Abstract:
:Three new azaphilones, chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3), and two new chlorinated phenolic glycosides, globosumoside A (4) and globosumoside B (5), were isolated from the crude extract of the fungal strain Chaetomium elatum No. 89-1-3-1. Their structures were determined by detailed NMR and MS spectroscopic analyses. The absolute configurations of C-7 in chaetomugilin S (1), 7,5'-bis-epi-chaetoviridin A (2), and 7-epi-chaetoviridin E (3) were assigned by CD experiments, and the absolute configurations of 1 and 2 were established by X-ray crystallography. Compounds 1-3 are the first examples of 7R-configurated azaphilones with a chlorinated isochromen from Chaetomium spp. In addition, compounds 1-3 showed inhibitory activity in the cysteine aspartyl-specific protease-3 (caspase-3) enzymatic assay, with IC₅₀ values of 20.6, 10.9, and 7.9 µM, respectively.
journal_name
Planta Medjournal_title
Planta medicaauthors
Chen GD,Li YJ,Gao H,Chen Y,Li XX,Li J,Guo LD,Cen YZ,Yao XSdoi
10.1055/s-0032-1315211subject
Has Abstractpub_date
2012-10-01 00:00:00pages
1683-9issue
15eissn
0032-0943issn
1439-0221journal_volume
78pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::Several synthetic aromatase inhibitors are currently in clinical use for the treatment of postmenopausal women with hormone-receptor positive breast cancer. However, these treatments may lead to untoward side effects and so the search for new aromatase inhibitors continues, especially those for which the activity is p...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1250169
更新日期:2010-08-01 00:00:00
abstract::This Paper describes an improved HPLC method for the determination of pentacyclic oxindole alkaloids in Uncaria tomentosa (Cat's Claw). Six of the isomeric compounds could be baseline separated at room temperature within less than 30 min by using 3 microm C-18 column material and a mobile phase consisting of 10 mM pho...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2001-15824
更新日期:2001-07-01 00:00:00
abstract::The absolute stereostructure of a novel skeletal diterpene, standishinal (1), from the bark of Thuja standishii was confirmed by X-ray crystallographic analyses of 1 and its p-bromobenzoate derivative. Aromatase inhibitory activities of standishinal, eight known diterpenes, totarol, 12-methoxyabieta-8,11,13-trien-11-o...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2002-33787
更新日期:2002-08-01 00:00:00
abstract::Helanalin, a sesquiterpene lactone antineoplastic agent, is toxic at therapeutic doses in murine tumors. The toxicity has been assumed to be correlated with the binding of the drug to cellular thiol groups. Studies were undertaken to increase the intracellular level of GSH in the liver, kidney and other tissues to eli...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962083
更新日期:1989-12-01 00:00:00
abstract::Micellar electrokinetic capillary chromatography (MECC), using a phosphate buffer pH 7.0 and sodium dodecyl sulfate as the surfactant, was found suitable for the separation of structurally similar flavan-3-ols and related dimeric proanthocyanidins. A total of 20 substances has been tested, 17 of which were successfull...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957368
更新日期:1998-02-01 00:00:00
abstract::The composition and the antimicrobial activity of the essential oil from the leaves of Peumus boldus is investigated. Analyses of the oil obtained by hydrodistillation were carried out by GC and GC-MS using columns of two different stationary phases. Fractionation of the essential oil by column chromatography on silic...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960461
更新日期:1999-03-01 00:00:00
abstract::Capillary GC, GC-MS, IR, GC-IR, (1)H- and (13)C-NMR studies of the essential oil from the leaves and cones of ELSHOLTZIA POLYSTACHYA collected from two different locations in India revealed that one oil contained 1,8-cineol (37.3%), the other one perillene (61.2%) as the main constituent. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961490
更新日期:1992-08-01 00:00:00
abstract::Reinvestigating the constituents of the roots of Vitis thunbergii Sieb. & Zucc. led to the isolation of three new resveratrol derivatives, vitisinols E-G (1-3), together with 14 known compounds. The structures of compounds 1-3 were established by application of spectroscopic analyses (NMR, MS, UV, and IR). ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1185404
