Abstract:
:According to traditional usage, the extract of Longan Arillus was tested for its anxiolytic-like effect by application of the Vogel-type anti-conflict method in mice. The extract indicated significant activity at a dose of 2 g/kg, s.c., and results of the bioassay-oriented isolation revealed adenosine to be the active principle. Adenosine produced the anti-conflict effect significantly at a dose of 30 mg/kg, s.c. Adenine, uridine, and 5-methyluridine did not exhibit the effect, although these compounds were isolated from the extract. Some other related compounds such as AMP and c-AMP showed no effect, except for inosine. Adenosine also contributed to the analgesic effect which was observed in the extract by the writhing method.
journal_name
Planta Medjournal_title
Planta medicaauthors
Okuyama E,Ebihara H,Takeuchi H,Yamazaki Mdoi
10.1055/s-1999-14055subject
Has Abstractpub_date
1999-03-01 00:00:00pages
115-9issue
2eissn
0032-0943issn
1439-0221journal_volume
65pub_type
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