Abstract：
:Several derivatives of the arthropod moulting hormone have been synthesized which were coupled to AH Sepharose 4B yielding about 2 mumole ligand per g wet gel. As an indication of the suitability of the ligands for biological work the puff inducing capacity of their methyl esters was tested. The methyl ester of inokosterone-C-26-carboxylic acid possesses the highest biological activity; lower activities were obtained with the esters of ecdysterone-C-6-CM-oxime and ecdysterone hemisuccinates. Therefore, inokosterone-C-26-carbocylic acid should be a useful ligand for affinity chromatography of ecdysone recptors from insect tissues.
journal_name
Steroidsjournal_title
Steroidsauthors
Spindler KD,Hamann A,Spindler-Barth M,Ihne A,Beckers C,Emmerich Hdoi
10.1016/0039-128x(76)90088-xsubject
Has Abstractpub_date
1976-04-01 00:00:00pages
553-65issue
4eissn
0039-128Xissn
1878-5867pii
0039-128X(76)90088-Xjournal_volume
27pub_type
杂志文章相关文献
STEROIDS文献大全abstract：:This study aimed to develop a quantitative and in vivo magnetic resonance imaging (MRI) approach to investigate the muscle growth effects of anabolic steroids. A protocol of MRI acquisition on a standard clinical 1.5 T scanner and quantitative image analysis was established and employed to measure the individual muscl...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2007.12.011
更新日期：2008-04-01 00:00:00
abstract：:Circulation levels of estrone sulfate (E1S) and dehydroepiandrosterone sulfate (DHAS) have been measured in plasma using a radioimmunoassay for estrone and dehydroepiandrosterone following extraction and hydrolysis of the sulfate. The mean +/- SE concentrations of E1S and DHAS in normal men were 458 +/- 25 pg/ml and 1...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(79)80017-3
更新日期：1979-11-01 00:00:00
abstract：:A radioimmunoassay (RIA) method is described for the determination of 4-androstene-3, 11, 17-trione (11-oxo-androstenedione) in human plasma. 4-androstene-3, 11, 17-trione 3-(0-carboxymethyl) oxime-bovine serum albumin conjugate was used to generate highly specific antiserum in rabbits. Cross reactivities of several o...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(84)80013-6
更新日期：1984-07-01 00:00:00
abstract：:A radioimmunoassay for the quantitation of the sum of free, glucuronidated and urine is described. The method is reliable and accurate. Using this method, urinary excretion of 16 alpha-hydroxyestrone was determined in normal men, premenopausal women, and postmenopausal women. The values were compared to the urinary ex...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(89)90144-x
更新日期：1989-01-01 00:00:00
abstract：:The concentration of estrogens in the body fluids of women is highly variable, due to the menstrual cycle, circadian oscillations, and other physiological and pathological causes. To date, only the cyclic fluctuations of the principal estrogens (estradiol and estrone) have been studied, with limited outcome of general...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2019.108432
更新日期：2019-10-01 00:00:00
abstract：:The purpose of this study was to investigate the influence of plasma steroid-binding proteins on androgen metabolism in intact leukocytes prepared from normal male and female blood samples. Leukocyte preparations were incubated for 24 h at 37 degrees C with either labeled or unlabeled testosterone (T), 5 alpha-dihydro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(94)00042-b
更新日期：1995-02-01 00:00:00
abstract：:Estrogen levels in breast tumors of post-menopausal women are as much as 10 times higher than estrogen levels in plasma, presumably due to in situ formation of estrogen. The major source of estrogen in breast cancer cells may be conversion of estrone sulfate to estrone by the enzyme estrone sulfatase. Thus, inhibitors...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(98)00044-0
更新日期：1998-07-01 00:00:00
abstract：:Estradiol (E2), progesterone (P4), and oxytocin (OT) are important for the initiation of luteolysis in ruminants but the mechanisms involved are still poorly understood. The objective of this study was to determine if duration of exposure of bovine endometrial epithelial cells to P4 affected the response of the cells ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(03)00094-1
更新日期：2003-09-01 00:00:00
