Abstract:
:Sleep apnea is a disorder, which increasingly affects people worldwide. Whether the associated hypoxic events during sleep are central or obstructive in origin, the end result is excessive daytime sleepiness and an increased risk for several comorbidities, such as cardiovascular and neurodegenerative disorders. Sleep apnea is diagnosed more frequently in men than women, suggesting a role of sex hormones in the pathology of the disease. Furthermore, there are sex differences in the development and progression of comorbid diseases associated with sleep apnea. Therefore, treatment of sleep apnea may be clinically relevant for prevention of subsequent sex-specific comorbid disorders. While the impact sleep apnea has on cardiovascular events has been the subject of many research studies, the role of sleep apnea in neurodegeneration is less established. Here we review known risk factors for sleep apnea and the implications of the observed sex differences in this disease. We also summarize the evidence and mechanisms for how sleep apnea may contribute to the onset of neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease.
journal_name
Steroidsjournal_title
Steroidsauthors
Snyder B,Cunningham RLdoi
10.1016/j.steroids.2017.12.006subject
Has Abstractpub_date
2018-05-01 00:00:00pages
28-33eissn
0039-128Xissn
1878-5867pii
S0039-128X(17)30232-5journal_volume
133pub_type
杂志文章,评审相关文献
STEROIDS文献大全abstract::A number of progesterone derivatives, having a 17 alpha-acetoxy group and various functions at C-3 and C-6, interact at the cardiac glycoside (CG) binding site, using [3H]ouabain in a radioligand binding assay (RBA) with membranes from dog myocardium. We now report on results of structure-activity studies concerned wi...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(87)90012-2
更新日期:1987-04-01 00:00:00
abstract::Although exogenous glucocorticoids (GC) play a role in the regulation of bone marrow mesenchymal stem/stromal cells (MSCs) proliferation and differentiation, the function of endogenous GC is not well understood. The purpose of this study was to investigate the effect of the blockage of endogenous GC using RU486, an an...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.10.017
更新日期:2012-01-01 00:00:00
abstract::There are currently two main candidates for the membrane receptor for 1,25(OH)2D3: the 1,25D3-MARRS protein/ERp57; and the classical VDR. The 1,25D3-MARRS protein is essential for hormone-stimulated phosphate and calcium uptake in chick intestinal cells, whereas the VDR is not. The 1,25D3-MARRS protein also shows a hi...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2005.02.005
更新日期:2005-05-01 00:00:00
abstract::The steroid hormone dehydroepiandrosterone (DHEA) has beneficial effects on vascular function, survival of neurons, and fatty acid metabolism. However, a specific receptor for DHEA has not been identified to date. Here, we describe the synthesis of a photoreactive DHEA derivative (Photo-DHEA). In Photo-DHEA, typical c...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.01.009
更新日期:2011-04-01 00:00:00
abstract::2,2,6,6-Tetramethyl piperidine-N-oxyl nitroxyls are known to partition between aqueous and lipid phases, thus serving as probes to study membrane dynamics. The synthesis of a novel steroidal spin label, 3alpha-hydroxycholan-24-yl-(2",2",6",6"-tetramethyl-N-oxyl)p iperidyl butan-1',4'-dioate, containing 2,2,6,6-tetrame...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00072-0
更新日期:1999-12-01 00:00:00
abstract::This study examined the role of protein kinase C enzymatic activity as a physiologic determinant of stromal cell death in decidua basalis (DB) during pregnancy. The expression of epidermal growth factor receptor (EGF-R) and Bcl2 was used as an indicator of stromal cell proliferation/survival, whereas Bax and the occur...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00044-6
更新日期:1999-09-01 00:00:00
abstract::Evaluation of sex steroids in cervical mucus was performed at different phases of spontaneous or clomiphene-citrate-induced ovulatory cycles. To this end, 11 women with normal ovulatory cycles and 9 subjects with polycystic ovary syndrome of comparable age and body mass index were investigated. Serum and cervical mucu...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00074-4
更新日期:2000-01-01 00:00:00
abstract::Male rabbits were infused at a constant rate with 3H-androstenedione/14C-estrone (n = 5) or 3H-testosterone/14C-estradiol-17 beta (n = 3) for 3 1/2 hr and blood samples were obtained over the last hour and analyzed for radioactivity as androstenedione (A), testosterone (T), estrone (E1), estradiol-17 beta (E2 beta) an...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(84)90041-2
