High concentrations of conjugated bile acids inhibit bacterial growth of Clostridium perfringens and induce its extracellular cholylglycine hydrolase.

abstract：:An efficient method to prepare 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione in one pot was reported. Treatment of 9-bromide-11-hydroxypregna-1, 4, 16-trien-3, 20-dione with Raney Ni in absolute ethanol afforded 5, 9-cyclo-1, 11-oxido-pregn-16-ene-3, 20-dione by two annulation reactions in reasonable yield. The abso...

journal_title：Steroids

authors： Jia P,Wu X,Yu Y,Zhang G

更新日期：2009-02-01 00:00:00

abstract：:A highly active inhibitor of the binding of estrone and estradiol-17beta to rat alpha-fetoprotein is demonstrated for the first time in embryo, immature and adult rat sera as well as in fetal and adult human sera. The competitive character and the narrow specificity of this inhibition effect is shown. The major compou...

journal_title：Steroids

authors： Benassayag C,Vallette G,Delorme J,Savu L,Nunez EA,Jayle MF

更新日期：1977-12-01 00:00:00

abstract：:Testosterone (17 beta -hydroxy-4-androsten-3-one ; T) and dihydrotestosterone (17 beta -hydroxy-5 alpha -androstan-3-one ; DHT) concentrations were determined by radioimmunoassay in different fetal tissues taken from male guinea-pigs. Androgen concentrations were maximal in the components of the Wolffian duct (vas def...

journal_title：Steroids

authors： Rigaudière N

更新日期：1981-08-01 00:00:00

abstract：:Ischemic heart disease (IHD) continues to be the most common cause of death globally, although mortality rates are decreasing with significant advances in treatment. Higher prevalence of co-morbidities in women only partly explains the lack of decrease in mortality rates in younger women due to. Until recently there h...

journal_title：Steroids

authors： Mihailidou AS,Ashton AW

更新日期：2014-12-01 00:00:00

abstract：:Circulating levels (mean +/- SD) of estrone sulfate (E1S), estrone (E1) and estradiol-17 beta (E2) were measured in normal and cirrhotic postmenopausal women matched for body weight and age. In cirrhotic postmenopausal women, the E1S concentrations (201 +/- 46 pg/ml), while both E1 and E2 levels showed an increase (46...

journal_title：Steroids

authors： Jasonni VM,Bulletti C,Bolelli GF,Franceschetti F,Bonavia M,Ciotti P,Flamigni C

更新日期：1983-05-01 00:00:00

abstract：:Nucleocytoplasmic shuttling of glucocorticoid receptors (GRs) is disrupted in v-mos-transformed cells leading to the redistribution of hormone-bound receptors from the nuclear to cytoplasmic compartments. We show here that GRs from v-mos-transformed cells are hyperphosphorylated on a specific peptide and maintain horm...

journal_title：Steroids

authors： Borror KC,Garabedian MJ,DeFranco DB

更新日期：1995-05-01 00:00:00

abstract：:Human placental estradiol 17 beta-dehydrogenase (E.C. 1.1.1.62) was inactivated at pH 6.3 by 3-bromo [2'-14C] acetoxy-1,3,5(10) estratrien-17-one, a know substrate. The affinity-alkylated enzyme was then hydrolyzed by trypsin. Radioactive peptides were initially isolated by gel filtration and identified according to w...

journal_title：Steroids

authors： Murdock GL,Warren JC

更新日期：1982-02-01 00:00:00

abstract：:Within the adult female, estrogen signaling is well-described as an integral component of the physiologically significant hypothalamic-pituitary-gonadal axis. In rodents, the timing of ovulation is intrinsically entwined with the display of sexual receptivity. For decades, the importance of estradiol activating intrac...

journal_title：Steroids

authors： Tonn Eisinger KR,Larson EB,Boulware MI,Thomas MJ,Mermelstein PG

更新日期：2018-05-01 00:00:00

abstract：:The properties of 5-ene-3 beta hydroxysteroid oxidoreductase (3 beta-HSD) from human placental homogenates were studied in vitro. The apparent Michaelis constants for 3 beta-HSD with the substrates pregnenolone (delta 5P) and dehydroepiandrosterone (DHA) were 170 nM and nM respectively. The optimal pH for both these s...

journal_title：Steroids

authors： Yoshida N

更新日期：1979-01-01 00:00:00

abstract：:A rapid and efficient synthesis of 6E-hydroximinosteroid homodimers is described. The two new compounds were linked at position 3 of the steroid nucleus via a ruthenium catalyzed cross-metathesis reaction. The cytotoxic activity of these compounds was evaluated in vitro on human lung carcinoma A549 (ATCC CCL-185), col...

