Isoliquiritigenin inhibits cell proliferation and induces apoptosis in human hepatoma cells.

Abstract:

:Isoliquiritigenin (4,2',4'-trihydroxychalcone, ISL) is a natural pigment with a simple chalcone structure. In this study, we report the ISL-induced inhibition on the growth of human hepatoma cells (Hep G2) for the first time. The cell growth inhibition achieved by ISL treatment resulted in programmed cell death in a caspase activation-dependent manner, with an IC50 of 10.51 microg/mL. Outcomes of ISL treatment included the up-regulation of IkappaBalpha expression in the cytoplasm, and the decrease of NF-kappaB level as well as its activity in the nucleus. In addition, ISL also suppressed the expression of Bcl-XL and c-IAP1/2 protein, the downstream target molecule of NF-kappaB. These results demonstrated that ISL treatment inhibited the NF-kappaB cell survival-signaling pathway and induced apoptotic cell death in Hep G2 cells.

journal_name

Planta Med

journal_title

Planta medica

authors

Hsu YL,Kuo PL,Lin LT,Lin CC

doi

10.1055/s-2005-837779

subject

Has Abstract

pub_date

2005-02-01 00:00:00

pages

130-4

issue

2

eissn

0032-0943

issn

1439-0221

journal_volume

71

pub_type

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