更新日期:1984-02-01 00:00:00
abstract::This study describes a new approach using stable isotope methodology in evaluating 11beta-HSD activities in vivo based on urinary excretion of cortisol, cortisone, and their A-ring reduced metabolites. The method involved the measurement of deuterium-labeled cortisol and its deuterium-labeled metabolites by GC/MS simu...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(99)00086-0
更新日期:2000-02-01 00:00:00
abstract::We describe a novel steroid, which we have named "Ionotropin". Its unique features are: [1] it has 23 carbon atoms and [2] it is a phosphocholine ester. There are no other known mammalian steroids with either structural feature. Ionotropin cross reacts with digoxin-specific antibodies and may be the long-sought, endog...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.03.001
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Adiponectin, an insulin-sensitive hormone that is primarily synthesized in adipose tissue, exerts its effects by binding to two receptors, adipoR1 and adipoR2. Little is known regarding the effects of glucocorticoids on the expression of adiponectin receptors. METHODS:Male Wistar rats were bilaterally adren...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.06.004
更新日期:2011-11-01 00:00:00
abstract::The metabolism of tamoxifen is being redefined in the light of several important pharmacological observations. Recent studies have identified 4-hydroxy N-desmethyltamoxifen (endoxifen) as an important metabolite of tamoxifen necessary for antitumor actions. The metabolite is formed through the enzymatic product of CYP...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2007.07.009
更新日期:2007-11-01 00:00:00
abstract::The effect of cortisol and prostaglandin inhibitors on the growth and development of germinating mung bean, Vigna radiata L. Wilzek, cv. Jumbo was investigated. Cortisol, indomethacin, and a mixture of cortisol with aspirin, or benoxaprofen significantly increased radicle length and the number of lateral roots as comp...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(85)90052-2
更新日期:1985-08-01 00:00:00
abstract::Using pregnenolone as a starting material, some 3-substituted 17-[1',2',3']-selenadiazolylpregnenolone derivatives were synthesized, and their structures were characterized by IR, NMR and HRMS. The in vitro antitumor activity of the compounds was assayed against PC-3、SKOV3、T47D、MCF-7 and HEK293T cell lines. The result...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.10.004
更新日期:2018-12-01 00:00:00
abstract::The effect of a substituent in the 12-position of progestagens was studied. To this end, various approaches toward the preparation of 12 beta-alkyl- and 12-alkylidenenorpregnanes were investigated. Eventually, the desired compounds 17 beta-hydroxy-12 beta-methyl-18a-homo-19-nor-17 alpha-pregn-4-en-20-yn-3-one (37) and...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(92)90020-a
更新日期:1992-11-01 00:00:00
abstract::Apoptosis is a highly organized mechanism that allows specific cells to die in a controlled manner. Apoptosis can be induced by a variety of agents in a great number of cell types, but cell shrinkage and discrete chromatin cleavage remain common components of apoptosis that is manifested by constitutive enzymes. Despi...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/s0039-128x(99)00034-3
更新日期:1999-09-01 00:00:00
abstract::Circulating human lymphocytes are known to contain specific glucocorticoid receptors. Using a competitive binding whole cell assay, we have examined the binding of [3H] dexamethasone to peripheral lymphocytes of normal male subjects. Lymphocytes were found to contain 2000-10000 glucocorticoid receptor sites/cell and t...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(86)90098-x
更新日期:1986-04-01 00:00:00
abstract::Evidence showed that the stress hormone corticosterone (CORT) injection resulted in dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis implicated in major depressive disorder. Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of depres...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.03.005
更新日期:2018-07-01 00:00:00
abstract::We have monitored the effect of ergosterol on electrical capacitance and electrical resistance of the phosphatidylcholine bilayer membranes using chronopotentiometry method. The chronopotentiometric characteristic of the bilayers depends on constant-current flow through the membranes. For low current values, no electr...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2011.05.009
