Abstract:
:Glucocorticoids (GCs) are widely prescribed as adjuvant therapy for breast cancer patients. Unlike other steroid hormone receptors, the GC receptor is not considered an oncogene. Research in the past few years has revealed the complexity of GC-mediated signaling, but it remains puzzling whether GCs promote or inhibit tumor progression in different cancer types. Here we evaluated the potential of using a synthetic GC, dexamethasone (DEX), in the treatment of breast cancer. We found that the administration of low-dose DEX suppressed tumor growth and distant metastasis in the MCF-7 and MDA-MB-231 xenograft mouse model, whereas treatment with high-dose DEX enhanced tumor growth and metastasis, respectively. Treatment of breast cancer cells with DEX inhibited cell adhesion, migration, and invasion in a dose-dependent manner. The DEX-mediated inhibition of cell adhesion, migration, and invasion is partly through induction of microRNA-708 and subsequent Rap1B-mediated signaling in MDA-MB-231 cells. On the other hand, in MCF-7 cells, DEX-suppressed cell migration is independent from microRNA-708 mediated signaling. Overall, our data reveal that DEX acts as a double-edged sword during breast-cancer progression and metastasis: Lower concentrations inhibit breast cancer tumor growth and metastasis, whereas higher concentrations may play an undesired role to promote breast cancer progression.
journal_name
Steroidsjournal_title
Steroidsauthors
Pang JM,Huang YC,Sun SP,Pan YR,Shen CY,Kao MC,Wang RH,Wang LH,Lin KTdoi
10.1016/j.steroids.2020.108738subject
Has Abstractpub_date
2020-12-01 00:00:00pages
108738eissn
0039-128Xissn
1878-5867pii
S0039-128X(20)30164-1journal_volume
164pub_type
杂志文章相关文献
STEROIDS文献大全abstract::Glucocorticoid receptor binding was compared in liver cytosol preparations from spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats using homologous displacement of [3H]dexamethasone. At 5 degrees C, there was no difference in receptor binding affinity or concentration between strains for dexamethasone, ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)00011-z
更新日期:1995-01-01 00:00:00
abstract::The concentration of estrogens in the body fluids of women is highly variable, due to the menstrual cycle, circadian oscillations, and other physiological and pathological causes. To date, only the cyclic fluctuations of the principal estrogens (estradiol and estrone) have been studied, with limited outcome of general...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2019.108432
更新日期:2019-10-01 00:00:00
abstract::Cholesterol side-chain cleavage (CSCC) and aromatase activities were measured in luteal mitochondria and tissue pieces, respectively, from rhesus monkeys on days 22, 49, 128 and 160 of gestation. CSCC activity did not vary significantly during gestation and thus probably does not respond to chorionic gonadotropin whic...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(77)90042-3
更新日期:1977-02-01 00:00:00
abstract::As demonstrated for pregnenolone, saturated ketones are conveniently alpha-hydroxymethylated by their transformation into a lithium enolate and by the reaction of the latter with formaldehydr. The 17-hydroxymethylpregnenolone prepared by this method in very good yield was readily converted to 17-hydroxymethylprogester...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(79)80021-5
更新日期:1979-11-01 00:00:00
abstract::A rapid and efficient synthesis of 6E-hydroximinosteroid homodimers is described. The two new compounds were linked at position 3 of the steroid nucleus via a ruthenium catalyzed cross-metathesis reaction. The cytotoxic activity of these compounds was evaluated in vitro on human lung carcinoma A549 (ATCC CCL-185), col...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.03.014
更新日期:2007-10-01 00:00:00
abstract::The 7 alpha-methyl substituent is reported to increase the binding affinity of estradiol for the estrogen receptor (ER). In order to evaluate whether this substituent would improve the in vitro binding characteristics and the in vivo tissue distribution of 18F labeled estrogens that we are developing as positron emiss...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(94)90043-4
更新日期:1994-01-01 00:00:00
abstract::Seventeen cholesteryl alkyl ethers were synthesized through alcoholysis of cholesterol p-toluenesulfonate. This method was found superior to the etherification of sodium or potassium cholesterylate with alkyl halides or methanesulfonates, especially for the preparation of long-chain unsaturated aklyl ethers of [7(m)-3...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90109-9
更新日期:1980-01-01 00:00:00
