A convenient strategy for the annulation of aryl scaffold to A/B-ring steroids under microwave irradiation.

abstract：:The isoflavonoids, genistein (4',5,7-trihydroxyisoflavone), biochanin A (5,7-dihydroxy-4'-methoxyisoflavone), daidzein (4',7-dihydroxyisoflavone), and formononetin (7-hydroxy-4'-methoxyisoflavone) are supposed to be health-promoting dietary factors of plant origin. They are particularly abundant in seeds and other par...

journal_title：Steroids

authors： Lapcík O,Hill M,Hampl R,Wähälä K,Adlercreutz H

更新日期：1998-01-01 00:00:00

abstract：:Lung cancer is the most common cause of cancer mortality in male and female patients in the US. The etiology of non-small cell lung cancer (NSCLC) is not fully defined, but new data suggest that estrogens and growth factors promote tumor progression. In this work, we confirm that estrogen receptors (ER), both ERalpha ...

journal_title：Steroids

authors： Márquez-Garbán DC,Chen HW,Fishbein MC,Goodglick L,Pietras RJ

更新日期：2007-02-01 00:00:00

abstract：:Using 1 alpha,2 alpha-oxido-cholesta-5,7-diene-3 beta,25-diol (2) as a starting material, the provitamins of calcitriol with an additional 2 beta-chloro-, 2 beta-fluoro-, and 2 beta-methoxy-substituent (3,4,5) are obtained by transdiaxial opening of the oxirane ring with nucleophiles. An efficient irradiation process ...

journal_title：Steroids

authors： Scheddin D,Mayer H,Schönecker B,Gliesing S,Reichenbächer M

更新日期：1998-12-01 00:00:00

abstract：:Determinations of oxygen solubility in serum were made utilizing various concentrations of corticosteroids in the serum. Within a certain concentration range dexamethasone and betamethasone caused an increase in oxygen solubility. None of the other steroids tested demonstrated this property. ...

journal_title：Steroids

authors： Gainer JL,Kelly R

更新日期：1976-09-01 00:00:00

abstract：:The reduction of 17-oxosteroids to 17β-hydroxysteroids is one of the important transformations for the preparation of many steroidal drugs and intermediates. The strain Zygowilliopsis sp. WY7905 was found to catalyze the reduction of C-17 carbonyl group of androst-4-ene-3,17-dione (AD) to give testosterone (TS) as the...

journal_title：Steroids

authors： Liu Y,Wang Y,Chen X,Wu Q,Wang M,Zhu D,Ma Y

更新日期：2017-02-01 00:00:00

abstract：:A novel steroid, 1alpha,3beta,5beta-trihydroxy-24-methylenecholestan-6-one (gibberoketosterol) (1), along with four known steroids, was isolated from the lipophilic extracts of a Taiwanese soft coral Sinularia gibberosa. The structure of the new metabolite was determined on the basis of extensive spectral analyses and...

journal_title：Steroids

authors： Ahmed AF,Dai CF,Kuo YH,Sheu JH

更新日期：2003-04-01 00:00:00

abstract：:In this study, we assessed the rate of estradiol degradation via the 17 beta-hydroxysteroid dehydrogenase (HSD) enzyme in breast tumors from postmenopausal women. We initially studied the effects of time, level of enzyme activity, amount of tissue assayed, and substrate concentration on the linearity of conversion of ...

journal_title：Steroids

authors： Leszczynski D,Santner SJ,Feil PD,Santen RJ

更新日期：1988-03-01 00:00:00

abstract：:In the present study, synthesis and antineoplastic activity of phenylacetic acid and benzoic acid nitrogen mustard conjugates of various steroidal oximes are reported for the first time. The conjugation was achieved through a more stable oxime-ester linkage and the resulting newly synthesized conjugates were evaluated...

journal_title：Steroids

authors： Acharya PC,Bansal R

更新日期：2017-07-01 00:00:00

abstract：:26,26,26,27,27,27-Hexafluo-1,25(OH)2 vitamin D3, the hexafluorinated analog of 1,25(OH)2 vitamin D3, has been reported to be several times more potent than the parent compound regarding some vitamin D actions. The reason for enhanced biologic activity in the kidneys and small intestine appears to be related to F6-1,25...

journal_title：Steroids

authors： Komuro S,Kanamaru H,Nakatsuka I,Yoshitake A

更新日期：1998-10-01 00:00:00

abstract：:Plasma concentrations of dehydroepiandrosterone (DHEA), 5-androstene-3beta,17beta-diol (AED), and 17beta-estradiol (E2) in dairy cows and heifers and AED binding to uterine cytosolic estrogen receptor (ER) were studied. Plasma samples were collected from the subcutaneous abdominal (SA) and jugular (J) veins of heifers...