journal_title：Steroids

authors： Rega M,Jiménez C,Rodríguez J

更新日期：2007-10-01 00:00:00

abstract：:A direct competitive heterologous enzyme-linked immunosorbent assay (ELISA) was developed and validated to determine follicular fluid estradiol levels of different antral follicular sizes (small, medium, and large) obtained from the ovaries of heifers in the follicular phase of the estrous cycle. Polyclonal antiestrad...

journal_title：Steroids

authors： Silván G,Illera JC,Illera M

更新日期：1993-07-01 00:00:00

abstract：:The giant freshwater prawn, Macrobrachium rosenbergii, is important to many Asian countries due to its high economic value as an aquaculture product. With demand increasing, there is requirement for a better understanding of the biosynthetic components that regulate its growth and reproduction, including steroids, in ...

journal_title：Steroids

authors： Thongbuakaew T,Siangcham T,Suwansa-ard S,Elizur A,Cummins SF,Sobhon P,Sretarugsa P

更新日期：2016-03-01 00:00:00

abstract：:Bile acid salts are biosurfactants which form mixed micelles with phospholipids in vertebrates. These mixed micelles are suitable for solubilisation of cholesterol. For therapeutic purposes some bile acid salts as sodium ursocholate are used. However, bile acid anions possess low capacity for solubilisation of cholest...

journal_title：Steroids

authors： Poša M,Bjedov S,Sebenji A,Sakač M

更新日期：2014-08-01 00:00:00

abstract：:Bioassays were conducted to determine various endocrinological properties of two spirolactone derivatives, 4',5'-dihydrospiro-[estr-4-ene-17,2'(3'H)-furan]-3-one (Compound I) and dispiro[cyclopropane-1,6'-estr-4'-ene-17',2"(3"h)-furan]-3'-one (Compound II). They proved to be very potent estrogen antagonists in immatur...

journal_title：Steroids

authors： Brooks JR,Steelman SL,Patanelli DJ

更新日期：1977-06-01 00:00:00

abstract：:The concentration of testosterone (T) in the peripheral plasma of laboratory mice is extremely variable. This variability is already evident at 20--25 days of age and is not eliminated by brief or chronic exposure to male or female mice, or by isolation. The variation in T levels in plasma samples collected from the s...

journal_title：Steroids

authors： Bartke A,Dalterio S

更新日期：1975-12-01 00:00:00

abstract：:Counterfeiting and adulteration of pharmaceuticals is a prevalent problem worldwide and represents a major health risk to the population, with anabolic steroids being one of the main classes of drugs consumed and obtained from dubious sources. In this work, we propose the use of the 1H NMR technique to evaluate formul...

journal_title：Steroids

authors： Ribeiro MVM,Boralle N,Felippe LG,Pezza HR,Pezza L

更新日期：2018-10-01 00:00:00

abstract：:A cytochrome P450-deficient mutant of the pathogenic fungus, Candida albicans, which accumulates exclusively 14 alpha-methylsterols in place of the normal end product sterol, ergosterol, was examined for alterations in membrane fluidity by electron paramagnetic resonance. The results using four nitroxyl spin labels in...

journal_title：Steroids

authors： Lees ND,Kleinhans FW,Broughton MC,Pennington DE,Ricker VA,Bard M

更新日期：1989-03-01 00:00:00

abstract：:Two unnatural steroid sapogenins bearing a furospirostane side chain were prepared starting from the readily available spirostane sapogenins, tigogenin and diosgenin following a synthetic protocol that included: (i) introduction of a carbonyl group at position C-23, (ii) diacetoxyiodobenzene-induced F-ring contraction...

journal_title：Steroids

authors： Sánchez-Flores J,Romero-Ávila M,Rosado-Abón A,Flores-Álamo M,Iglesias-Arteaga MA

更新日期：2013-09-01 00:00:00

abstract：:The mode of action of steroid hormones has been extended in recent years. In addition to their classical nuclear action (acting as transcription factors), they can also regulate cell-signaling phosphorylation cascades and exert actions that are initiated at the membrane and which, in most cases, are rapid. Even though...

journal_title：Steroids

authors： Kampa M,Pelekanou V,Castanas E

更新日期：2008-10-01 00:00:00

abstract：:As demonstrated for pregnenolone, saturated ketones are conveniently alpha-hydroxymethylated by their transformation into a lithium enolate and by the reaction of the latter with formaldehydr. The 17-hydroxymethylpregnenolone prepared by this method in very good yield was readily converted to 17-hydroxymethylprogester...

