[New cardioactive drugs II, detection and isolation of cardiotonic amines with ionpair-HPLC].

Abstract:

:An ionpair-HPLC-technic using a reversed-phase column was developed to screen plant extracts for cardiotonic amines and to isolate them in a preparative scale for direct MS and pharmacological investigations. By this method the positive inotropic tyramine could be isolated from Selenicereus grandiflorus (L.) Britt et Rose (Cactus grandiflorus).

journal_name

Planta Med

journal_title

Planta medica

authors

Wagner H,Grevel J

doi

10.1055/s-2007-971397

subject

Has Abstract

pub_date

1982-01-01 00:00:00

pages

36-40

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

44

pub_type

杂志文章
  • Antifungal activity from Alpinia galanga and the competition for incorporation of unsaturated fatty acids in cell growth.

    abstract::An antimicrobial diterpene was isolated from Alpinia galanga in the screening for potentiators of phytochemical antibiotic action. The structure was elucidated by spectral data and identified as (E)-8 beta, 17-epoxylabd-12-ene-15, 16-dial (1). Diterpene 1 synergistically enhanced the antifungal activity of quercetin a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957890

    authors: Haraguchi H,Kuwata Y,Inada K,Shingu K,Miyahara K,Nagao M,Yagi A

    更新日期:1996-08-01 00:00:00

  • An arabinogalactan-protein from cell culture of Malva sylvestris.

    abstract::An arabinogalactan-protein (AGP) from suspension culture medium of Malva sylvestris was isolated by precipitation with beta-glucosyl Yariv reagent, followed by gel-permeation chromatography. It revealed characteristic features of AGPs: a high amount of polysaccharide with a ratio of galactose to arabinose of 1.9 : 1, ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2002-23127

    authors: Classen B,Blaschek W

    更新日期:2002-03-01 00:00:00

  • In vitro effects of Panax ginseng in aristolochic acid-mediated renal tubulotoxicity: apoptosis versus regeneration.

    abstract::This in vitro study aimed to determine the effects of a Panax ginseng extract on aristolochic acid-mediated toxicity in HK-2 cells. A methanolic extract of ginseng (50 µg/mL) was able to reduce cell survival after treatment with 50 µM aristolochic acid for 24, 48, and 72 h, as evidenced by a resazurin reduction assay....

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0035-1545839

    authors: Bunel V,Antoine MH,Nortier J,Duez P,Stévigny C

    更新日期:2015-03-01 00:00:00

  • Antineoplastic agents. II. Four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca.

    abstract::During activity-guided fractionations to screen for antineoplastic agents, further studies by means of preparative HPLC led to the isolation of four known furostanol saponins: protoneodioscin, protodioscin, protoneogracillin, protogracillin, along with their corresponding artifacts: methyl protoneodioscin, methyl prot...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957636

    authors: Hu K,Dong A,Yao X,Kobayashi H,Iwasaki S

    更新日期:1997-04-01 00:00:00

  • Unusual amino acids and monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a toxic plant from Rwanda.

    abstract::In the course of our investigations on Umutambasha in order to identify its convulsant principles, small quantities of monofluoroacetate were observed in stem bark, leaves, and fruits of this plant newly identified as Dichapetalum michelsonii Hauman. Conclusive evidence for a monofluoroacetate presence came from its i...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328283

    authors: Esters V,Karangwa C,Tits M,Francotte P,Pirotte B,Servais AC,Fillet M,Crommen J,Robbrecht E,Minet A,Grisar T,Angenot L,Frederich M

    更新日期:2013-03-01 00:00:00

  • Jasamplexosides A, B and C: Novel Dimeric and Trimeric Secoiridoid Glucosides from Jasminum amplexicaule.

    abstract::Three new secoiridoid glucosides, jasamplexosides A, B and C, were isolated from the crude drug "Niu du teng", the leaves and stems of JASMINUM AMPLEXICAULE, together with the known secoiridoid glucosides, 10-hydroxyligstroside and jasminoside. Their structural elucidation by spectroscopic studies is described. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961548

    authors: Tanahashi T,Shimada A,Nagakura N,Nayeshiro H

    更新日期:1992-12-01 00:00:00

  • The alkaloid 4-methylaaptamine isolated from the sponge Aaptos aaptos impairs Herpes simplex virus type 1 penetration and immediate-early protein synthesis.