abstract：:3beta-Hydroxy sterols occurring at a concentration of at least 0.001% of the sterol mixtures of Pseudoplexaura porosa and Plexaura homomalla have been fractionated using a series of refined techniques and subsequently analyzed using combined gas chromatography-mass spectrometry (GC-MS) in the development of a procedur...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(76)90009-x
更新日期：1976-11-01 00:00:00
abstract：:Radioimmunoassay procedures have been adapted for the assay of progesterone, 17-hydroxyprogesterone, estradiol-17beta, and prostaglandin F in human corpus luteum. The method utilises a single homogenisation and extraction of the tissue followed by fractionation of the steroids on alumina, and separation of the prostag...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(75)90076-8
更新日期：1975-09-01 00:00:00
abstract：:The reaction of 23-oxotigogenin acetate with TMSOTf in THF afforded the corresponding bisnorcholanic lactone in 60% yield. The analogous reactions carried out in dichloromethane or benzene gave the rearranged products--the isomeric spirostanic ketone (10-15%) and bisfuran (40-42%). Similar products were also obtained ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2009.02.010
更新日期：2009-08-01 00:00:00
abstract：:The addition of molybdate to rabbit liver cytosol increased significantly the affinity of the glucocorticoid receptor for [3H] dexamethasone without influencing the concentration of binding sites. This effect was concentration dependent. Analysis of the binding data by curve-fitting and Scatchard plot revealed the occ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(84)90088-6
更新日期：1984-08-01 00:00:00
abstract：:Glucocorticoids (GCs) and progesterone have been employed as immunosuppressive agents during pregnancy for many years. Intracellular acidification by GCs is due to a rapid non-genomic inhibition of membrane Na(+)/H(+)-exchange 1 (NHE1) activity and is followed by immunosuppression of PHA-stimulated proliferation. NHE1...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2016.01.004
更新日期：2016-07-01 00:00:00
abstract：:17 beta-Hydroxysteroid dehydrogenase (HSD) was studied in endometrium removed surgically from intact female monkeys in the luteal phase of the menstrual cycle. Also castrated monkeys (N=20) implanted with estradiol (E2) and progesterone (P) in silastic capsules were used to investigate the hormonal dependence of this ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(79)90139-9
更新日期：1979-01-01 00:00:00
abstract：:Dehydroepiandrosterone (DHEA), an adrenal steroid, has a protective role against diabetes; however, its mechanisms of action are unknown. Here, we focus on the effect of DHEA on the activation of endothelial cells induced by a high concentration of glucose. Adhesion on U937 cells, expression of adhesion molecules, pro...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.11.010
更新日期：2012-02-01 00:00:00
abstract：:Urinary steroid profile analysis requires enzymatic hydrolysis of glucuronide and sulfate conjugates and this is achieved simultaneously using Helix pomatia juice (HPJ), but steroids with 3beta-hydroxy-5-ene structure undergo transformation and yield of 5alpha-reduced corticosteroid glucuronides is poor. We describe t...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2007.11.001
更新日期：2008-03-01 00:00:00
abstract：:Bioconversion of the aromatase inhibitor formestane (4-hydroxyandrost-4-ene-3,17-dione) (1) by the fungus Rhizopus oryzae ATCC 11145 resulted in a new minor metabolite 3,5α-dihydroxyandrost-2-ene-4,17-dione (2) and the known 4β,5α-dihydroxyandrostane-4,17-dione (3) as the major product. The structural elucidation and ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2016.07.003
更新日期：2016-09-01 00:00:00
abstract：:The main purpose of this review article is threefold (a) to try to address the question "why are two adrenal glucocorticoids, cortisol and corticosterone, secreted by humans and other mammalian species?", (b) to outline a hypothesis that under certain physiological conditions, corticosterone has additional biochemical...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2015.06.017
更新日期：2015-10-01 00:00:00
abstract：:Homogenates from human myometrium with an added NADPH regenerating system and ATP were incubated with 4-(14)C progesterone. Six metabolites were identified: 5alpha-pregnane-3, 20-dione, 5beta-pregnane-3, 20-dione, 3alpha-hydroxy-4-pregnen-20-one, 3beta hydroxy-4-pregnen-20-one. 20alpha-hydroxy-4-pregnen-3-one and 20be...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(77)90131-3
更新日期：1977-07-01 00:00:00
