Abstract:
:Plasma concentration measurements of 13C-labeled cortisol ([1,2,4,19-13C(4)]cortisol, cortisol-13C(4)) and its metabolite cortisone-13C(4) were made simultaneously with measurements of endogenous cortisol and cortisone by gas chromatography-mass spectrometry (GC-MS). After administering a small amount (3mg) of cortisol-13C(4) to a human subject, changes in cortisol secretion rates were estimated by deconvolution techniques from the measured plasma cortisol and cortisone levels and the rates of elimination and interconversion of cortisol and cortisone were obtained from the plasma concentration-time data of cortisol-13C(4) and cortisone-13C(4). The objective of this study was to look for a novel approach to quantitate rates of minute-to-minute cortisol secretion in man by taking into account the interconversion of cortisol and cortisone by 11beta-hydroxysteroid dehydrogenase (11beta-HSD).
journal_name
Steroidsjournal_title
Steroidsauthors
Kasuya Y,Yokokawa A,Shibasaki H,Furuta Tdoi
10.1016/s0039-128x(02)00037-5subject
Has Abstractpub_date
2002-08-01 00:00:00pages
783-8issue
9eissn
0039-128Xissn
1878-5867pii
S0039128X02000375journal_volume
67pub_type
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