journal_title：Steroids

authors： Mukherjee D,Engel CR

更新日期：1979-11-01 00:00:00

abstract：:This study examined the role of protein kinase C enzymatic activity as a physiologic determinant of stromal cell death in decidua basalis (DB) during pregnancy. The expression of epidermal growth factor receptor (EGF-R) and Bcl2 was used as an indicator of stromal cell proliferation/survival, whereas Bax and the occur...

journal_title：Steroids

authors： Ogle TF,Dai D,George P

更新日期：1999-09-01 00:00:00

abstract：:In humans, the onset of adrenache has been found to occur with the appearance of the zona reticularis, the inner zone of the adrenal cortex. Since an increase in the volume of adrenal cortex during maturation in the guinea pig has been associated with the growth of the zona reticularis, we were interested in investiga...

journal_title：Steroids

authors： Bélanger B,Caron S,Boudou P,Fiet J,Bélanger A

更新日期：1992-02-01 00:00:00

abstract：:Radioimmunoassay procedures have been adapted for the assay of progesterone, 17-hydroxyprogesterone, estradiol-17beta, and prostaglandin F in human corpus luteum. The method utilises a single homogenisation and extraction of the tissue followed by fractionation of the steroids on alumina, and separation of the prostag...

journal_title：Steroids

authors： Shutt DA,Shearman RP,Lyneham RC,Clarke AH,McMahon GR,Goh P

更新日期：1975-09-01 00:00:00

abstract：:A series of final twelve propanoyloxy derivatives of 5β-cholan-24-oic acid (O-propanoyl derivatives of cholic acid) as potential drug absorption modifiers (skin penetration enhancers, intestinal absorption promoters) was generated by multistep synthesis. Structure confirmation of all generated compounds was accomplish...

journal_title：Steroids

authors： Coufalová L,Mrózek L,Rárová L,Plaček L,Opatřilová R,Dohnal J,Král'ová K,Paleta O,Král V,Drašar P,Jampílek J

更新日期：2013-05-01 00:00:00

abstract：:A facile method for the synthesis of a series of new steroidal 3-thioxamides from the 3-oxo compound, variously substituted at the 17 position, is described. The "one pot" reaction, using Lawesson's reagent (4-methoxyphenylthionophosphine sulphide dimer) in dichloromethane solution, gives the desired compounds with a ...

journal_title：Steroids

authors： Grisenti P,Magni A,Manzocchi A,Ferraboschi P

更新日期：1997-06-01 00:00:00

abstract：:Sleep apnea is a disorder, which increasingly affects people worldwide. Whether the associated hypoxic events during sleep are central or obstructive in origin, the end result is excessive daytime sleepiness and an increased risk for several comorbidities, such as cardiovascular and neurodegenerative disorders. Sleep ...

journal_title：Steroids

authors： Snyder B,Cunningham RL

更新日期：2018-05-01 00:00:00

abstract：:Biotransformation of danazol (1) (17β-hydroxy-17α-pregna-2,4-dien-20-yno-[2,3-d]-isoxazole) with Cunninghamella blakesleeana yielded three new metabolites 2-4 and a known metabolite 5. These metabolites were identified as 14β,17β-dihydroxy-2-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2), 1α,17β-dihydroxy-17α-pregna-2...

journal_title：Steroids

authors： Baydoun E,Atia-tul-Wahab,Mehmood H,Ahmad MS,Malik R,Smith C,Choudhary MI

更新日期：2016-01-01 00:00:00

abstract：:The synthesis of delta 7,9(11)-lanostadiene derivatives functionalized at C(32) starting from 3 beta-acetoxy-7 alpha,32-epoxylanostan-11-one has been presented. The delta 7,9(11) moiety was efficiently introduced in three steps in 71% yield by the regioselective abstraction of allylic 8 beta hydrogen. The formyl group...

journal_title：Steroids

authors： Solaja BA,Dermanović M,Lim DM,Paik YK,Tinant B,Declerq JP

更新日期：1997-11-01 00:00:00

abstract：:The Na-K-2Cl cotransporter (NKCC2) regulates sodium transport along the thick ascending limb of Henle's loop and is important in control of sodium balance, renal concentrating ability and renin release. To determine if there are sex differences in NKCC2 abundance and/or distribution, and to evaluate the contribution o...

journal_title：Steroids

authors： Musselman TM,Zhang Z,Masilamani SM

更新日期：2010-11-01 00:00:00

abstract：:The 7 alpha-methyl substituent is reported to increase the binding affinity of estradiol for the estrogen receptor (ER). In order to evaluate whether this substituent would improve the in vitro binding characteristics and the in vivo tissue distribution of 18F labeled estrogens that we are developing as positron emiss...

journal_title：Steroids

authors： VanBrocklin HF,Liu A,Welch MJ,O'Neil JP,Katzenellenbogen JA

更新日期：1994-01-01 00:00:00