Synthesis of novel 16-spiro steroids: spiro-7'-(aryl)tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazolo-trans-androsterone hybrid heterocycles.

abstract：:Progestagens inhibit growth of endometrial cancer cells in vivo and in vitro, and also are reported to inhibit endometrial cancer cell invasion. The progesterone receptor (PR) isotypes PRA and PRB have different transcriptional activity. There are indications that relative over expression of PRB could lead to developm...

journal_title：Steroids

authors： Hanekamp EE,Gielen SC,van Oosterhoud SA,Burger CW,Grootegoed JA,Huikeshoven FJ,Blok LJ

更新日期：2003-11-01 00:00:00

abstract：:Counterfeiting and adulteration of pharmaceuticals is a prevalent problem worldwide and represents a major health risk to the population, with anabolic steroids being one of the main classes of drugs consumed and obtained from dubious sources. In this work, we propose the use of the 1H NMR technique to evaluate formul...

journal_title：Steroids

authors： Ribeiro MVM,Boralle N,Felippe LG,Pezza HR,Pezza L

更新日期：2018-10-01 00:00:00

abstract：:The concentration of estrogens in the body fluids of women is highly variable, due to the menstrual cycle, circadian oscillations, and other physiological and pathological causes. To date, only the cyclic fluctuations of the principal estrogens (estradiol and estrone) have been studied, with limited outcome of general...

journal_title：Steroids

authors： Bozzolino C,Vaglio S,Amante E,Alladio E,Gerace E,Salomone A,Vincenti M

更新日期：2019-10-01 00:00:00

abstract：:A technique of incubation of testicular tissue in vitro with radiolabeled precursors was applied in the investigation of the steroid biosynthesis by testes of four young men after long-term, high-dose estrogen treatment. A positive correlation between plasma and testicular steroid levels, and in vitro capacity of the ...

journal_title：Steroids

authors： Rodriguez-Rigau LJ,Tcholakian RK,Smith KD,Steinberger E

更新日期：1977-06-01 00:00:00

abstract：:In an attempt to synthesize compounds with selective estrogen-receptor binding, fluoro- and amino-clomiphene were totally synthesized from benzyl chloride, and their estrogenic/antiestrogenic activity as well as that of some of their chemical intermediates was evaluated. The triazene prepared from the amino-clomiphene...

journal_title：Steroids

authors： Gazit A,Livshitz T,Shani J

更新日期：1986-07-01 00:00:00

abstract：:Hydroxycitric acid (HCA), a dietary-derived weight loss supplement, competitively inhibits ATP citrate lyase (ACLY). Tamoxifen (TAM) is the most frequently used therapy for estrogen receptor (ER)-positive breast cancer patients, but its application was restricted due to efficacy related issues. Lipid metabolic reprogr...

journal_title：Steroids

authors： Ismail A,Doghish AS,E M Elsadek B,Salama SA,Mariee AD

更新日期：2020-08-01 00:00:00

abstract：:Spermatozoa from bovine ejaculates and cauda epiditymidis were incubated with either tritiated 17 beta-hydroxy-5 alpha-androstane-3-one (DHT) or 5 alpha-androstane-3 alpha, 17 beta-diol (3 alpha-diol). Examination of the medium incubations demonstrated metabolic conversion of both DHT and 3 alpha-diol when these steri...

journal_title：Steroids

authors： Djöseland O,Høglo S,Nyberg K,Hastings CD,Attramadal A

更新日期：1978-03-01 00:00:00

abstract：:During the second half of the luteal phase, the human corpus luteum becomes responsive to regular luteinizing hormone (LH) pulses. These LH pulses stimulate progesterone secretion tonically, and during this tonic stimulation, additional LH-independent progesterone pulses occur, which are particularly pronounced in wom...

journal_title：Steroids

authors： Wuttke W,Theiling K,Hinney B,Pitzel L

更新日期：1998-05-01 00:00:00

abstract：:The effect of steroids contained in oral contraceptives, namely ethinylestradiol:17 alpha-ethinyl-1,3,5,(10)-estratriene-3, 17-diol (E) and norethindrone acetate:17 beta-acetoxy-17-ethinyl-4-estren-3-one (N), on cell replication and human chorionic gonadotropin (hCG) secretion by choriocarcinoma cells in monolayer cul...

journal_title：Steroids

authors： Gal D,Simpson ER,Porter JC,MacDonald PC,Buchsbaum HJ

更新日期：1981-06-01 00:00:00

abstract：:A number of progesterone derivatives, having a 17 alpha-acetoxy group and various functions at C-3 and C-6, interact at the cardiac glycoside (CG) binding site, using [3H]ouabain in a radioligand binding assay (RBA) with membranes from dog myocardium. We now report on results of structure-activity studies concerned wi...

