Abstract:
:A phytochemical study of Physalis pubescens L. afforded twelve compounds, including six new withanolides (1, 4, and 6i-9), four new withanolide glucosides (2, 3, 5, and 6), and two known withanolides (10 and 11). Their structures were established via extensive spectroscopic analysis. The absolute configuration of 3 was assigned using X-ray crystallography, and the absolute configurations of the 1,2-diol moiety in 1 were determined using the in situ dimolybdenum electronic circular dichroism method. Compounds 7, 9, and 10 exhibited significant cytotoxicity against human prostate cancer cells (C4-2B and 22Rvl), human renal carcinoma cells (786-O, A-498, Caki-2, and ACHN), human melanoma cells (A375 and A375-S2), and human normal hepatic cell line (L02) with IC50 values in the range of 0.17-5.30μM.
journal_name
Steroidsjournal_title
Steroidsauthors
Xia G,Li Y,Sun J,Wang L,Tang X,Lin B,Kang N,Huang J,Chen L,Qiu Fdoi
10.1016/j.steroids.2016.09.002subject
Has Abstractpub_date
2016-11-01 00:00:00pages
136-146eissn
0039-128Xissn
1878-5867pii
S0039-128X(16)30117-9journal_volume
115pub_type
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