journal_title：Steroids

authors： Gabai G,Marinelli L,Simontacchi C,Bono GG

更新日期：2004-02-01 00:00:00

abstract：INTRODUCTION:ERα36 is a recently cloned variant of estrogen receptor-alpha which has been proved to play an active role in a series of malignant diseases. METHOD:ERα36 expression was examined using immunohistochemical methods with sections from 126 resected NSCLC specimens. The immunoreactivity of ERα66 was also studi...

journal_title：Steroids

authors： Zhang S,Qiu C,Wang L,Liu Q,Du J

更新日期：2014-09-01 00:00:00

abstract：:The Na-K-2Cl cotransporter (NKCC2) regulates sodium transport along the thick ascending limb of Henle's loop and is important in control of sodium balance, renal concentrating ability and renin release. To determine if there are sex differences in NKCC2 abundance and/or distribution, and to evaluate the contribution o...

journal_title：Steroids

authors： Musselman TM,Zhang Z,Masilamani SM

更新日期：2010-11-01 00:00:00

abstract：:Biologic sex and sex steroids are important factors in clinical and experimental stroke. This review evaluates key evidence that biological sex strongly alters mechanisms and outcomes from cerebral ischemia. The role of androgens in male stroke is understudied and important to pursue given that male sex is a well know...

journal_title：Steroids

authors： Cheng J,Hurn PD

更新日期：2010-11-01 00:00:00

abstract：:Sertoli cells isolated from 17 day old rats were maintained in culture and incubated with [14C]-progesterone for 20 h. The cells and media were extracted with ether/chloroform and the extracts chromatographed two-dimensionally on TLC and the radioactive metabolites visualized by autoradiography. Nine of the metabolite...

journal_title：Steroids

authors： Wiebe JP,Tilbe KS,Buckingham KD

更新日期：1980-05-01 00:00:00

abstract：:4- to 8-cell mouse PIE's (preimplantation embryos) were cultured in vitro for 48 hr in media containing various concentrations of the anti-estrogen CI-628. Graded effects of the various concentrations were observed with the highest concentration (1.5 microng/ml) being 100% effective in blocking development to the blas...

journal_title：Steroids

authors： Gupta JS,Dey SK,Dickmann Z

更新日期：1977-03-01 00:00:00

abstract：:In comparison with the glucocorticoids cortisol and corticosterone, the mineralocorticoid aldosterone is a minority hormone of the mammalian adrenal cortex, and its proper function is dependent upon protective physiological mechanisms. These include a particular site of aldosterone synthesis in zona glomerulosa cells ...

journal_title：Steroids

authors： Müller J

更新日期：1995-01-01 00:00:00

abstract：:Two new sterols, (24E)-24-n-propylidenecholesterol and 24 epsilon-n-propylcholesterol, were isolated from a cultured marine Chrysophyte. Since most of the steroids found in marine invertebrates are unchanged or modified sterols of algal or symbiotic origin, the discovery of these two unusual sterols in a unicellular a...

journal_title：Steroids

authors： Rohmer M,Kokke WC,Fenical W,Djerassi C

更新日期：1980-02-01 00:00:00

abstract：:A radioimmunoassay of three deoxycorticoids, namely 11 beta,17 alpha-dihydroxy-4-pregnene-3,20-dione (21-deoxycortisol), 17 alpha,21-dihydroxy-4-pregnene-3,20-dione (11-deoxycortisol), and 21-hydroxy-4-pregnene-3,20-dione (11-deoxycorticosterone) which are important for differential diagnosis of congenital adrenal dis...

journal_title：Steroids

authors： Hill M,Lapcík O,Hampl R,Stárka L,Putz Z

更新日期：1995-09-01 00:00:00

abstract：:The aim of the present work was to analyze the effect of dehydroepiandrosterone (DHEA) on several metabolic risk factors, including cardiovascular health and insulin resistance, in aged rats submitted to a high-fat diet. For that, weaned rats were fed on a high-fat diet until 20 months of age. In the last 13 weeks of ...

journal_title：Steroids

authors： Pérez-de-Heredia F,Sánchez J,Priego T,Nicolás F,Portillo Mdel P,Palou A,Zamora S,Garaulet M

更新日期：2008-10-01 00:00:00

abstract：:The aim of the study was to evaluate the relationship between phytosterols, oxyphytosterols, and other markers of cholesterol metabolism and concomitant coronary artery disease (CAD) in patients with severe aortic stenosis who were scheduled for elective aortic valve replacement. Markers of cholesterol metabolism (pla...

journal_title：Steroids

authors： Luister A,Schött HF,Husche C,Schäfers HJ,Böhm M,Plat J,Gräber S,Lütjohann D,Laufs U,Weingärtner O

