Synthesis and antiproliferative activity of 17-[1',2',3']-selenadiazolylpregnenolone compounds.

abstract：:There is considerable evidence that although estradiol may trigger the preovulatory surge of gonadotropins, progesterone is required for its full magnitude and duration and that glucocorticoids bring about selective follicle-stimulating hormone release. The luteinizing hormone-releasing hormone (LHRH) neuron does not ...

journal_title：Steroids

authors： Mahesh VB,Brann DW

更新日期：1998-05-01 00:00:00

abstract：:A series of novel 5α, 8α-endoperoxide steroidal hybrid derivatives containing isatin or indole substituents on the C-17 side chain were synthesized and characterized. The preliminary anti-proliferative activity of the compounds against HepG2, MCF-7, HT-29 and HeLa cell lines were investigated. Compounds 7g and 7l disp...

journal_title：Steroids

authors： Li H,Wang H,Wang J,Lin Y,Ma Y,Bu M

更新日期：2020-01-01 00:00:00

abstract：:A heretofore unknown metabolite of vitamin D3 was isolated from the 1 alpha, 24, 25-trihydroxyvitamin D3 fraction of lipid extracts obtained from plasma of rats which were given intravenous or oral doses of 100 pmol/100 g of either 1 alpha-hydroxyvitamin D3 or 1 alpha, 23-dihydroxyvitamin D3. Doses of 25-250 pmoles of...

journal_title：Steroids

authors： Ohnuma N,Kiyoki M,Bannai K,Naruchi T,Hashimoto Y,Noguchi T,Norman AW

更新日期：1980-07-01 00:00:00

abstract：:A long-term metabolite of the doping agent oxymetholone (OXM-M2, 17β-hydroxymethyl-2,17α-methyl-18-norandrost-13-en-3-one) which has been identified by GC-MS/MS was synthesized from commercially available materials. Two efficient synthetic routes to access both C-17 epimers of tentative metabolites were developed. The...

journal_title：Steroids

authors： Kratena N,Biedermann N,Stojanovic B,Göschl L,Weil M,Enev VS,Gmeiner G,Gärtner P

更新日期：2019-10-01 00:00:00

abstract：:The effect of attachment of a dimethylaminoethoxy or a dimethylaminopropoxy group at the 11 beta-position of estradiol (E2) on its relative binding affinity (RBA) to estrogen receptor (ER) and intrinsic biologic activity is described. The binding of 11 beta-[2-(N,N-dimethylamino) ethoxy]estra-1,3,5(10)-triene-3,17 bet...

journal_title：Steroids

authors： Qian XD,Abul-Hajj YJ

更新日期：1990-05-01 00:00:00

abstract：:Ten new 9,11-secosteroids, subergorgols A-J (1-10), including two pairs of epimers (3/4, and 6/7), along with three known analogues (11-13) were isolated from the South China Sea gorgonian Subergorgia suberosa. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses and compa...

journal_title：Steroids

authors： Zhang G,Tang X,Cheng C,Gong K,Zhang X,Zhu H,Wu R,Li P,Li G

更新日期：2013-09-01 00:00:00

abstract：:Smith-Lemli-Opitz syndrome (SLOS) is a malformation syndrome associated with 7-dehydrocholesterol (7DHC) 7-reductase deficiency. Although SLOS can be detected in an affected fetus before midpregnancy by measurement of 7DHC levels in amniotic fluid or chorionic villus cells, a noninvasive, more routine method is needed...

journal_title：Steroids

authors： Shackleton CH,Roitman E,Kratz LE,Kelley RI

更新日期：1999-07-01 00:00:00

abstract：BACKGROUND:Congenital adrenal hyperplasia (CAH) caused by 21-hydroxylase deficiency (21OHD) is an autosomal recessive disorder due to mutation in the CYP21A2 gene. OBJECTIVE:To elucidate the genetic basis of 21-hydroxylase-deficient CAH in Hong Kong Chinese patients. PATIENTS AND METHODS:Mutational analysis of the CY...

journal_title：Steroids

authors： Chan AO,But WM,Ng KL,Wong LM,Lam YY,Tiu SC,Lee KF,Lee CY,Loung PY,Berry IR,Brown R,Charlton R,Cheng CW,Ho YC,Tse WY,Shek CC

更新日期：2011-09-01 00:00:00

abstract：:Using dehydroepiandrosterone as the starting material, we have synthesized a series of steroid analogs possessing a D-ring fused with heterocycles which are pyridine, imidazo [2,1-b]thiazoles or substituted thiazole imines. All the final structures are first reported and identified by NMR and MS spectroscopys, the yie...