更新日期:2009-06-01 00:00:00
abstract::Four p-terphenyl derivatives named curtisians I-L (1-4) were isolated from the MeOH extract of the fruit bodies of Paxillus curtisii. Their structures were elucidated by 2D NMR, MS, IR and UV spectroscopy and chemical reaction. The absolute configurations of curtisians were determined by GC-MS on a chiral column of th...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-45159
更新日期:2003-11-01 00:00:00
abstract::Gleditsioside E, a triterpene saponin isolated from Gleditsia sinensis, showed significant cytotoxicity against Bel-7402, BGC-823, HeLa, HL-60 and MCF-7 cell lines. The results of flow cytometry with annexin V-FITC/PI double staining proved that gleditsioside E mainly induced early apoptosis in HL-60 cells. Gleditsios...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-40645
更新日期:2003-06-01 00:00:00
abstract::The active ingredient dl-tetrahydropalmatine (THP) isolated from the traditional Chinese herb Corydalis racemosa has been found to have antihypertensive effects. However, severe cardiac and neurological toxic effects were reported from using this herb for the treatment of pain. In an isolated perfused rat heart model,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-1999-13998
更新日期:1999-05-01 00:00:00
abstract::Menopause is characterized by deep metabolic disturbances, including decreased insulin sensitivity, adiposity, and changes in lipid profiles. Estrogen replacement therapy can partially reverse these changes, and while it is safe in most healthy postmenopausal women, there are still existing concerns regarding an incre...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0835-6622
更新日期:2019-04-01 00:00:00
abstract::The mechanism of action, leakage of cytochrome c from mitochondria into cytosol, for the antineoplastic compound glyfoline was examined. Additionally, our current studies revealed that glyfoline induced apoptotic changes and arrested cell cycle procession at the G2/M phase in nasopharyngeal carcinoma (NPC). A reverse ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-837747
更新日期:2005-01-01 00:00:00
abstract::The aggregation of the microtubule-associated protein tau is a significant event in many neurodegenerative diseases including Alzheimer's disease. The inhibition or reversal of tau aggregation is therefore a potential therapeutic strategy for these diseases. Fungal natural products have proven to be a rich source of u...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1360180
更新日期:2014-01-01 00:00:00
abstract::Three new depsidones, parmosidones F - G (1 - 2), and 8'-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A - C (4 - 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive sp...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1203-0623
更新日期:2020-11-01 00:00:00
abstract::Three new β-indoloquinazoline alkaloids, orirenierine A (1), B (2) and C (4), together with eleven known compounds were isolated from the methanol extract of the stems of Oricia renieri. The structures of all compounds were determined by comprehensive analyses of their spectroscopic data and comparison with literature...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280227
更新日期:2012-01-01 00:00:00
abstract::Four isocedrenes (1: - 4: ), including one new compound (2: ), were isolated from an ethanolic extract of the aerial parts of Perezia multiflora by bioactivity-guided fractionation. For compounds 1: and 3: , a revised stereochemical assignment is proposed based on molecular modeling studies using DFT-NMR calculations...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-1298-4706
更新日期:2020-11-23 00:00:00
abstract::The effect of extracts of MOMORDICA CHARANTIA L. fruits on glucose metabolism and glucose uptake was investigated. The fruit of momordica, at all ripening stages, was found to contain two inhibitory compounds: one against hexokinase activity and the other against glucose uptake by rat intestinal fragments. Both inhibi...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969380
更新日期:1985-02-01 00:00:00
abstract::Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. In addition to the poor survival rates, combinations using gemcitabine as a backbone have failed to show any benefit beyond monotherapy. These facts underscore an urgent need for novel therapeutic options and mot...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1249931
