Labdane diterpenoids and shikimic acid derivatives from Araucaria cunninghamii.

Abstract:

:Four new (1-4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ENT-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ENT-19-( E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid N-butyl ester (3), and 5-(Z)-coumaroyloxyquinic acid N-butyl ester (4). Compounds 1 and 6 exhibited inhibitory activity against Escherichia coli, and compound 1 also exhibited moderate activity against human leukemia cells (HL-60) and human hepatoma cells (SMMC-7721) with IC₅₀ values of 8.90 and 11.53 µM, respectively.

journal_name

Planta Med

journal_title

Planta medica

authors

Chen J,Chen JJ,Yang LQ,Hua L,Gao K

doi

10.1055/s-0030-1250570

subject

Has Abstract

pub_date

2011-03-01 00:00:00

pages

485-8

issue

5

eissn

0032-0943

issn

1439-0221

journal_volume

77

pub_type

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