Abstract:
:The synthesis of the esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) with three bile acids and of the cholesteryl carbonate of norethisterone are described. :This article reports the synthesis of the esters of norethisterone (17 alpha-ethynl-17beta-hydroxyestr-4-en-3-one) with 3 bile acids and of the cholesteryl carbonate of norethisterone. The compounds were prepared by reacting the thallium salt of norethisterone with an acid chloride in an organic solvent. Compounds prepared included: t-butyl dimethylsilyl ether of 3alpha-formyloxy-5beta-cholan-24oic acid; 3alpha-formyloxy-5beta-cholan-24-oic acid chloride; norethisterone ester of 3alpha-formyloxy-5beta-cholan-24-oic acid; norethisterone ester of 3alpha-formyloxy-5 beta-cholan-24-oic acid; norethisterone ester of 3alpha, 12alpha-diformyloxy-5beta-cholan-24-oic acid; norethisterone ester of 3 alpha, 7alpha, 12alpha-triformyloxy-5 beta-cholan-24-oic acid; norethisterone ester of 3 beta-acetoxypregn-5-en-20alpha-carboxylic acid; and norethisterone cholesteryl carbonate. This experimentation was part of a program initated by the World Health Organization for the synthesis and screening of new compounds that might be useful as long-acting, injectable contraceptives.
journal_name
Steroidsjournal_title
Steroidsauthors
Herz JE,Sandoval Jdoi
10.1016/0039-128x(83)90103-4subject
Has Abstractpub_date
1983-03-01 00:00:00pages
327-31issue
3eissn
0039-128Xissn
1878-5867pii
0039-128X(83)90103-4journal_volume
41pub_type
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