Abstract：
:The concentration of testosterone (T) in the peripheral plasma of laboratory mice is extremely variable. This variability is already evident at 20--25 days of age and is not eliminated by brief or chronic exposure to male or female mice, or by isolation. The variation in T levels in plasma samples collected from the same animals on different occasions is comparable to the variation between individuals bled on a single occasion. The concentration of T in the testis is as variable as that in the peripheral plasma. It is suggested that in the laboratory mouse T is produced and released in an episodic fashion, that elevations in T levels in peripheral plasma of mice are greater than those observed in other species, and that testicular secretory episodes are interspersed with periods of minimal steroidogenic activity.
journal_name
Steroidsjournal_title
Steroidsauthors
Bartke A,Dalterio Sdoi
10.1016/0039-128x(75)90107-5subject
Has Abstractpub_date
1975-12-01 00:00:00pages
749-56issue
6eissn
0039-128Xissn
1878-5867pii
0039-128X(75)90107-5journal_volume
26pub_type
杂志文章相关文献
STEROIDS文献大全abstract：:The determination of the glucurono-conjugated position in three bile alcohol glucuronides secreted in bile of a patient with cerebrotendinous xanthomatosis was carried out by a nuclear magnetic resonance study. The bile sample was extracted with ethanol and chromatographed on an ion-exchange column, a reverse-phase pa...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(95)00095-8
更新日期：1995-10-01 00:00:00
abstract：:We synthesized 22-fluorovitamin D3 from (22S) cholest-5-ene-3 beta, 22-diol-3 beta-acetate 2. Compound 2 was treated with diethylaminosulfur trifluoride to give 22-fluorocholest-5-en-3 beta-acetate 3 and (E) 22-dehydrocholest-5-en-3 beta-acetate. Compound 3 was treated with N-bromosuccinimide to give a mixture of the ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(86)90044-9
更新日期：1986-07-01 00:00:00
abstract：:26,26,26,27,27,27-Hexafluo-1,25(OH)2 vitamin D3, the hexafluorinated analog of 1,25(OH)2 vitamin D3, has been reported to be several times more potent than the parent compound regarding some vitamin D actions. The reason for enhanced biologic activity in the kidneys and small intestine appears to be related to F6-1,25...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(98)00055-5
更新日期：1998-10-01 00:00:00
abstract：:Synthesis of 3 beta,17 beta-dihydroxy-7 alpha/7 beta-(4-hydroxyphenyl)-androst-5-ene 3,17-diacetate (4 and 5, R = H) and 3 beta,17 beta-dihydroxy-7 alpha/7 beta-(4-methoxyphenyl)-androst-5-ene 3,17-diacetate (4 and 5, R = Me) have been carried out by Friedel-Crafts reaction on 3 beta,7,17 beta-trihydroxy-androst-5-ene...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(95)00007-d
更新日期：1995-06-01 00:00:00
abstract：:The hepatic metabolism of 3-oxoandrost-4-ene-17 beta-carboxylic acid (etienic acid), a probable acidic catabolite of deoxycorticosterone, was investigated using rats prepared with an external biliary fistula. Metabolic products were identified by GC-MS after hydrolysis with beta-glucuronidase and by proton nuclear mag...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(92)90052-b
更新日期：1992-07-01 00:00:00
abstract：:Cortisol 21-amine (21-amino-11beta,17-dihydroxy-4-pregnene-3,20-dione) was prepared and an enzyme immunoassay for cortisol in serum was established using cortisol 21-amine conjugated with alkaline phosphatase. The minimal amount of cortisol detected was 1ng/tube and the measurable range was from 1 to 80 microgram/d1, ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(78)90106-x
更新日期：1978-07-01 00:00:00
abstract：:18,20-Epoxy-11 beta,17 alpha,20 beta,21-tetrahydroxypregn-4-en-3-one was synthesized by the application of hypoiodite reaction to the cortisol acetonide. The intermediary 18-iodo derivative was converted to the 11-oxo steroid by chromic acid prior to silver ion-assisted solvolysis. Removal of the protective group with...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(92)90095-q
更新日期：1992-09-01 00:00:00
abstract：:This study examined the role of protein kinase C enzymatic activity as a physiologic determinant of stromal cell death in decidua basalis (DB) during pregnancy. The expression of epidermal growth factor receptor (EGF-R) and Bcl2 was used as an indicator of stromal cell proliferation/survival, whereas Bax and the occur...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(99)00044-6
更新日期：1999-09-01 00:00:00