    abstract::We describe in this paper that the alkaloid 4-methylaaptamine, isolated from the marine sponge Aaptos aaptos, inhibited HSV-1 infection. We initially observed that 4-methylaaptamine inhibited HSV-1 replication in Vero cells in a dose-dependent manner with an EC50 value of 2.4 microM. Moreover, the concentration requir...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-967109

    authors: Souza TM,Abrantes JL,de A Epifanio R,Leite Fontes CF,Frugulhetti IC

    更新日期:2007-03-01 00:00:00

  • High performance liquid chromatography in phytochemical analysis of Eurycoma longifolia.

    abstract::An analytical method using HPLC with UV detection was developed to investigate the quassinoid content of Eurycoma longifolia Jack (Simaroubaceae) collected from various sources. Eurycomanone (1), longilactone (2), 14,15beta-dihydroxyklaineanone (3), 15beta-acetyl-14-hydroxyklaineanone (4), 6alpha-hydroxyeurycomalacton...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957570

    authors: Chan KL,Choo CY,Morita H,Itokawa H

    更新日期:1998-12-01 00:00:00

  • Cytotoxic limonoids from Melia azedarach.

    abstract::Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328069

    authors: Yuan CM,Zhang Y,Tang GH,Li Y,He HP,Li SF,Hou L,Li XY,Di YT,Li SL,Hua HM,Hao XJ

    更新日期:2013-01-01 00:00:00

  • Inhibition of butyrylcholinesterase activity by some isoquinoline alkaloids.

    abstract::The inhibition of butyrylcholinesterase activity in human serum by protoberberine, benzophenanthridine and aporphine alkaloids as well as four model compounds has been studied. The mechanism of the inhibition is discussed on the basis of the different types of interaction of these compounds with butyrylcholinesterase ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969916

    authors: Ulrichová J,Walterová D,Preininger V,Simánek V

    更新日期:1983-07-01 00:00:00

  • Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis.

    abstract::Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958094

    authors: Haraguchi H,Saito T,Okamura N,Yagi A

    更新日期:1995-08-01 00:00:00

  • Labdane diterpenoids and shikimic acid derivatives from Araucaria cunninghamii.

    abstract::Four new (1-4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ENT-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ENT-19-( E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid N-butyl ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250570

    authors: Chen J,Chen JJ,Yang LQ,Hua L,Gao K

    更新日期:2011-03-01 00:00:00

  • Molecular Identification Based on Chloroplast Sequences and Anti-complementary Activity Comparison of Juniperus Samples from the Qinghai-Tibet Plateau.

    abstract::Juniperus (Cupressaceae, Pinales) plants are widely distributed in the Qinghai-Tibet Plateau of China. The leaves and twigs of at least 8 Juniperus species (J. pingii, J. pingii var. wilsonii, J. squamata, J. recurva var. coxii, J. saltuaria, J. indica, J. tibetica and J. convallium var. microsperma) have been used as...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1194-0471

    authors: Yang YT,De J,Fu ZL,Wang XL,Chen DF,Xie H,Lu Y

    更新日期:2020-11-01 00:00:00

  • Novel bioactive dammarane caffeoyl esters from Celastrus rosthornianus.

    abstract::Three new dammar-type triterpenoid caffeates (1-3) were isolated from the stalks of Celastrus rosthornianus Loes. Their structures were established through various spectral studies as 3beta,20(S),24(S)-trihydroxyldammar-25-ene 3-caffeate (1), 3beta,20(S),24(R)-trihydroxyldammar-25-ene 3-caffeate (2) and 3beta,20(S),25...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-916214

    authors: Wang KW,Sun CR,Wu XD,Pan YJ

    更新日期:2006-03-01 00:00:00

  • New and cytotoxic anthraquinones from Pleospora sp. IFB-E006, an endophytic fungus in Imperata cylindrical.

