Inhibition of rat adjuvant-induced arthritis by ginkgetin, a biflavone from ginkgo biloba leaves.

Abstract:

:Ginkgetin, a biflavone isolated from Ginkgo biloba leaves, was previously reported as an inhibitor of group II phospholipase A2. In this study, ginkgetin was evaluated for in vivo antiarthritic and analgesic activities. Ginkgetin (10-20 mg/kg/day) strongly reduced arthritic inflammation in an animal model of rat adjuvant-induced arthritis (86% inhibition at 16 days at a dose of 20 mg/kg/day) via intraperitoneal injection, while prednisolone (5 mg/kg/day) showed 79% reduction. Histological examination of the knee joints confirmed our findings. When analgesic activity was measured, ginkgetin showed a dose-dependent inhibition in an animal model of acetic acid-induced writhing. ED50 values for ginkgetin and indomethacin were 8.9 and 3.8 mg/kg, respectively. All these results indicate that ginkgetin may be a potential antiarthritic agent having analgesic activity.

journal_name

Planta Med

journal_title

Planta medica

authors

Kim HK,Son KH,Chang HW,Kang SS,Kim HP

doi

10.1055/s-2006-960815

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

465-7

issue

5

eissn

0032-0943

issn

1439-0221

journal_volume

65

pub_type

信件
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  • Reversal caused by n-butylidenephthalide from the deficits of inhibitory avoidance performance in rats.

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  • A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.

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    更新日期:2007-10-01 00:00:00

  • Stimulatory effects of ingenols from Euphorbia kansui on the expression of macrophage Fc receptor.

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  • Modified Aloe barbadensis polysaccharide with immunoregulatory activity.

    abstract::Aloe barbadensis polysaccharide was partially digested with cellulase and further purified by dialysis, stepwise ethanol precipitation, and size exclusion chromatography. Crude modified Aloe polysaccharide (MAP) activated macrophage cells and stimulated fibroblast growth. Under the same conditions, native Aloe barbade...

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  • Aged garlic extract and its constituents inhibit Cu(2+)-induced oxidative modification of low density lipoprotein.

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  • ISSR-Derived Species-Specific SCAR Marker for Rapid and Accurate Authentication of Ocimum tenuiflorum L.

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  • A New Iridoid Glucoside of Swertia japonica.

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  • Effects of Sideritis scardica Extract on Glucose Tolerance, Triglyceride Levels and Markers of Oxidative Stress in Ovariectomized Rats.

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