更新日期:2011-09-01 00:00:00
abstract::Radioactive mestranol (ME) and/or ethynylestradiol (EE) were administered to women in Nigeria, Sri Lanka, and the USA, and the types and patterns of radioactive urinary conjugates examined by Sephadex LH-20 chromatography. There are no differences in the total excretion of urinary radioactivity over 3 days. Consistent...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(80)90001-x
更新日期:1980-09-01 00:00:00
abstract::A rapid and efficient synthesis of 6E-hydroximinosteroid homodimers is described. The two new compounds were linked at position 3 of the steroid nucleus via a ruthenium catalyzed cross-metathesis reaction. The cytotoxic activity of these compounds was evaluated in vitro on human lung carcinoma A549 (ATCC CCL-185), col...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2007.03.014
更新日期:2007-10-01 00:00:00
abstract::The synthesis of seco-D and D-homo digitalis derivatives, from the carda-14,20(22)-dienolide 1, is described. Selective ozonolysis gave the seco-D 14-ketoaldehyde 2a. Modification of the two carbonyl groups and of the alpha, beta-unsaturated lactone ring of the seco-D 14-ketoaldehyde 2a allowed preparation of derivati...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/s0039-128x(96)00117-1
更新日期:1996-10-01 00:00:00
abstract::Sedentary lifestyle and over-nutrition are the main causes of obesity and type 2 diabetes (T2D). However, the same causes are major triggers of hypogonadism. Many T2D patients show low testosterone levels while hypogonadal men seem to be prone to become diabetic. Testosterone plays a major role in the regulation of mu...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2018.08.002
更新日期:2018-10-01 00:00:00
abstract::Formestane (F, androst-4-en-4-ol-3,17-dione) is an irreversible aromatase inhibitor with the ability to suppress the estrogen production from anabolic steroids. Consequently, F is mentioned on the World Anti-Doping Agency (WADA) prohibited list and because studies have shown that F is produced endogenously in small am...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2013.07.011
更新日期:2013-11-01 00:00:00
abstract::Counterfeiting and adulteration of pharmaceuticals is a prevalent problem worldwide and represents a major health risk to the population, with anabolic steroids being one of the main classes of drugs consumed and obtained from dubious sources. In this work, we propose the use of the 1H NMR technique to evaluate formul...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2018.07.002
更新日期:2018-10-01 00:00:00
abstract::Carbon-13 nuclear magnetic resonance spectra for 31 3 beta-hydroxy and acetoxy androstane derivatives bearing vicinal oxygenated functions at ring D with and without oxygenated functions at C-6 are reported. Relative substituent effects are discussed. ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(91)90077-9
更新日期:1991-04-01 00:00:00
abstract::Testosterone is required for the maturation of male germ cells, the production of sperm and thus male fertility. However, the mechanisms by which testosterone regulates spermatogenic processes have not been well defined. In this review, classical and non-classical pathways of testosterone signaling in the Sertoli cell...
journal_title:Steroids
pub_type: 杂志文章,评审
doi:10.1016/j.steroids.2008.11.017
更新日期:2009-07-01 00:00:00
abstract::Complete analysis of the proton nuclear magnetic resonance spectrum of desoxycorticosterone (DOC) has been made using selective double irradiation, two-dimensional experiments, relaxation rate, and nuclear Overhauser effect measurements in order to specify the structure and conformation of products encountered during ...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/0039-128x(88)90025-6
更新日期:1988-03-01 00:00:00
abstract::Progesterone and its polar metabolite(s) trigger the meiotic divisions in the amphibian oocyte through a non-genomic signaling system at the plasma membrane. Published site-directed mutagenesis studies of ouabain binding and progesterone-ouabain competition studies indicate that progesterone binds to a 23 amino acid e...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2012.04.012
更新日期:2012-09-01 00:00:00
abstract::The chemoselectivity of rigid cyclic alpha,beta-unsaturated carbonyl group on the reducing agents was influenced by the ring size and steric factor. Cholesterol (cholest-5-en-3beta-ol) and dehydroepiandrosterone (DHEA) were oxidized with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone to form 1,4,6-cholestatrien-3-one and 1...
journal_title:Steroids
pub_type: 杂志文章
doi:10.1016/j.steroids.2006.12.008
更新日期:2007-04-01 00:00:00