Abstract:
:The purpose of this study was to determine the short-term effects of progesterone action on estrogen receptor (Re) levels in the rat uterus. Ovariectomized, adrenalectomized rats were maintained on subcutaneous Silastic implants containing crystalline estradiol. Progesterone treatment with serum estradiol maintenance caused a rapid decrease (within 4 h) of total Re, attributable to loss of nuclear Re without a significant change in cytosol Re levels. Removal of estradiol implants resulted in an increase in total Re and cytosol Re at all time periods studied without a significant decrease in nuclear Re until 8 h. Combined estradiol withdrawal and progesterone treatment resulted in lower total Re levels and a more rapid decrease in nuclear Re than with estradiol withdrawal alone. These results demonstrate that progesterone rapidly and selectively decreases nuclear Re levels in rat uterus and suggest that this process is not dependent on cytosol Re or serum estradiol levels.
journal_name
Steroidsjournal_title
Steroidsauthors
Okulicz WC,Evans RW,Leavitt WWdoi
10.1016/0039-128x(81)90047-7subject
Has Abstractpub_date
1981-04-01 00:00:00pages
463-70issue
4eissn
0039-128Xissn
1878-5867pii
0039-128X(81)90047-7journal_volume
37pub_type
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