Abstract：
:Desoxymethyltestosterone (DMT; 17β-hydroxy-17α-methyl-5α-androst-2-ene) is a designer steroid present in hormonal supplements distributed illegally as such or in combination with other steroids, for self-administration. It figures on the list of substances prohibited in sports and its detection in athlete's urine samples is based upon the presence of the parent compound or the main urinary metabolite, which has not been characterized yet. Following its isolation from cultures of human fresh hepatocytes and S9 fractions of liver homogenates, we were able to identify this metabolite as being 17α-methyl-2β,3α,17β-trihydroxy-5α-androstane. Other minor metabolites were also characterized. The production, isolation, NMR, mass spectral analyses and chemical synthesis are presented.
journal_name
Steroidsjournal_title
Steroidsauthors
Gauthier J,Poirier D,Ayotte Cdoi
10.1016/j.steroids.2012.02.008subject
Has Abstractpub_date
2012-05-01 00:00:00pages
635-43issue
6eissn
0039-128Xissn
1878-5867pii
S0039-128X(12)00066-9journal_volume
77pub_type
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