Abstract:
:The isolated perfused rat kidney allows a simultaneous kinetic study of both the renal metabolism and the urinary excretion of cortisol and its metabolites in the rat. In this system, cortisol was completely metabolized within 120 minutes. The main renal metabolites of cortisol (cortisone, 20 reduced cortisol and 20 reduced cortisone) were found in the recirculating perfusate and in urine. The formation of these metabolites was quantitatively evaluated and compared to a theoretical model.
journal_name
Steroidsjournal_title
Steroidsauthors
Reach G,Nakane H,Nakane Y,Auzan C,Corvol Pdoi
10.1016/0039-128x(77)90052-6subject
Has Abstractpub_date
1977-11-01 00:00:00pages
621-35issue
5eissn
0039-128Xissn
1878-5867pii
0039-128X(77)90052-6journal_volume
30pub_type
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