Abstract：
:The non-genomic action of steroid hormones regulates a wide variety of cellular responses including regulation of ion transport, cell proliferation, migration, death and differentiation. In order to achieve such plethora of effects steroid hormones utilize nearly all known signal transduction pathways. One of the key signalling molecules regulating the non-genomic action of steroid hormones is protein kinase C (PKC). It is thought that rapid action of steroids hormones results from the activation of plasma membrane receptors; however, their molecular identity remains elusive. In recent years, an increasing number of studies have pointed at the selective binding and activation of specific PKC isoforms by steroid hormones. This has led to the hypothesis that PKC could act as a receptor as well as a transducer of the non-genomic effects of these hormones. In this review we summarize the current knowledge of the direct binding and activation of PKC by steroid hormones.
journal_name
Steroidsjournal_title
Steroidsauthors
Alzamora R,Harvey BJdoi
10.1016/j.steroids.2008.01.001subject
Has Abstractpub_date
2008-10-01 00:00:00pages
885-8issue
9-10eissn
0039-128Xissn
1878-5867pii
S0039-128X(08)00013-5journal_volume
73pub_type
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