Abstract：
:The binding activity of four vitamin D metabolites and/or analogs for the intestinal 1,25-dihydroxyvitamin D3 receptor was evaluated after incubation at 25 degrees C for 1 h or at 0-4 degrees C for 18 h. The incubation conditions, which had no effect on the binding of 1,25-dihydroxyvitamin D3, had a dramatic effect on the binding of 25-hydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3 and a small but reproducible effect on 24,25-dihydroxyvitamin D3 binding to receptor. Affinities 10- to 20-fold higher were obtained for 25-hydroxyvitamin D3 and 1 alpha-hydroxyvitamin D3, and affinities 3-fold higher were obtained for 24,25-dihydroxyvitamin D3 at the 0-4 degrees C/18-h incubation. A comparison of intestinal receptor from chick and pig with nine vitamin D compounds showed no major differences between the two species. The relative affinity of the vitamin D analogs to compete with tritiated 1,25-dihydroxyvitamin D3 for the receptor in pig nuclear extract, expressed as ratios of the molar concentration required for 50% binding of the tritiated 1,25-dihydroxyvitamin D3 compared to nonradioactive 1,25-dihydroxyvitamin D3, are as follows: 1,25-dihydroxyvitamin D3 (1) = 1,25-dihydroxyvitamin D2 = 24-homo-1,25-dihydroxyvitamin D3 greater than 1,24,25-trihydroxyvitamin D3 (4) greater than 25-hydroxyvitamin D3 (21) = 10-oxo-19-nor-25-hydroxyvitamin D3 = 1 alpha-hydroxyvitamin D3 (37) greater than 24,25-dihydroxyvitamin D2 (257) much much greater than vitamin D3 (greater than 10(6)).
journal_name
Steroidsjournal_title
Steroidsauthors
Link RP,DeLuca HFdoi
10.1016/0039-128x(88)90054-2subject
Has Abstractpub_date
1988-05-01 00:00:00pages
583-98issue
5-6eissn
0039-128Xissn
1878-5867pii
0039-128X(88)90054-2journal_volume
51pub_type
杂志文章相关文献
STEROIDS文献大全abstract：:A phytochemical study of Physalis pubescens L. afforded twelve compounds, including six new withanolides (1, 4, and 6i-9), four new withanolide glucosides (2, 3, 5, and 6), and two known withanolides (10 and 11). Their structures were established via extensive spectroscopic analysis. The absolute configuration of 3 wa...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2016.09.002
更新日期：2016-11-01 00:00:00
abstract：:In our effort to develop imaging agents for brain glucocorticoid receptors, we have prepared several novel glucocorticoids possessing a 2-methylsulfanyl-acetyl side chain. The synthesis was accomplished via a Mitsunobu reaction with thiobenzoic acid starting from cortisol, prednisolone, dexamethasone and triamcinolone...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2007.08.013
更新日期：2008-01-01 00:00:00
abstract：:7 beta-Methyl-chenodeoxycholic acid (7-MeCDC, 3 alpha, 7 alpha-dihydroxy-7 beta-methyl-5 beta-cholan-24-oic acid), 7 alpha-methyl-ursodeoxycholic acid (7-MeUDC, 3 alpha, 7 beta-dihydroxy-7 alpha-methyl-5 beta-cholan-24-oic acid), 7 xi-methyl-lithocholic acid (7-MeLC, 3 alpha-hydroxy-7 xi-methyl-5 beta-cholan-24-oic ac...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(84)80025-2
更新日期：1984-10-01 00:00:00
abstract：:Ischemic heart disease (IHD) continues to be the most common cause of death globally, although mortality rates are decreasing with significant advances in treatment. Higher prevalence of co-morbidities in women only partly explains the lack of decrease in mortality rates in younger women due to. Until recently there h...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2014.08.013
更新日期：2014-12-01 00:00:00
abstract：:Over the past 30 years, numerous studies in invertebrates and vertebrates have established a role of calcium in oocyte maturation as well as in the resumption and progression of follicular development. Polycystic ovarian syndrome (PCO) is characterized by hyperandrogenic chronic anovulation, theca cell hyperplasia, an...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(99)00012-4
更新日期：1999-06-01 00:00:00
abstract：:During the periparturient period, dairy cows are subjected to physiological changes that may induce immunosuppression and an increased susceptibility of the animal to bacterial infections such as mastitis. The incidence of clinical environmental mastitis is high during the last period of gestation, at parturition and ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(03)00040-0
更新日期：2003-05-01 00:00:00
abstract：:5 alpha-(17R,20R)-14,15-Secocholestane (12) was synthesized from cholesterol (1) in 12 steps. The key intermediate, 5 alpha-cholest-14-en-3 beta-yl acetate (4), underwent ozonization, reduction, hydrolysis, and oxidation to provide 5 alpha-14,15-secocholesta-3,14,15-trione (8). One of the Clemmensen reduction products...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(90)90042-a
更新日期：1990-06-01 00:00:00