    abstract::In addition to 7-methoxy-2-methyl-3,4,5-trihydroxyanthraquinone (1), physcion (2), macrosporin (3), deoxybostrycin (4), altersolanol B (5) and dactylariol (6), a new hexahydroanthraquinone named pleospdione (7) was isolated from the culture of Pleospora sp . IFB-E006, an endophytic fungus residing in the normal stem o...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-864190

    authors: Ge HM,Song YC,Shan CY,Ye YH,Tan RX

    更新日期:2005-11-01 00:00:00

  • Stellera chamaejasme and Its Main Compound Luteolin 7-O-Glucoside Alleviates Skin Lesions in Oxazolone- and 2,4-Dinitrochlorobenzene-Stimulated Murine Models of Atopic Dermatitis.

    abstract::Stellera chamaejasme, also known as "Langdu", has been traditionally used for the management of skin-related diseases such as psoriasis and skin ulcers. The aim of this study was to determine whether S. chamaejasme and its major component, luteolin 7-O-glucoside, have a preventive effect on the development of atopic d...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-0746-8698

    authors: Jo BG,Park NJ,Jegal J,Choi S,Lee SW,Yi LW,Kim SN,Yang MH

    更新日期:2019-05-01 00:00:00

  • alpha-Glucosidase inhibitors from Commelina communis.

    abstract::A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyrano...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960803

    authors: Kim HS,Kim YH,Hong YS,Paek NS,Lee HS,Kim TH,Kim KW,Lee JJ

    更新日期:1999-06-01 00:00:00

  • A new diterpene from Tanaecium jaroba.

    abstract::One new diterpene, 2 alpha-hydroxy-12beta-hydroxy-isopimara-8(14), 15-diene, and six known compounds as triterpenes, sterols and fatty acid, were isolated from the stem bark of Tanaecium jaroba (Bignoniaceae), a Bolivian plant used in traditional medicine. Their structures were established mainly by 1D and 2D NMR (COS...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-32553

    authors: Mitaine-Offer AC,Sauvain M,Deharo E,Muñoz V,Zèches-Hanrot M

    更新日期:2002-06-01 00:00:00

  • Inhibition of platelet aggregation by shikonin derivatives isolated from Arnebia euchroma.

    abstract::Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetylshikonin (IC50...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959718

    authors: Chang YS,Kuo SC,Weng SH,Jan SC,Ko FN,Teng CM

    更新日期:1993-10-01 00:00:00

  • Acridone Alkaloids from Cell Suspension Cultures of Thamnosma montana.

    abstract::Cell Suspension cultures of THAMNOSMA MONTANA were grown in Gamborg B5 medium which was best suited for acridone alkaloid formation. From the lyophilized cell material nine acridones and three acridone-monoglucosides have been isolated which were found for the first time in the genus THAMNOSMA. Moreover, N-methylacrid...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959437

    authors: Baumert A,Maier W,Matern U,Schmidt J,Schumann B,Gröger D

    更新日期:1994-04-01 00:00:00

  • Phenolic Compounds as Arginase Inhibitors: New Insights Regarding Endothelial Dysfunction Treatment.

    abstract::Endothelial dysfunction is characterised by the low bioavailability of nitric oxide with a relevant negative impact on the nitric oxide/cGMP pathway. The loss of nitric oxide/cGMP signaling may be caused by an increased arginase activity. Plant-derived substances, especially polyphenols, are compounds that have the po...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0044-100398

    authors: Minozzo BR,Fernandes D,Beltrame FL

    更新日期:2018-03-01 00:00:00

  • Galanthindole: a new indole alkaloid from Galanthus plicatus ssp. byzantinus.

    abstract::A new indole alkaloid, galanthindole, was isolated from Galanthus plicatus ssp. byzantinus (Amaryllidaceae), a plant native to northwestern Turkey. Incorporating a non-fused indole ring, galanthindole may represent the prototype of a new subgroup of the Amaryllidaceae alkaloids. Two other bases, (+)-11-hydroxyvittatin...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2003-43206

    authors: Unver N,Kaya GI,Werner C,Verpoorte R,Gözler B

    更新日期:2003-09-01 00:00:00

  • Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats.

