Abstract:
:The inhibition of testosterone 5alpha-reductase activity by 3-oxo-4-androstene-17beta-carboxylic acid in the male reproductive organs of the rat was demonstrated in vitro. The medium for incubation of caput epididymis showed the highest concentration of 5alpha-dihydrotestosterone (5alpha-DHT) whereas the highest concentration of testosterone (T) was recorded in medium for incubation of decapsulated testis after two hours of incubation. The 3-oxo-4-androstene-17beta-carboxylic acid (1.58 X 10(-5)M) inhibited the conversion of T to 5alpha-DHT in all the organs tested (testis, caput and cauda epididymis and ventral prostate) under identical incubation conditions.
journal_name
Steroidsjournal_title
Steroidsauthors
Saksena SK,Lau IF,Chang MCdoi
10.1016/0039-128x(76)90135-5subject
Has Abstractpub_date
1976-06-01 00:00:00pages
751-7issue
6eissn
0039-128Xissn
1878-5867pii
0039-128X(76)90135-5journal_volume
27pub_type
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