Abstract:
:The applications of sterically crowed trialkyksilyl ether derivatives to the analysis and characterization by thin-layer chromatography, gas chromatography and mass spectrometry, of metabolites of 2alpha, 3alpha-cyclopropano-5alpha-androstan-17beta-ol in the rabbit are described. These derivatives are complementary to the familiar trimethysilyl ether derivatives, but have greater hydrolytic stability (an advantage for TLC), generally give better GC separations, and have characteristic mass spectra. Isomer differentiation by GC and MS is also more readily achieved than via the TMSi ether derivatives. These properties should make SCTASi ethers useful derivatives for studies of steroid metabolism.
journal_name
Steroidsjournal_title
Steroidsauthors
Quilliam MA,Templeton JF,Westmore JBdoi
10.1016/0039-128x(77)90013-7subject
Has Abstractpub_date
1977-05-01 00:00:00pages
613-26issue
5eissn
0039-128Xissn
1878-5867pii
0039-128X(77)90013-7journal_volume
29pub_type
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