    abstract::ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-122344

    authors: Anukunwithaya T,Tantisira MH,Tantisira B,Khemawoot P

    更新日期:2017-05-01 00:00:00

  • In vitro evaluation and pharmacokinetics in dogs of solid dispersion pellets containing Silybum marianum extract prepared by fluid-bed coating.

    abstract::The solid dispersion of a poorly water-soluble Silybum marianum extract (SME) was prepared by a one-step fluid-bed coating technique depositing onto non-pareil pellets. In vitro evaluation indicated that this technique was highly efficient and reproducible producing pellets with acceptable appearance, flowability, fri...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034294

    authors: Sun N,Zhang X,Lu Y,Wu W

    更新日期:2008-02-01 00:00:00

  • Novel Piperidine and 3,4-dihydro-2H-pyrrole Alkaloids from Tilia platyphyllos and Tilia cordata Flowers.

    abstract::Lime flowers, traditionally used for medical purposes for the treatment of symptoms of the common cold and mental stress, consist of the dried inflorescences including the floral bracts of Tilia cordata, Tilia platyphyllos, Tilia × vulgaris, or mixtures thereof. During phytochemical investigations, 6 different alkaloi...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1340-0099

    authors: Symma N,Bütergerds M,Sendker J,Petereit F,Hake A,Düfer M,Hensel A

    更新日期:2021-01-12 00:00:00

  • Assessment of the anti-HIV activity of a pine cone isolate.

    abstract::Characterization of an alkali-soluble isolate from Pinus nigra Arnold (Pinaceae) seed cones by thioacidolysis revealed a significant phenylpropanoid (i.c. lignin) component which may provide the observed anti-HIV-1 activity for this substance. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957801

    authors: Eberhardt TL,Young RA

    更新日期:1996-02-01 00:00:00

  • Phillyrin, a natural lignan, attenuates tumor necrosis factor α-mediated insulin resistance and lipolytic acceleration in 3T3-L1 adipocytes.

    abstract::In obese adipose tissue, tumor necrosis factor-α secreted from macrophages plays an important role in the adipocyte dysfunctions, including insulin resistance, lipolytic acceleration, and changes of adipokines, which promote the development of obesity-related complications. Phillyrin, an active ingredient found in man...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0034-1368614

    authors: Kong P,Zhang L,Guo Y,Lu Y,Lin D

    更新日期:2014-07-01 00:00:00

  • Biosynthesis of phenylalanine and tyrosine in claviceps.

    abstract::Some enzymes of the terminal steps of phenylalanine and tyrosine biosyntheses were investigated in various alkaloid-forming ergot strains. All strains studied utilize both arogenate and phenylpyruvate as an intermediate in L-phenylalanine synthesis. L-Tyrosine is preferentially or exclusively synthesized via the aroge...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969195

    authors: Schmauder HP,Gröger D

    更新日期:1986-10-01 00:00:00

  • Post-genome research on the biosynthesis of ergot alkaloids.

    abstract::Genome sequencing provides new opportunities and challenges for identifying genes for the biosynthesis of secondary metabolites. A putative biosynthetic gene cluster of fumigaclavine C, an ergot alkaloid of the clavine type, was identified in the genome sequence of ASPERGILLUS FUMIGATUS by a bioinformatic approach. Th...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-2006-947195

    authors: Li SM,Unsöld IA

    更新日期:2006-10-01 00:00:00

  • Inhibitory effects of the essential oil of Mentha pulegium on the isolated rat myometrium.

    abstract::The effects of the essential oil of Mentha pulegium L. (EOMP), a plant commonly known as "pennyroyal" or "poejo" that is used in folk medicine as an abortifaceant, were assessed on the isolated rat myometrium. Myometrial strips were stimulated with 10 nM oxytocin or 10 microM PGF (2alpha). EOMP (10 - 300 microg/mL) co...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-837819

    authors: Soares PM,Assreuy AM,Souza EP,Lima RF,Silva TO,Fontenele SR,Criddle DN

    更新日期:2005-03-01 00:00:00