journal_title：Steroids

authors： Zhang BL,Zhang E,Pang LP,Song LX,Li YF,Yu B,Liu HM

更新日期：2013-12-11 00:00:00

abstract：:Using cultured Y-1 mouse adrenal tumor cells which produce 20 alpha-hydroxy-4-pregnen-3-one (20-DHP), it was found that 0.01 mM corticosterone and deoxycorticosterone increased basal and inhibited ACTH-induced 20-DHP production during consecutive 30 and 120 min incubations. Steroid effects were concentration-dependent...

journal_title：Steroids

authors： Mattson MP,Mrotek JJ

更新日期：1985-07-01 00:00:00

abstract：:The role of an estrogen-binding protein similar to a known mammalian estrogen receptor (ER) is described in the estradiol-dependent reproduction of the helminth parasite Taenia crassiceps. Previous results have shown that 17-β-estradiol induces a concentration-dependent increase in bud number of in vitro cultured cyst...

journal_title：Steroids

authors： Ibarra-Coronado EG,Escobedo G,Nava-Castro K,Jesús Ramses CR,Hernández-Bello R,García-Varela M,Ambrosio JR,Reynoso-Ducoing O,Fonseca-Liñán R,Ortega-Pierres G,Pavón L,Hernández ME,Morales-Montor J

更新日期：2011-09-01 00:00:00

abstract：:By the conventional methods of gas liquid chromatography (GLC) as well as mass spectrometry, 3beta,7alpha-dihydroxychol-5-en-24-oic acid (delta5-acid), a key intermediate of chenodeoxycholic acid biogenesis and its metabolic by-product, 3alpha,7alpha-dihydroxychol-4-en-24-oic acid (delta4-acid) have not yet been ident...

journal_title：Steroids

authors： Ikeda M,Yamasaki K

更新日期：1978-07-01 00:00:00

abstract：:Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cell...

journal_title：Steroids

authors： Walker WH

更新日期：2009-07-01 00:00:00

abstract：:A radioimmunoassay for the quantitation of the sum of free, glucuronidated and urine is described. The method is reliable and accurate. Using this method, urinary excretion of 16 alpha-hydroxyestrone was determined in normal men, premenopausal women, and postmenopausal women. The values were compared to the urinary ex...

journal_title：Steroids

authors： Naganuma H,Hershcopf RJ,Michnovicz JJ,Miyairi S,Bradlow HL,Fishman J

更新日期：1989-01-01 00:00:00

abstract：:The four diastereomeric 3,16-diacetates 6, 9, 10 and 11 were prepared from gitoxin 1 by the routes shown in Schemes 1 and 2 and tested for inotropic activity in the isolated guinea-pig atrial preparation. In line with earlier findings in the digitoxigenin series, derivatives with a 3 alpha-acetoxy function, viz 9 and ...

journal_title：Steroids

authors： Humber DC,Jones PS,Phillipps GH

更新日期：1985-01-01 00:00:00

abstract：:This paper revealed the expression pattern of ERα in the ovoviviparous teleost, Sebastes schlegeli. In this paper, we isolated the cDNA encoding for estrogen receptor alpha of black rockfish (S. schlegeli) from its ovary, named as black rockfish ERα (brfERα). The cDNA sequence of brfERα consists of 2972bp with an open...

journal_title：Steroids

authors： Shi D,Wen HS,He F,Li JF,Yang YP,Chen CF,Zhang JR,Chen XY,Jin GX,Shi B,Qi BX,Li N

更新日期：2011-12-20 00:00:00

abstract：:The present study was undertaken to examine the mechanism whereby beta-lipotropin stimulates adrenal steroidogenesis. In guinea pig adrenal cells, beta-lipotropin (10(-8) M) increased basal steroid production 6-, 4-, and 5-fold for cortisol, androstenedione, and dehydroepiandrosterone (DHEA), respectively, whereas the...

journal_title：Steroids

authors： O'Connell Y,McKenna TJ,Cunningham SK

更新日期：1996-05-01 00:00:00

abstract：:This study represents a continuing effort to find a new biomarker for the diagnosis and management of prostatic cancer. Polyclonal antibodies were prepared to a peptide (CAKP) representing amino acids 28 to 43 of the 5 alpha-reductase type 2 isozyme. Using immunoaffinity-purified antibodies, the sera of 62 patients we...

journal_title：Steroids

authors： Lombardo ME,Hudson PB

更新日期：1996-11-01 00:00:00

abstract：:In this study, effects of estradiol, progesterone and genistein on uterine aquaporin (AQP)-1, 2, 5 and 7 expression were investigated in sex-steroid deficient state which could help to elucidate the mechanisms underlying uterine fluid volume changes that were reported under these hormone and hormone-like compound infl...

journal_title：Steroids

authors： Chinigarzadeh A,Muniandy S,Salleh N

更新日期：2016-11-01 00:00:00

abstract：:Variations in sex steroids bioavailability were linked to the gender difference in the growth of thyroid glands of neonatal rats. In the present study we tested androgen receptor (AR) and estrogen receptor (ER) concentrations by ligand binding assay, and expression of their genes by RT-PCR and Western blot in the thyr...

