a series of refined techniques and subsequently analyzed using combined gas chromatography-mass spectrometry (GC-MS) in the development of a procedur...

journal_title：Steroids

authors： Popov S,Carlson RM,Wegmann A,Djerassi C

更新日期：1976-11-01 00:00:00

abstract：:A radioimmunoassay for plasma 3 beta, 7 alpha-dihydroxy-5-androsten-17-one (7 alpha-hydroxy DHA) has been developed using anti-sera raised against 3 beta, 7 alpha-dihydroxy-5-androstene-17 beta-carboxyl-bovine serum albumin conjugate and [1, 2 (n) - 3H] 7 alpha-hydroxy DHA as the radioligand. Significant cross reactiv...

journal_title：Steroids

authors： Skinner SJ,Tobler CJ,Couch RA

更新日期：1977-09-01 00:00:00

abstract：:The receptor profiles and in vivo activity of tibolone, and its primary metabolites, Delta(4)-isomer, and 3alpha- and 3beta-hydroxytibolone, were studied and compared to those of structurally related compounds. The Delta(4)-isomer was the strongest binder and activator of the progesterone receptor (PR); tibolone was 1...

journal_title：Steroids

authors： de Gooyer ME,Deckers GH,Schoonen WG,Verheul HA,Kloosterboer HJ

更新日期：2003-01-01 00:00:00

abstract：:The mass spectral elimination of water in epimeric 1,3-diols of vitamin D3 (colecalciferol) series has been investigated. It was found that the mass spectra of these steroisomers differ sharply in the relative intensities of the ions M-H2O (m/e 382) and a-H2O (m/e +/- 34), where ion a (formed via formal cleavage of th...

journal_title：Steroids

authors： Zaretskii ZV

更新日期：1979-05-01 00:00:00

abstract：:Given the close resemblance of the ring A structure of prednisolone and prednisone on the one hand, and of androstadienedione on the other, the transformation of cortisol and cortisone into prednisolone and prednisone in cattle faeces was evaluated. A simple method that does not involve extraction but only the 1:100 d...

journal_title：Steroids

authors： Arioli F,Fidani M,Casati A,Fracchiolla ML,Pompa G

更新日期：2010-04-01 00:00:00

abstract：:Male rabbits were infused at a constant rate with 3H-androstenedione/14C-estrone (n = 5) or 3H-testosterone/14C-estradiol-17 beta (n = 3) for 3 1/2 hr and blood samples were obtained over the last hour and analyzed for radioactivity as androstenedione (A), testosterone (T), estrone (E1), estradiol-17 beta (E2 beta) an...

journal_title：Steroids

authors： Bourget C,Flood C,Longcope C

更新日期：1984-02-01 00:00:00