journal_title：Steroids

authors： Templeton JF,Kumar VP,Kim RS,LaBella FS

更新日期：1987-04-01 00:00:00

abstract：:Human placental estradiol 17 beta-dehydrogenase (E.C. 1.1.1.62) was inactivated at pH 6.3 by 3-bromo [2'-14C] acetoxy-1,3,5(10) estratrien-17-one, a know substrate. The affinity-alkylated enzyme was then hydrolyzed by trypsin. Radioactive peptides were initially isolated by gel filtration and identified according to w...

journal_title：Steroids

authors： Murdock GL,Warren JC

更新日期：1982-02-01 00:00:00

abstract：:Steroids have been shown to have multiple effects on the nervous system including neuroprotective activities, and they have the potential to be used for the treatment of neurodegenerative diseases. In this current study, we tested the hypothesis that the marine steroid 24-methylenecholestane-3β,5α,6β,19-tetraol (Tetro...

journal_title：Steroids

authors： Leng T,Liu A,Wang Y,Chen X,Zhou S,Li Q,Zhu W,Zhou Y,Su X,Huang Y,Yin W,Qiu P,Hu H,Xiong ZG,Zhang J,Yan G

更新日期：2016-01-01 00:00:00

abstract：:It is well established that 1alpha,25-dihydroxyvitamin D(3) (1alpha,25(OH)(2)D(3)), the active metabolite of vitamin D, plays a role in regulating proliferation and differentiation of cells, in addition to its classic function in mineral homeostasis. Recent studies have also provided evidence for the involvement of 1a...

journal_title：Steroids

authors： Shany S,Levy Y,Lahav-Cohen M

更新日期：2001-03-01 00:00:00

abstract：:A radioimmunoassay technique has been developed for the measurement of cortisol in a single methylene chloride extract of human plasma without chromatography. The antiserum, obtained by immunizing rabbits with cortisol-3-carboxymethyl-oxime conjugated to bovine serum albumin, had a high affinity (KA = 1.8 X 10(9) 1/mo...

journal_title：Steroids

authors： Dash RJ,England BG,Midgley AR Jr,Niswender GD

更新日期：1975-11-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown. Here, we focus on the effect of DHEA on the activation of endothelial cells induced by a high concentration of glucose. Adhesion on U937 cells, expression of adhesion molecules, pro...

journal_title：Steroids

authors： Huerta-García E,Ventura-Gallegos JL,Victoriano ME,Montiél-Dávalos A,Tinoco-Jaramillo G,López-Marure R

更新日期：2012-02-01 00:00:00

abstract：:The catalytic cycloalumination of 2'-methylidene-2',3'-ethano-(5α)-cholestane with Et3Al catalyzed by Cp2ZrCl2 was performed for the first time to give spiro[2',3'-ethano-(5α)-cholestane-2',3″-aluminacyclopentane] in a ~75% yield and with high stereoselectivity (>98%). The obtained cyclic organoaluminum compound was t...

journal_title：Steroids

authors： D'yakonov VA,Tuktarova RA,Islamov II,Khalilov LM,Dzhemilev UM

更新日期：2013-12-11 00:00:00

abstract：:Human progesterone receptor (PR) contains a polyproline motif in the amino-terminal domain that interacts with the SH3 domain of Src and mediates rapid activation of c-Src and downstream MAPK (Erk-1/-2) independent of the transcriptional activity of PR. Forcedly target PR to different locations in the cell by use of m...

journal_title：Steroids

authors： Boonyaratanakornkit V,Bi Y,Rudd M,Edwards DP

更新日期：2008-10-01 00:00:00

abstract：:The role of an estrogen-binding protein similar to a known mammalian estrogen receptor (ER) is described in the estradiol-dependent reproduction of the helminth parasite Taenia crassiceps. Previous results have shown that 17-β-estradiol induces a concentration-dependent increase in bud number of in vitro cultured cyst...

journal_title：Steroids

authors： Ibarra-Coronado EG,Escobedo G,Nava-Castro K,Jesús Ramses CR,Hernández-Bello R,García-Varela M,Ambrosio JR,Reynoso-Ducoing O,Fonseca-Liñán R,Ortega-Pierres G,Pavón L,Hernández ME,Morales-Montor J

更新日期：2011-09-01 00:00:00

abstract：:This study was designed to describe the time-course changes of catabolic proteins following muscle atrophy induced by 10 days of dexamethasone (DEX). Rats underwent DEX treatment for 1, 3, 5, 7 and 10 days. Body weight (BW) and lean mass were obtained using a dual energy X-ray absorptiometry (DEXA) scan. Muscle ringer...

journal_title：Steroids

authors： Macedo AG,Krug AL,Souza LM,Martuscelli AM,Constantino PB,Zago AS,Rush JW,Santos CF,Amaral SL

更新日期：2016-03-01 00:00:00

abstract：:The sterol mixture isolated from the marine alga Eutreptia viridis consists mainly of delta 5,7-dienes which account for 80% of the free sterols. Eighteen different sterols were detected, including a novel sterol with the rare delta 23-unsaturation, viz. 24-ethylcholesta-5,7,23Z-trien-3 beta-o1. ...