更新日期:2010-08-01 00:00:00
abstract::Ligusticum canbyi (J.M. Coult & Rose) is a medicinal understory forest species used in traditional rituals and ceremonies for spiritual enlightenment and improved mental health. Very little is known about the phytochemical complexity or diversity of L. canbyi tissues or extracts. The current study was undertaken to de...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1350618
更新日期:2013-09-01 00:00:00
abstract::Bioassay-guided fractionation of the hexanic root bark extract of Casearia sylvestris var. lingua led to the isolation of a new clerodane diterpene, whose structure was elucidated as rel-(2 S,5 R,6 R,8 S,9 S,10 R,18 S,19 R)-19-acetoxy-18,19-epoxy-6-hydroxy-18-butanoyloxy-2-(2-methylbutanoyloxy)cleroda-3,13(16), 14-tri...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-832655
更新日期:2004-11-01 00:00:00
abstract::In the course of our screening program for acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat live...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957763
更新日期:1997-12-01 00:00:00
abstract::The inhibitory effects of selected phenolic lichen substances were tested against a panel of methicillin- and multidrug-resistant Staphylococcus aureus. Depsidones with long alkyl chains on both of the aromatic rings were consistently active against the strains tested, comparable to or better than the level of clinica...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957070
更新日期:2007-02-01 00:00:00
abstract::Raspberry ketone (RK) is a natural phenolic compound of the red raspberry. The dietary administration of RK to male mice has been reported to prevent high-fat diet-induced elevation in body weight and to increase lipolysis in white adipocytes. To elucidate a possible mechanism for the antiobesity action of RK, its eff...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1249860
更新日期:2010-10-01 00:00:00
abstract::Several procyanidin dimers and an epicatechin trimer purified from Douglas fir bark tannins were compared with their monomer components (+)-catechin and (-)-epicatechin for their abilities to inhibit the biochemical effects of the potent tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) in mouse epidermis in v...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959466
更新日期:1994-06-01 00:00:00
abstract::Genome sequencing provides new opportunities and challenges for identifying genes for the biosynthesis of secondary metabolites. A putative biosynthetic gene cluster of fumigaclavine C, an ergot alkaloid of the clavine type, was identified in the genome sequence of ASPERGILLUS FUMIGATUS by a bioinformatic approach. Th...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2006-947195
更新日期:2006-10-01 00:00:00
abstract::Eleven sesquiterpenoids have been isolated from the whole plants of Youngia japonica (Asteraceae). Among these sesquiterpenoids, five were identified as new compounds on the basis of spectroscopic methods and chemical analysis. Their structures were 3-oxo-8alpha-(4-hydoxyphenyl)acetoxy-10(14),11(13)-guaiadien-12,6-oli...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916182
更新日期:2006-02-01 00:00:00
abstract::Four new iridoids viz., plumeridoids A, B, and C and epiplumeridoid C were isolated from the stem bark of Plumeria rubra Linn. together with twenty-four known compounds viz., 1-( P-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, P- E-coumaric a...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1240611
更新日期:2010-04-01 00:00:00
abstract::Three new hydroquinone terpenoids with benzogeijerene skeletons, euchroquinols A-C (1- 3), and a new monoterpenylbenzenoid, 9,17-epoxyarnebinol (4), along with five known compounds were isolated from the stem bark of ARNEBIA EUCHROMA. Shikonin (6) exhibited potent anti-HCV activity with a selective index of 43.56, and...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280266
更新日期:2012-01-01 00:00:00
abstract::A novel stilbene glucoside was isolated from the root bark of Morus alba L. (Moraceae), along with mulberroside A, cis-mulberroside A, oxyresveratrol. The structure of the novel stilbene glucoside was determined as oxyresveratrol 3'-O-beta-glucopyranoside. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-957972
更新日期:1996-12-01 00:00:00