abstract：:The addition of molybdate to rabbit liver cytosol increased significantly the affinity of the glucocorticoid receptor for [3H] dexamethasone without influencing the concentration of binding sites. This effect was concentration dependent. Analysis of the binding data by curve-fitting and Scatchard plot revealed the occ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(84)90088-6
更新日期：1984-08-01 00:00:00
abstract：:Preimplantation rabbit embryos were incubated with pregnenolone and dehydroisoandrosterone under conditions which gave formazan precipitation by the histochemical technique. The metabolic fate of the labeled steroids was assessed simultaneously. There was no concomitant transformation of pregnenolone to progesterone a...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(81)80012-8
更新日期：1981-02-01 00:00:00
abstract：:These studies investigated whether treatment with carbenoxolone (CBX), an inhibitor of 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD), resulted in an enhanced mineralocorticoid response to endogenous or infused cortisol. In conscious sodium replete sheep with a parotid fistula, infusion of CBX (40 mg/h for 10 days...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(97)00141-4
更新日期：1998-02-01 00:00:00
abstract：:Many flavonoids and isoflavonoids have anti-diabetic effects in animal models. However, the mechanisms that are involved are generally unclear. Since 11β-hydroxysteroid dehydrogenases (HSD11Bs) play important roles in diabetes, we hypothesize that flavonoids and isoflavonoids may affect diabetes by targeting two isofo...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2018.01.013
更新日期：2018-04-01 00:00:00
abstract：:Tibolone is a highly effective postmenopausal hormone treatment that has its biological activity dependent on metabolism to 3alpha- and 3beta-OH tibolone, which bind solely to the estrogen receptor. Despite the high levels of estrogen receptor-binding metabolites in the circulation, the endometrium becomes atrophic, s...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2005.04.010
更新日期：2005-11-01 00:00:00
abstract：:Some intermediates in the cholesterol biosynthesis between lanosterol and cholesterol are capable of inducing resumption of meiosis in cultured mouse oocytes without the presence of gonadotropins. The mechanism by which these so-called Meiosis Activating Sterols (MAS) activate the meiotic process is unknown, and it is...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(02)00041-7
更新日期：2002-11-01 00:00:00
abstract：:Using cultured Y-1 mouse adrenal tumor cells which produce 20 alpha-hydroxy-4-pregnen-3-one (20-DHP), it was found that 0.01 mM corticosterone and deoxycorticosterone increased basal and inhibited ACTH-induced 20-DHP production during consecutive 30 and 120 min incubations. Steroid effects were concentration-dependent...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(85)90026-1
更新日期：1985-07-01 00:00:00
abstract：:Dehydroepiandrosterone (DHEA) supplementation has been anecdotally considered as a tool to improve body composition and health status. We aimed to verify the impact of DHEA supplementation on traditional measurements of body composition and blood pressure (BP) due to their clinical applicability. A meta-analysis of ra...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2020.108710
更新日期：2020-11-01 00:00:00
abstract：:(25S)-3-Oxocholesta-1,4-dien-26-oic acid (1) and a new (25S)-18-acetoxy-3-oxocholesta-1,4-dien-26-oic acid (2) were isolated from a soft coral Minabea sp. (cf. aldersladei) collected in North Sulawesi, Indonesia, together with two known cholic-acid-type compounds, 3-oxochol-1,4-dien-24-oic acid (3) and 3-oxochol-4-en-...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2009.04.002
更新日期：2009-09-01 00:00:00
abstract：:The accurate analysis of trace components in complex biological matrices requires the use of reliable internal standards. For liquid chromatography/mass spectrometry analysis, the stable isotope-labeled analogues of the analyte molecules are the most appropriate internal standards. In this paper the synthesis of the 3...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.08.007
更新日期：2012-11-01 00:00:00
abstract：:Contraceptive methods for breastfeeding women should be safe for the mother and infant and should not interfere with lactation. Progestin-only methods meet these conditions and can be used from the sixth week postpartum. Because all progestins are excreted in milk, those that are insufficiently active by the oral rout...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(00)00125-2
更新日期：2000-10-01 00:00:00
