Abstract:
:A radioimmunoassay for the quantitation of the sum of free, glucuronidated and urine is described. The method is reliable and accurate. Using this method, urinary excretion of 16 alpha-hydroxyestrone was determined in normal men, premenopausal women, and postmenopausal women. The values were compared to the urinary excretion of estrone and estradiol. In two women, the urinary excretion of the three estrogens was measured in daily samples throughout a normal menstrual cycle. We conclude that 16 alpha-hydroxyestrone is a quantitatively important urinary estrogen. Inclusion of the measurement of 16 alpha-hydroxyestrone should yield a more accurate assessment of estrogen metabolism.
journal_name
Steroidsjournal_title
Steroidsauthors
Naganuma H,Hershcopf RJ,Michnovicz JJ,Miyairi S,Bradlow HL,Fishman Jdoi
10.1016/0039-128x(89)90144-xsubject
Has Abstractpub_date
1989-01-01 00:00:00pages
37-48issue
1-2eissn
0039-128Xissn
1878-5867pii
0039-128X(89)90144-Xjournal_volume
53pub_type
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