Abstract:
:Estrogen receptor (ER) positive primary breast cancers have a wide range of clinical outcomes. Prediction of the likely course of the disease aids treatment decision-making. In the translational arm of the ATAC (anastrozole or tamoxifen alone or combined) trial (TransATAC) we have assessed individual and multiparameter biomarkers for their prediction of overall and distant recurrence. None of the biomarkers identified differential benefit for anastrozole versus tamoxifen. Each of ER, PgR, HER2 and Ki67 was associated with risk of recurrence. A combination of these to create a single predictor IHC4 was as informative as the 21-gene recurrence score (RS). Integration of each of these molecular profiles with classical clinicopathologic variables provided the most accurate prediction of outcome.
journal_name
Steroidsjournal_title
Steroidsauthors
Dowsett M,Salter J,Zabaglo L,Mallon E,Howell A,Buzdar AU,Forbes J,Pineda S,Cuzick Jdoi
10.1016/j.steroids.2011.02.032subject
Has Abstractpub_date
2011-07-01 00:00:00pages
777-80issue
8eissn
0039-128Xissn
1878-5867pii
S0039-128X(11)00072-9journal_volume
76pub_type
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