abstract::Data are presented on the urinary corticosteroid metabolic profile of the mouse strain 129/svJ. Through the use of GC/MS we have characterized, or tentatively identified corticosterone (Kendall's compound B) metabolites of both the 11beta-hydroxy and 11-carbonyl (compound A) series in urine. Full mass spectra of the m...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.04.004
更新日期:2008-10-01 00:00:00
abstract::Contraceptive methods for breastfeeding women should be safe for the mother and infant and should not interfere with lactation. Progestin-only methods meet these conditions and can be used from the sixth week postpartum. Because all progestins are excreted in milk, those that are insufficiently active by the oral rout...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(00)00125-2
更新日期:2000-10-01 00:00:00
abstract::A first assay based on stable isotope dilution/gas chromatography-mass spectrometry (ID/GC-MS) has been developed for plasma 11-deoxycortisol (Reichstein's compound S), the leading hormonal marker of 11beta-hydroxylase deficiency. A suitable internal standard being unavailable, we synthesized dideuterated 11-deoxycort...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(02)00052-1
更新日期:2002-09-01 00:00:00
abstract::The metabolism of testosterone (T) was studied in normal adult male rats using a constant infusion of trace amounts of the 3H-steroid into a tail vein for 3 h in order to attain a state of equilibrium. Samples of plasma, liver, kidney, prostate, seminal vesicles and muscle were analysed for 3H-testosterone, 3H-5alpha-...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(75)90011-2
更新日期:1975-07-01 00:00:00
abstract::The mass spectral elimination of water in epimeric 1,3-diols of vitamin D3 (colecalciferol) series has been investigated. It was found that the mass spectra of these steroisomers differ sharply in the relative intensities of the ions M-H2O (m/e 382) and a-H2O (m/e +/- 34), where ion a (formed via formal cleavage of th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(79)90039-4
更新日期:1979-05-01 00:00:00
abstract::A trisulfated derivative of 24,25,26,26-tetramethyl-5 alpha-cholest-23E-ene-2 alpha, 3 beta, 6 alpha-triol (sokotrasterol sulfate) has been isolated from the sponge Halichondriidae gen. sp., collected near Sokotra Island (Arabian Sea), and its structure has been elucidated. The side chain of the new steroid involves a...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(83)90039-9
更新日期:1983-09-01 00:00:00
abstract::The preparation of 9alpha, 11xi-tritiated 17alpha-ethinyl estradiol, mestranol, estradiol-17beta, and norethindrone are described. Estrone-3-methyl ether was employed as starting material, and ethinylation with lithium acetylide-ethylene diamine resulted in 95% mestranol. Demethylation of mestranol with boron tribro...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(71)90028-6
更新日期:1971-08-01 00:00:00
abstract::The synthesis of 16 alpha-3H androgens and estrogens is described. 1-(3H)-Acetic acid in the presence of zinc dust reacts with 16 alpha-bromo-17-ketosteroids to produce 16 alpha-3H-17-ketosteroids. This chemical reaction was used to prepare 16 alpha-3H-dehydroepiandrosterone (I) and 16 alpha-3H-estrone acetate (XI) fr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(81)80016-5
更新日期:1981-02-01 00:00:00
abstract::Periodontitis is a complication of diabetes mellitus, and the two diseases are highly associated with the dysfunction of inflammatory mediators. 25-hydroxyvitamin D(3) (25(OH)D(3)) plays a pivotal role in inflammatory modulation, but little is known about its effects on the progression of diabetic periodontitis and th...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.10.015
更新日期:2013-02-01 00:00:00
abstract::1,25-Dihydroxyvitamin D(3) (1,25D) regulates gene transcription through a nuclear vitamin D receptor (VDR) which acts as a ligand-regulated transcription factor. Some structural vitamin D analogs (VDAs) are selective in their biological actions, because they retain cell-differentiating potential, while their calcemic ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.06.010
更新日期:2008-12-22 00:00:00
abstract::Polycystic ovary syndrome (PCOS) is associated with multiple risk factors for cardiovascular disease (CVD), including insulin resistance, type 2 diabetes mellitus, obesity, hypertension, and dyslipidemia. In addition, hyperandrogenism may contribute to the pathogenesis of CVD, independent of obesity and insulin resist...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.08.005
更新日期:2012-11-01 00:00:00