abstract：:Brassinosteroid (BR) phytohormones play indispensable roles in plant growth and development. Brassinolide (BL) and 24-epibrassinolide (24-epiBL) are the most active ones among the BRs reported thus far. Unfortunately, the extremely low natural content and intricate synthesis process limit their popularization in agric...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2015.09.002
更新日期：2015-12-01 00:00:00
abstract：:Two new 4-methyl-progesteroids, nodulisporisteriod A (1) and nodulisporisteriod B (2), were isolated from the extract of an endolichenic fungal strain Nodulisporium sp. (No. 65-17-2-1), along with two related metabolites, demethoxyviridin (3) and inoterpene B (4). Their structures were determined by detailed spectrosc...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.05.007
更新日期：2013-09-01 00:00:00
abstract：:Glucocorticoids are an important class of anti-inflammatory/immunosuppressive drugs. A crucial part of their anti-inflammatory action results from their ability to repress proinflammatory transcription factors such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1) upon binding to the glucocorticoid receptor ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2014.04.003
更新日期：2014-07-01 00:00:00
abstract：:A series of clickable bile acid-nucleosides conjugates linked directly or via amino acid linker were synthesized, and characterized by spectroscopic techniques such as 1H NMR, 13C NMR, FT-IR, HRMS and HPLC. The synthesized compounds 6a-p were screened for their in vitro anticancer property against a panel of three can...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2018.09.006
更新日期：2018-11-01 00:00:00
abstract：:Initial excretion studies with orally administered [monoethyl-1-3H] DES demonstrated the feces to be the principal mode of elimination of DES in the C3H mouse. Metabolic studies with tritiated DES and/or [UL-14C] DES were performed with orally dosed C3H high (MTV+) and low (MTV-) titer MMTV female mice. Extraction and...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(78)90029-6
更新日期：1978-04-01 00:00:00
abstract：:The concentration of testosterone (T) in the peripheral plasma of laboratory mice is extremely variable. This variability is already evident at 20--25 days of age and is not eliminated by brief or chronic exposure to male or female mice, or by isolation. The variation in T levels in plasma samples collected from the s...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(75)90107-5
更新日期：1975-12-01 00:00:00
abstract：:21-Hydroxypregnenolone and its metabolite 5-pregnene-3 beta, 20 alpha 21-triol have been measured in the sulfate fraction of neonatal urine. These two steroids are the major two 21-hydroxylated 5-pregnenes produced by neonates and are almost exclusively excreted as disulfates. The excretions of these steroids by norma...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(87)90006-7
更新日期：1987-04-01 00:00:00
abstract：:Adrenal function and aging have been the object of intense interest in recent years. In this study we analyzed morning (08:00 h) serum cortisol concentrations from a sample of Chinese subjects aged from 31 to 110 years. These levels differed according to age, health status and sex, although the sex difference was conf...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(03)00083-7
更新日期：2003-08-01 00:00:00
abstract：:Novel deoxycholic acid (DCA) derivatives were stereoselectively synthesised with -OH and -CH2SR moieties at the C-3 position, where R was a substituted aryl [2-aminophenyl (8) or 4-chlorophenyl (9)] or hetaryl [1-methylimidazolyl (5), 1,2,4-triazolyl (6), 5-amino-1,3,4-thiadiazolyl (7), pyridinyl (10) or pyrimidinyl (...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2017.08.016
更新日期：2017-11-01 00:00:00
abstract：:The effects of progesterone, its agonists (progestin RU-5020, glucocorticoid RU-26988) and antagonist (antiprogesterone, anti-glucocorticoid RU-486) were tested on isolated fat cells in vitro. When added to the incubation medium, all four steroids decreased basal glucose oxidation. The inhibitory effect of the steroid...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(88)90125-0
更新日期：1988-11-01 00:00:00
abstract：OBJECTIVE:The cut-off value for salivary cortisol measurement for the diagnosis of Cushing's syndrome (CS) may depend both on the severity of the disease and the composition of control group. Therefore, we examined the utility of midnight salivary cortisol measurements in patients who were evaluated for signs and sympt...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2010.08.007
更新日期：2011-01-01 00:00:00
