Inhibition of intestinal chloride secretion by proanthocyanidins from Guazuma ulmifolia.

Abstract:

:The antisecretory activity of Guazuma ulmifolia bark was examined in rabbit distal colon mounted in an Ussing chamber. Chloride secretion was stimulated by cholera toxin and prostaglandin E2 (PGE2). Guazuma ulmifolia extract (GUE) completely inhibited cholera toxin-induced secretion if the extract was added to the mucosal bath prior to the toxin. Adding the extract after administration of the toxin had no effect on secretion. GUE did not inhibit PGE2-induced chloride secretion. These results indicate an indirect antisecretory mechanism. SDS-PAGE analysis of cholera toxin treated with GUE confirmed this presumption. GUE specifically interacted with the A subunit of the toxin. Preliminary phytochemical examinations showed that the most active fraction contains procyanidins with a degree of polymerisation higher than 8.

journal_name

Planta Med

journal_title

Planta medica

authors

Hör M,Rimpler H,Heinrich M

doi

10.1055/s-2006-958057

subject

Has Abstract

pub_date

1995-06-01 00:00:00

pages

208-12

issue

3

eissn

0032-0943

issn

1439-0221

journal_volume

61

pub_type

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