abstract::2,2,6,6-Tetramethyl piperidine-N-oxyl nitroxyls are known to partition between aqueous and lipid phases, thus serving as probes to study membrane dynamics. The synthesis of a novel steroidal spin label, 3alpha-hydroxycholan-24-yl-(2",2",6",6"-tetramethyl-N-oxyl)p iperidyl butan-1',4'-dioate, containing 2,2,6,6-tetrame...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00072-0
更新日期:1999-12-01 00:00:00
abstract::A novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from cheap and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, bases and reaction temperatures of the route were investigated and optimized. In the straightforward route...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2020.108600
更新日期:2020-05-01 00:00:00
abstract::Spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, were synthesized from commercially available stigmasterol by a four steps reactions. In addition, the effects of these phytosterols on cell growth and mitochondrial activity were evaluated on 158N murine oligodendrocytes, C6...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2015.01.005
更新日期:2015-07-01 00:00:00
abstract::Studies were carried out on the effect of oxygen tension on progesterone (P) accumulation in rat granulosa cell cultures. At 1-2% oxygen, basal, luteinizing hormone (LH)-stimulated, and follicle stimulating hormone (FSH)-stimulated P accumulations were 20, 18, and 11%, respectively, of P levels at 20% oxygen. Basal P ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(89)90047-0
更新日期:1989-11-01 00:00:00
abstract::C17-20Lyase and 21-hydroxylase activities were measured during late gestation in the rhesus monkey (Macaca mulatta) fetal adrenal. Activities were assessed in 10,000 x g supernatants with 17-hydroxyprogesterone and NADPH as substrates. Although conversion of [14C]17-hydroxyprogesterone to [14C]androstenedione was note...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(81)90036-2
更新日期:1981-08-01 00:00:00
abstract::The preparation of 3-oxo-4-azasteroid from A-nor-3,5-secosteroid-3-oic acid is described in a solventless condition catalysed by Lewis acid under microwave irradiation. We utilized urea as an environmentally benign source for the generation of ammonia for the aza cyclization reaction. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2008.01.022
更新日期:2008-07-01 00:00:00
abstract::Labeled beta-muricholic acid was obtained from germfree rats given [24-14C]-chenodeoxycholic acid. It was crystallized with the same unlabeled bile acid extracted from germfree rat pooled biles. Five patients fitted with a T-tube after cholecystectomy were given orally 100 mg of the bile acid. Metabolites of beta-muri...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(85)90006-6
更新日期:1985-05-01 00:00:00
abstract::Breast cancer risk is strongly related to several reproductive and hormonal factors, but the nature of the effects of endogenous oestrogens has been difficult to establish. Data are now available from several large prospective studies with biobanks of stored serum, enabling better characterization of the associations ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.02.029
更新日期:2011-07-01 00:00:00
abstract::7 alpha- and 7 beta-carboxymethyl-derivatives of 17-hydroxyprogesterone and 11-deoxycortisol have been synthesized. After coupling to bovine serum albumin, they were used to elicit antibodies in rabbits. No major difference in the steroid specificity of the antisera was observed when either 7 alpha- or 7 beta-epimers ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90112-9
更新日期:1980-01-01 00:00:00
abstract::Deltonin is a steroidal saponin which could suppress tumor growth through suppressing angiogenesis, but the mechanisms have not been directly elucidated yet. In the present study, we showed that deltonin inhibited the proliferation of primary cultured human umbilical vein endothelial cells (HUVECs) in vitro; notably, ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2014.12.019
更新日期:2015-04-01 00:00:00
abstract::Glucocorticoids (GCs) are essential steroid hormones that regulate numerous metabolic and homeostatic functions in almost all physiological systems. Synthetic glucocorticoids are among the most commonly prescribed drugs for the treatment of various conditions including autoimmune, allergic and inflammatory diseases. G...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2017.11.002
更新日期:2018-05-01 00:00:00
abstract::By the conventional methods of gas liquid chromatography (GLC) as well as mass spectrometry, 3beta,7alpha-dihydroxychol-5-en-24-oic acid (delta5-acid), a key intermediate of chenodeoxycholic acid biogenesis and its metabolic by-product, 3alpha,7alpha-dihydroxychol-4-en-24-oic acid (delta4-acid) have not yet been ident...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(78)90102-2
更新日期:1978-07-01 00:00:00