Abstract:
:The four diastereomeric 3,16-diacetates 6, 9, 10 and 11 were prepared from gitoxin 1 by the routes shown in Schemes 1 and 2 and tested for inotropic activity in the isolated guinea-pig atrial preparation. In line with earlier findings in the digitoxigenin series, derivatives with a 3 alpha-acetoxy function, viz 9 and 10, possessed high biological activity.
journal_name
Steroidsjournal_title
Steroidsauthors
Humber DC,Jones PS,Phillipps GHdoi
10.1016/0039-128x(85)90062-5subject
Has Abstractpub_date
1985-01-01 00:00:00pages
19-30issue
1eissn
0039-128Xissn
1878-5867pii
0039-128X(85)90062-5journal_volume
45pub_type
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