abstract：:An homogenate from cortical tissue of mare adrenals was incubated in the presence of tritiated pregnenolone. The (3H) androstenedione and the (3H) testosterone synthesized during the incubation were extracted, purified, and co-crystallized to constant specific activity in the presence of unlabeled carriers. The rate o...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(84)90033-3
更新日期：1984-02-01 00:00:00
abstract：:Bile acid salts are biosurfactants which form mixed micelles with phospholipids in vertebrates. These mixed micelles are suitable for solubilisation of cholesterol. For therapeutic purposes some bile acid salts as sodium ursocholate are used. However, bile acid anions possess low capacity for solubilisation of cholest...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2014.04.018
更新日期：2014-08-01 00:00:00
abstract：:Formestane (F, androst-4-en-4-ol-3,17-dione) is an irreversible aromatase inhibitor with the ability to suppress the estrogen production from anabolic steroids. Consequently, F is mentioned on the World Anti-Doping Agency (WADA) prohibited list and because studies have shown that F is produced endogenously in small am...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.07.011
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:Once a septic condition is progressing, administration of steroids in the pro-inflammatory phase of septic shock ought to yield maximal effect on the subsequent, devastating inflammatory response. Recently, a retrospective study showed that early initiation of corticosteroid therapy improved survival in sept...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.06.001
更新日期：2012-09-01 00:00:00
abstract：:Because diffusion of testosterone (T) into the salivary gland is thought to be largely limited to the free, biologically active fraction, salivary testosterone is expected to provide a better measure of testosterone bioavailability in the body than is plasma testosterone. Matched saliva and blood spot samples were col...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(96)00043-8
更新日期：1996-06-01 00:00:00
abstract：:Four new pregnane glycosides, stelmatocryptonoside A, B, C, and D (1-4), were isolated from the stems of Stelmatocrypton khasianum. On the basis of chemical and spectral data, the structures of 1-4 were established as 3beta, 16alpha-dihydroxy-pregn-5-en-20-one-16-O-beta-D-glucopyranosyl-(1-->2)-[beta-D-glucopyranosyl-...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(01)00187-8
更新日期：2002-04-01 00:00:00
abstract：:Synthesis, biochemical and biological testing of the first carborane derivatives of estrogens are described. Estrone 3-carboranylmethyl ether was synthesized in two steps from estrone. Reduction of estrone 3-carboranylmethyl ether with sodium borohydride provided estradiol-17 beta 3-carboranylmethyl ether. Enzyme kine...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(81)80020-7
更新日期：1981-02-01 00:00:00
abstract：:Three new polyhydroxysterols, named muriflasteroids A-C (1-3) were isolated from the South China Sea gorgonian Muriceopsis flavida, together with sixteen known analogs, cholest-3β,5α,6β-triol,3β-acetate (4), 5α-methoxycholest-3β,6β-diol (5), (22E)-cholest-22-en-3β,5α,6β-triol (6), cholest-3β,5α,6β-triol (7), (22E)-24-...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2012.10.003
更新日期：2013-01-01 00:00:00
abstract：:The role played by progestogens in modulating Schwann cell pathophysiology is well established. Progestogens exert their effects in these cells through both classical genomic and non-genomic mechanisms, the latter mediated by the GABA-A receptor. However, there is evidence that other receptors may be involved. Membran...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2017.09.009
更新日期：2019-02-01 00:00:00
abstract：:A new spirostane steroidal saponin, govanoside A (1) along with three known compounds borassoside E (2) pennogenin (3) and diosgenin (4) were isolated from rhizomes of Trillium govanianum. Their structures were elucidated through 1D, 2D-NMR spectroscopic data analysis and acid hydrolysis. Compound (2) in genus Trilliu...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2015.10.013
更新日期：2015-12-01 00:00:00
abstract：:Initial excretion studies with orally administered [monoethyl-1-3H] DES demonstrated the feces to be the principal mode of elimination of DES in the C3H mouse. Metabolic studies with tritiated DES and/or [UL-14C] DES were performed with orally dosed C3H high (MTV+) and low (MTV-) titer MMTV female mice. Extraction and...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(78)90029-6
更新日期：1978-04-01 00:00:00
abstract：:The main purpose of this review article is threefold (a) to try to address the question "why are two adrenal glucocorticoids, cortisol and corticosterone, secreted by humans and other mammalian species?", (b) to outline a hypothesis that under certain physiological conditions, corticosterone has additional biochemical...
