Abstract:
:This Paper describes an improved HPLC method for the determination of pentacyclic oxindole alkaloids in Uncaria tomentosa (Cat's Claw). Six of the isomeric compounds could be baseline separated at room temperature within less than 30 min by using 3 microm C-18 column material and a mobile phase consisting of 10 mM phosphate buffer at pH 7.0 and acetonitrile. At a wavelength of 245 nm all standard compounds could be detected at concentrations as low as 0.63 microg/ml. Different samples of U. tomentosa bark and market products containing Cat's Claw were extracted with a modified procedure ensuring the integrity of the alkaloids and analyzed successfully. The results indicated accuracy and consistency of the new method, and showed variations in the total alkaloid content in products from 0.156 to 0.962%.
journal_name
Planta Medjournal_title
Planta medicaauthors
Ganzera M,Muhammad I,Khan RA,Khan IAdoi
10.1055/s-2001-15824subject
Has Abstractpub_date
2001-07-01 00:00:00pages
447-50issue
5eissn
0032-0943issn
1439-0221journal_volume
67pub_type
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