Abstract:
:Testicular homogenates of tamoxifen-treated rats were incubated with labeled steroid precursors (progesterone, 17 alpha-hydroxyprogesterone, dehydroepiandrosterone, androstenedione or testosterone) in order to study the effect of tamoxifen on testicular steroidogenesis. The results indicate that a 9 day treatment with a daily dose of 1 mg tamoxifen produces a reduction of the synthesis of testosterone. Inhibition of the 17 alpha-hydroxylase and C17,20-desmolase enzyme systems was observed together with an increased 20 alpha-hydroxysteroid dehydrogenase activity.
journal_name
Steroidsjournal_title
Steroidsauthors
Vanderstichele H,Eechaute W,Lacroix E,Leusen Idoi
10.1016/0039-128x(89)90062-7subject
Has Abstractpub_date
1989-06-01 00:00:00pages
713-26issue
6eissn
0039-128Xissn
1878-5867pii
0039-128X(89)90062-7journal_volume
53pub_type
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