Abstract:
:A heretofore unknown metabolite of vitamin D3 was isolated from the 1 alpha, 24, 25-trihydroxyvitamin D3 fraction of lipid extracts obtained from plasma of rats which were given intravenous or oral doses of 100 pmol/100 g of either 1 alpha-hydroxyvitamin D3 or 1 alpha, 23-dihydroxyvitamin D3. Doses of 25-250 pmoles of the new metabolite when given to a vitamin D deficient rat were completely inactive in terms of stimulating the classic vitamin D response of bone calcium mobilization. The nature of the metabolism of 1 alpha-hydroxyvitamin D3 or 1 alpha, 25-dihydroxyvitamin D3 to the metabolite is not clear at the present time, but it is probable that neither of these steroids undergo side-chain cleavage to yield the new metabolite.
journal_name
Steroidsjournal_title
Steroidsauthors
Ohnuma N,Kiyoki M,Bannai K,Naruchi T,Hashimoto Y,Noguchi T,Norman AWdoi
10.1016/0039-128x(80)90065-3subject
Has Abstractpub_date
1980-07-01 00:00:00pages
27-39issue
1eissn
0039-128Xissn
1878-5867pii
0039-128X(80)90065-3journal_volume
36pub_type
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