journal_title：Steroids

authors： Zielinski J,Kokke WC,Fenical W,Djerassi C

更新日期：1982-10-01 00:00:00

abstract：:Six naturally occurring C27 ecdysteroids were isolated and identified from the tobacco hornworm during pupal-adult development five days after peak titer of molting hormone activity. In order of decreasing quantities the hormones were: 20,26-dihydroxyecdysone, 3-epi-20-hydroxyecdysone, 20hydroxyecdysone, 3-epi-20,26-d...

journal_title：Steroids

authors： Kaplanis JN,Thompson MJ,Dutky SR,Robbins WE

更新日期：1979-09-01 00:00:00

abstract：:Traditional interpretation of GC-MS output involved the semi-quantitative estimation of outstanding low or high specific metabolites and the ratio between metabolites. Here, we utilize a systems biology approach to steroid metabolomics of a complex steroid-related disorder, using an all-inclusive analysis of the stero...

journal_title：Steroids

authors： Vitkin E,Ben-Dor A,Shmoish M,Hartmann MF,Yakhini Z,Wudy SA,Hochberg Z

更新日期：2014-10-01 00:00:00

abstract：:Enzyme immunoassays (EIA) are commonly utilized for the evaluation of androgens in biological fluids; however, careful consideration must be given to cross-reactivity with other endogenous sex-steroid hormones. Our purpose was to determine the validity of a commonly-utilized commercially-available dihydrotestosterone ...

journal_title：Steroids

authors： Yarrow JF,Beck DT,Conover CF,Beggs LA,Goldberger BA,Borst SE

更新日期：2013-12-11 00:00:00

abstract：:A phytochemical study of Physalis pubescens L. afforded twelve compounds, including six new withanolides (1, 4, and 6i-9), four new withanolide glucosides (2, 3, 5, and 6), and two known withanolides (10 and 11). Their structures were established via extensive spectroscopic analysis. The absolute configuration of 3 wa...

journal_title：Steroids

authors： Xia G,Li Y,Sun J,Wang L,Tang X,Lin B,Kang N,Huang J,Chen L,Qiu F

更新日期：2016-11-01 00:00:00

abstract：:A series of final twelve propanoyloxy derivatives of 5β-cholan-24-oic acid (O-propanoyl derivatives of cholic acid) as potential drug absorption modifiers (skin penetration enhancers, intestinal absorption promoters) was generated by multistep synthesis. Structure confirmation of all generated compounds was accomplish...

journal_title：Steroids

authors： Coufalová L,Mrózek L,Rárová L,Plaček L,Opatřilová R,Dohnal J,Král'ová K,Paleta O,Král V,Drašar P,Jampílek J

更新日期：2013-05-01 00:00:00

abstract：:The palladium-catalyzed coupling of various 17-iodo-delta 16 steroids (17-iodo-androst-16-ene, 17-iodo-4-methyl-4-aza-androst-16-en-3-one, and 17-iodo-4-aza-androst-16-en-3-one) with dialkyl phosphites (dimethyl phosphite, diethyl phosphite, and diisopropyl phosphite) was examined in detail. The only successful condit...

journal_title：Steroids

authors： Skoda-Földes R,Kollár L,Horváth J,Tuba Z

更新日期：1995-12-01 00:00:00

abstract：:1,25-Dihydroxyvitamin D(3) (1,25D) regulates gene transcription through a nuclear vitamin D receptor (VDR) which acts as a ligand-regulated transcription factor. Some structural vitamin D analogs (VDAs) are selective in their biological actions, because they retain cell-differentiating potential, while their calcemic ...

journal_title：Steroids

authors： Gocek E,Kiełbiński M,Wyłób P,Kutner A,Marcinkowska E

更新日期：2008-12-22 00:00:00

abstract：:The structure of dehydro-oogoniol (3 beta,11 alpha,15 beta,29-tetrahydroxystigmasta-5,24(28)(E)-dien-7-one), a female-activating hormone of the water mold Achlya, has been confirmed by synthesis. The starting material was progesterone, which was converted to the 11 alpha, 15 beta-dihydroxy derivative by microbiologica...

journal_title：Steroids

authors： McMorris TC,Le PH,Preus MW,Schow SR,Weihe GR

更新日期：1989-03-01 00:00:00

abstract：:Dehydroepiandrosterone (DHEA) fatty acyl esters once incorporated in high density lipoprotein (HDL) induce a stronger vasodilatory response in rat mesenteric arteries ex vivo compared to native HDL. We studied the role of HDL receptor, scavenger receptor class B, type 1 (SR-B1), as well as estrogen and androgen recept...

journal_title：Steroids

authors： Paatela H,Vihma V,Jauhiainen M,Mervaala E,Tikkanen MJ

更新日期：2011-03-01 00:00:00

abstract：:Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium(II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. Coordination via the thionic sulfur and the azomethine nitrogen atom of the thiosemicarbazone to the Ru(II) metal. Steroidal thiosemicarbazone derivatives were obtained...

journal_title：Steroids

authors： Khan SA,Asiri AM

更新日期：2017-08-01 00:00:00