journal_title：Steroids

authors： Stanley JA,Aruldhas MM,Yuvaraju PB,Banu SK,Anbalagan J,Neelamohan R,Annapoorna K,Jayaraman G

更新日期：2010-12-12 00:00:00

abstract：BACKGROUND:Estrogen replacement therapy increases risk for ovarian epithelial cancer, a cancer of mainly older women, yet the response of older ovarian surface epithelium (OSE) to repeat estrogen exposure overtime has not been studied. We have previously reported significant reductions in estrogen receptor (ER) protein...

journal_title：Steroids

authors： Gulliver LS,Hurst PR

更新日期：2012-05-01 00:00:00

abstract：:Orally administered testosterone undecanoate (TU), an anabolic, androgenic steroid, can potentially be abused by athletes. Indirect evidence for detecting oral TU intake could be deduced from the changes in steroid profile post-administration. Direct evidence could be obtained by detection of unchanged TU in plasma. T...

journal_title：Steroids

authors： Peng SH,Segura J,Farré M,González JC,de la Torre X

更新日期：2002-01-01 00:00:00

abstract：:Gene therapy based on gene delivery is a promising strategy for the treatment of various human diseases such as cancer. Cationic lipids represent one of the important synthetic gene delivery systems. There is a great interest in imaging of gene therapy using the biomedical imaging technique positron emission tomograph...

journal_title：Steroids

authors： Gao M,Wang M,Miller KD,Sledge GW,Hutchins GD,Zheng QH

更新日期：2010-10-01 00:00:00

abstract：:Contrary to the long-held postulate of steroid-hormone binding globulin action, these protein carriers of steroids are major players in steroid actions in the body. This manuscript will focus on our work with sex hormone binding globulin (SHBG) and corticosteroid binding globulin (CBG) and demonstrate how they are act...

journal_title：Steroids

authors： Caldwell JD,Jirikowski GF

更新日期：2014-03-01 00:00:00

abstract：:Breast cancer risk is strongly related to several reproductive and hormonal factors, but the nature of the effects of endogenous oestrogens has been difficult to establish. Data are now available from several large prospective studies with biobanks of stored serum, enabling better characterization of the associations ...

journal_title：Steroids

authors： Key TJ

更新日期：2011-07-01 00:00:00

abstract：:2,2,6,6-Tetramethyl piperidine-N-oxyl nitroxyls are known to partition between aqueous and lipid phases, thus serving as probes to study membrane dynamics. The synthesis of a novel steroidal spin label, 3alpha-hydroxycholan-24-yl-(2",2",6",6"-tetramethyl-N-oxyl)p iperidyl butan-1',4'-dioate, containing 2,2,6,6-tetrame...

journal_title：Steroids

authors： Katoch R,Trivedi GK,Phadke RS

更新日期：1999-12-01 00:00:00

abstract：:Aldosterone induces fibrotic changes in cardiovascular tissues but its effects have usually been demonstrated in models of pre-existing renal injury and/or hypertension. This study tests the hypothesis that aldosterone can directly induce vascular fibrotic changes in the absence of prior renal injury or hypertension. ...

journal_title：Steroids

authors： Brem AS,Morris DJ,Li X,Ge Y,Shaw S,Gong R

更新日期：2013-03-01 00:00:00

abstract：:The mechanism accounting for the development of castration-resistant prostate cancer (CRPC) remains unclear. Studies in CRPC tissues suggest that, after androgen deprivation therapy (ADT), the adrenal androgens may be an important source of testosterone (T) and 5-alpha dihydrotestosterone (DHT) in CRPC tissues. To cla...

journal_title：Steroids

authors： Arai S,Miyashiro Y,Shibata Y,Tomaru Y,Kobayashi M,Honma S,Suzuki K

更新日期：2011-02-01 00:00:00

abstract：:The ALVA-41 cell line was derived from a bony metastasis from a human prostatic carcinoma. The line has a number of distinct, advantageous properties that should make it useful as a tool for the study of prostate cancer. It grows rapidly and is easy to work with. It has receptors for androgens and glucocorticoids but ...

journal_title：Steroids

authors： Nakhla AM,Rosner W

更新日期：1994-10-01 00:00:00

abstract：:To reduce the variability in estradiol (E2) testing and to assure better patient care, standardization of E2 measurements has been recommended. This study aims to assess the accuracy and variability of E2 measurements performed by 11 routine immunological methods and 6 mass spectrometry methods using single donor seru...

journal_title：Steroids

authors： Vesper HW,Botelho JC,Vidal ML,Rahmani Y,Thienpont LM,Caudill SP

更新日期：2014-04-01 00:00:00