更新日期：2015-07-01 00:00:00

abstract：:A method for the synthesis and purification of 6beta-iodomethyl-19-norcholest-5(10)-ene-3beta-ol-131I of greater than 98 mole% chemical purity and greater than 99% radiochemical purity is presented. Carbon-13 and proton NMR were used to establish the identity and purity. Discrepancies in the characterization of this c...

journal_title：Steroids

authors： Scott KN,Couch MW,Mareci TH,Williams CM

更新日期：1976-08-01 00:00:00

abstract：:Preimplantation rabbit embryos were incubated with pregnenolone and dehydroisoandrosterone under conditions which gave formazan precipitation by the histochemical technique. The metabolic fate of the labeled steroids was assessed simultaneously. There was no concomitant transformation of pregnenolone to progesterone a...

journal_title：Steroids

authors： Bleau G

更新日期：1981-02-01 00:00:00

abstract：:In our effort to develop imaging agents for brain glucocorticoid receptors, we have prepared several novel glucocorticoids possessing a 2-methylsulfanyl-acetyl side chain. The synthesis was accomplished via a Mitsunobu reaction with thiobenzoic acid starting from cortisol, prednisolone, dexamethasone and triamcinolone...

journal_title：Steroids

authors： Wuest F,Carlson KE,Katzenellenbogen JA

更新日期：2008-01-01 00:00:00

abstract：:Bile acid salts are biosurfactants which form mixed micelles with phospholipids in vertebrates. These mixed micelles are suitable for solubilisation of cholesterol. For therapeutic purposes some bile acid salts as sodium ursocholate are used. However, bile acid anions possess low capacity for solubilisation of cholest...

journal_title：Steroids

authors： Poša M,Bjedov S,Sebenji A,Sakač M

更新日期：2014-08-01 00:00:00

abstract：:The steroid receptor-positive human ovarian cancer (BG-1) was evaluated to determine its usefulness as a tumor model. This tumor grows in intact male and female nude mice without hormone supplements. Moreover, its growth was significantly accelerated in ovariectomized mice, and the increased growth rate could be rever...

journal_title：Steroids

authors： Zimniski SJ,Garola RE,Fendl K,Peterson CM

更新日期：1989-12-01 00:00:00

abstract：:The free sterol mixture of the sponge Psammaplysilla purpurea was shown to contain aplysterol as the major constituent. In addition to other sterols such as 5,7-cholestadien-3beta-ol, cholesterol, 5alpha-cholestan-3beta-ol, 24epsilon-methylcholesta-5,22-dien-3beta-ol, 24epsilon--methylcholesterol, 24epsilon-ethylchole...

journal_title：Steroids

authors： Ayanoglu E,Djerassi C,Erdman TR,Scheuer PJ

更新日期：1978-06-01 00:00:00

abstract：:The steroid nucleus is an interesting scaffold for the development of new therapeutic agents. Within the goal of identifying anticancer agents, new pregnane derivatives were prepared by using a sequence of liquid and solid-phase reactions. After we dehydrated epi-allopregnanolone in one step with diethylaminosulfur tr...

journal_title：Steroids

authors： Jegham H,Maltais R,Dufour P,Roy J,Poirier D

更新日期：2012-11-01 00:00:00

abstract：:Metandienone is one of the most frequently detected anabolic androgenic steroids in sports drug testing. Metandienone misuse is commonly detected by monitoring different metabolites excreted free or conjugated with glucuronic acid using gas chromatography mass spectrometry (GC-MS) and liquid chromatography tandem mass...

journal_title：Steroids

authors： Gómez C,Pozo OJ,Garrostas L,Segura J,Ventura R

更新日期：2013-12-11 00:00:00

abstract：:Biotransformation of danazol (1) (17β-hydroxy-17α-pregna-2,4-dien-20-yno-[2,3-d]-isoxazole) with Cunninghamella blakesleeana yielded three new metabolites 2-4 and a known metabolite 5. These metabolites were identified as 14β,17β-dihydroxy-2-(hydroxymethyl)-17α-pregn-4-en-20-yn-3-one (2), 1α,17β-dihydroxy-17α-pregna-2...

journal_title：Steroids

authors： Baydoun E,Atia-tul-Wahab,Mehmood H,Ahmad MS,Malik R,Smith C,Choudhary MI

更新日期：2016-01-01 00:00:00

abstract：:Ru(II) steroidal metal complexes were synthesized by the reaction of dichlorodicarbonyl ruthenium(II) [Ru(CO)2Cl2]n with Steroidal thiosemicarbazones. Coordination via the thionic sulfur and the azomethine nitrogen atom of the thiosemicarbazone to the Ru(II) metal. Steroidal thiosemicarbazone derivatives were obtained...

journal_title：Steroids

authors： Khan SA,Asiri AM

更新日期：2017-08-01 00:00:00