Abstract:
:The mechanism of action, leakage of cytochrome c from mitochondria into cytosol, for the antineoplastic compound glyfoline was examined. Additionally, our current studies revealed that glyfoline induced apoptotic changes and arrested cell cycle procession at the G2/M phase in nasopharyngeal carcinoma (NPC). A reverse transcriptase polymerase chain reaction (RT-PCR) showed no specific changes of apoptosis-related gene expression (i. e., bax, ICE-alpha,beta, bcl-2, and c-myc). However, no similar changes were detected in fibroblasts and peripheral lymphocytes after glyfoline treatment suggesting that glyfoline has a higher affinity for tumor cells than for normal cells.
journal_name
Planta Medjournal_title
Planta medicaauthors
Su TL,Huang HM,Wang CK,Wu HC,Lin CTdoi
10.1055/s-2005-837747subject
Has Abstractpub_date
2005-01-01 00:00:00pages
28-32issue
1eissn
0032-0943issn
1439-0221journal_volume
71pub_type
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