journal_title：Steroids
pub_type： 杂志文章,评审
doi：10.1016/j.steroids.2015.06.017
更新日期：2015-10-01 00:00:00
abstract：:Although exogenous glucocorticoids (GC) play a role in the regulation of bone marrow mesenchymal stem/stromal cells (MSCs) proliferation and differentiation, the function of endogenous GC is not well understood. The purpose of this study was to investigate the effect of the blockage of endogenous GC using RU486, an an...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.10.017
更新日期：2012-01-01 00:00:00
abstract：:A short and efficient synthesis of steroid synthons, di(tert-butyldimethylsilyl) ethers of 3,21-dihydroxy-24-nor-chol-5-en-23-al (8 and 10) and of ethyl 3,21-dihydroxy-25-homo-chola-5,23-dien-25-oate (9 and 11), having natural (20R) and unnatural (20S) configuration from 3β-(tert-butyldimethylsilyloxy)-14α,20ξ-card-5-...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.01.010
更新日期：2011-04-01 00:00:00
abstract：:A new synthetic pathway towards secosteroidal macrocycles was described via a reaction of cycloaddition as the key step. The characteristic (1)H and (13)C NMR spectroscopic features of the synthesized compounds are reported. ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.12.002
更新日期：2014-02-01 00:00:00
abstract：:By the conventional methods of gas liquid chromatography (GLC) as well as mass spectrometry, 3beta,7alpha-dihydroxychol-5-en-24-oic acid (delta5-acid), a key intermediate of chenodeoxycholic acid biogenesis and its metabolic by-product, 3alpha,7alpha-dihydroxychol-4-en-24-oic acid (delta4-acid) have not yet been ident...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(78)90102-2
更新日期：1978-07-01 00:00:00
abstract：:The therapeutic use of progesterone following traumatic brain injury has recently entered phase III clinical trials as a means of neuroprotection. Although it has been hypothesized that progesterone protects against calcium overload following excitotoxic shock, the exact mechanisms underlying the beneficial effects of...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2011.02.013
更新日期：2011-08-01 00:00:00
abstract：:Enzyme immunoassays (EIA) are commonly utilized for the evaluation of androgens in biological fluids; however, careful consideration must be given to cross-reactivity with other endogenous sex-steroid hormones. Our purpose was to determine the validity of a commonly-utilized commercially-available dihydrotestosterone ...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.08.013
更新日期：2013-12-11 00:00:00
abstract：:The synthesis of 6alpha- and 6beta-testosterone-bovine serum albumin (BSA) conjugates is described. 6beta-Carboxymethyl-4-androstene-3,17-dione was prepared by a route analogous to that described earlier for 6beta-carboxymethyl progesterone. Sodium borohydride reduction of the 3 and 17 keto groups and subsequent selec...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/s0039-128x(75)80004-3
更新日期：1975-01-01 00:00:00
abstract：:Ten new 9,11-secosteroids, subergorgols A-J (1-10), including two pairs of epimers (3/4, and 6/7), along with three known analogues (11-13) were isolated from the South China Sea gorgonian Subergorgia suberosa. The structures of these compounds were elucidated on the basis of extensive spectroscopic analyses and compa...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2013.05.009
更新日期：2013-09-01 00:00:00
abstract：:Readily available vanadyl acetylacetonate was found to oxidize the allylic sites of Δ(5) steroidal alcohols without protection of hydroxyl groups. Cholesterol, dehydroepiandrosterone, cholesterol benzoate, cholesterol acetate, pregnenolone, and 5-pregnen-3,20-diene were oxidized to 7-keto products using vanadyl acetyl...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2015.06.005
更新日期：2015-09-01 00:00:00
abstract：:Smith-Lemli-Opitz syndrome (SLOS) is caused by deficiency in the terminal step of cholesterol biosynthesis, which is catalyzed by 7-dehydrocholesterol reductase (DHCR7). The disorder exhibits several phenotypic traits including dysmorphia and mental retardation with a broad range of severity. Pathogenesis of SLOS is c...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/j.steroids.2007.07.002
更新日期：2007-10-01 00:00:00
abstract：:The mass spectral elimination of water in epimeric 1,3-diols of vitamin D3 (colecalciferol) series has been investigated. It was found that the mass spectra of these steroisomers differ sharply in the relative intensities of the ions M-H2O (m/e 382) and a-H2O (m/e +/- 34), where ion a (formed via formal cleavage of th...
journal_title：Steroids
pub_type： 杂志文章
doi：10.1016/0039-128x(79)90039-4
更新日期：1979-05-01 00:00:00