abstract：:Initial excretion studies with orally administered [monoethyl-1-3H] DES demonstrated the feces to be the principal mode of elimination of DES in the C3H mouse. Metabolic studies with tritiated DES and/or [UL-14C] DES were performed with orally dosed C3H high (MTV+) and low (MTV-) titer MMTV female mice. Extraction and...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(78)90029-6
更新日期：1978-04-01 00:00:00
abstract：:The ability of human adult adrenal to utilize progesterone (P4) for cortisol (F) synthesis in vitro has been compared with that of fetal adrenal tissue. Explant cultures were studied for 6 days using Ham's F10 medium supplemented with 10% fetal bovine serum (FBS), with or without added P4 as substrate. Short-term (4h)...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(86)90097-8
更新日期：1986-04-01 00:00:00
abstract：:Three new pregnane steroids, 2beta,3beta,5beta-trihydroxy-pregn-20-en-6-one (1), 3beta-hydroxy-5alpha-pregn-7,20-dien-6-one (2), and 3beta-acetoxy-5alpha-pregn-7,20-dien-6-one (3) were isolated from the twigs and leaves of Turraea pubescens, and were structurally elucidated on the basis of spectroscopic data and chemi...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2006.04.010
更新日期：2006-08-01 00:00:00
abstract：:The Na-K-2Cl cotransporter (NKCC2) regulates sodium transport along the thick ascending limb of Henle's loop and is important in control of sodium balance, renal concentrating ability and renin release. To determine if there are sex differences in NKCC2 abundance and/or distribution, and to evaluate the contribution o...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2010.05.014
更新日期：2010-11-01 00:00:00
abstract：:Osteoblasts are a main target for the steroid 1alpha,25(OH)2-Vitamin D3 (1,25D3), where a major outcome is the modulation of the bone remodeling process. 1,25D3 deficiency leads to clinical disorders such as osteomalacia and osteoporosis, characterized by a state of insufficiently calcified tissue and bone loss, respe...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2004.05.003
更新日期：2004-08-01 00:00:00
abstract：:Estrogen sulfamates are promising hormones by oral administration. Therefore, generally applicable and convenient methods for the multigram synthesis of these derivatives are desirable. Numerous estra-1,3,5(10)-trienes derived from estrone, estradiol. 14 alpha,15 alpha-methylenestradiol, ethinylestradiol, and estriol ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(96)00200-0
更新日期：1996-12-01 00:00:00
abstract：:Synthesis of 7-aryl/allyl-substituted androstene derivatives 3a through 3g has been carried out by Grignard reaction on 3 beta,17 beta-diacetoxyandrost-5-en-7-one (2) with aryl/allyl magnesium bromide. Isomeric mixture of products 3b and 3c/3e and 3f/3h was separated by column chromatography. Stereochemical assignment...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(91)90005-g
更新日期：1991-09-01 00:00:00
abstract：:Two new 4-methyl-progesteroids, nodulisporisteriod A (1) and nodulisporisteriod B (2), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1), along with two related metabolites, demethoxyviridin (3) and inoterpene B (4). Their structures were determined by detailed spectrosc...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.05.007
更新日期：2013-09-01 00:00:00
abstract：:The hormone 1alpha,25(OH)2vitamin D3 (1,25-D) produces biological responses via both genomic and rapid mechanisms. The genomic responses are linked to a nuclear receptor, while the rapid responses are believed to utilize other signal transduction pathways that are likely linked to a putative cell membrane receptor for...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/s0039-128x(98)00091-9
更新日期：1999-01-01 00:00:00
abstract：:A technique has been developed in which progesterone may be measured by radioimmunoassay in unextracted serum. The method depends on the displacement of progesterone from serum binding proteins by danazol, [17 alpha-pregn-4-en-20-yno (2,3-d) isoxazol-17-ol], a compound which also blocks recombination of free progester...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(79)90021-7
更新日期：1979-02-01 00:00:00
abstract：:Two isomeric dimeric steroids, 3,3'-bis(methyl 3-hydroxyandrost-4-en-17-on-19-oate-3-yl), with symmetrical (alpha, alpha') and unsymmetrical structures (alpha,beta'), have been obtained by reduction of methyl androst-4-ene-3,17-dion-19-oate with zinc in aqueous acetic acid together with the major products, the isomeri...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(99)00108-7
更新日期：2000-04-01 00:00:00
