Stabilization of growth factors relevant to wound healing by a plant cell wall biomaterial.

Abstract:

:Stabilization of growth factors in a wound environment is critical to the wound healing process. Here we report on the stabilization of key growth factors by a unique plant cell wall biomaterial. MicroSheets are clear cell wall fragments isolated from the non-living water storage cells in the pulp or inner gel of Aloe vera L., which has widely been used for wound healing. It was found that MicroSheets bind to a subset of heparin binding growth factors including basic fibroblast growth factor (bFGF) and keratinocyte growth factor (KGF), two key growth factors in the wound healing process. The binding of bFGF and KGF to MicroSheets was inhibited by heparin and also by a pectic substance isolated from the MicroSheets, indicating that the binding was mediated by this pectic component of the MicroSheet. The binding protected the growth factors against protease digestion. Furthermore, the protective effect was also demonstrated with KGF against digestion by wound fluids and by measuring the biological activity. Thus, these results showed that MicroSheets can stabilize certain critical growth factors in wounds and thereby promote the healing process. Incorporation of a material like MicroSheets provides an important functional element in wound dressings, i. e., growth factor stabilization.

journal_name

Planta Med

journal_title

Planta medica

authors

Ni Y,Turner D,Yates K,Tizard I

doi

10.1055/s-2007-990225

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

1260-6

issue

12

eissn

0032-0943

issn

1439-0221

journal_volume

73

pub_type

杂志文章
  • Jasamplexosides A, B and C: Novel Dimeric and Trimeric Secoiridoid Glucosides from Jasminum amplexicaule.

    abstract::Three new secoiridoid glucosides, jasamplexosides A, B and C, were isolated from the crude drug "Niu du teng", the leaves and stems of JASMINUM AMPLEXICAULE, together with the known secoiridoid glucosides, 10-hydroxyligstroside and jasminoside. Their structural elucidation by spectroscopic studies is described. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961548

    authors: Tanahashi T,Shimada A,Nagakura N,Nayeshiro H

    更新日期:1992-12-01 00:00:00

  • Studies on the Turnover of Cardenolides in Convallaria majalis.

    abstract::In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2) and the subsequent...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969527

    authors: Schrutka-Rechtenstamm R,Kopp B,Löffelhardt W

    更新日期:1985-10-01 00:00:00

  • XVIII: Eperudiendiol, Glycerides and Neolignans from Fruits of Osteophloeum platyspermum1.

    abstract::The fruits of OSTEOPHLOEUM PLATYSPERMUM (Myristicaceae) contain sitosterol, eperu-8(20),13-dien-3alpha,15-diol, glyceryl laurodimyristate, glyceryl 1,3-lauromyristate and five neolignans: dihydroguaiaretic acid, hydroxyotobain, hydroxyoxootobain, guaiacin and otobaphenol. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969620

    authors: Fo RB,de Carvalho MG,Gottlieb OR

    更新日期:1984-02-01 00:00:00

  • Evaluation of the anti-trypanosomal activity of tyropeptin A.

    abstract::The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times low...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-931600

    authors: Steverding D,Pemberton AJ,Royle H,Spackman RW,Rivett AJ

    更新日期:2006-06-01 00:00:00

  • Cryptic and free skin irritants of the daphnane and tigliane types in latex of Excoecaria agallocha.

    abstract::In the extremely skin irritant and caustic latex of Excoecaria agallocha the major part of the polyfunctional diterpene esters (DTE) (group I) are aliphatic polyunsaturated 9,13,14-orthoesters of the daphnane-type parent alcohol 5 beta-hydroxyresiniferonol-6 alpha, 7 alpha-epoxide, esterified simultaneously in their 2...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959499

    authors: Karalai C,Wiriyachitra P,Opferkuch HJ,Hecker E

    更新日期:1994-08-01 00:00:00

  • Sesquiterpenoids from Inula racemosa Hook. f. inhibit nitric oxide production.

    abstract::A novel trinorsesquiterpene (1), three new (2-4), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibit...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1280294

    authors: Zhang SD,Qin JJ,Jin HZ,Yin YH,Li HL,Yang XW,Li X,Shan L,Zhang WD

    更新日期:2012-01-01 00:00:00

  • New oligospirostanosides and oligofurostanosides from Asparagus adscendens roots.

    abstract::The methanol extract of the defatted roots of Asparagus adscendens Roxb. yielded beta-sitosterol beta-D-glucoside, two new spirostanol glycosides (asparanin C and asparanin D) and two new furostanol glycosides (asparoside C and asparoside D). ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-970018

    authors: Sharma SC,Chand R,Bhatti BS,Sati OP

    更新日期:1982-09-01 00:00:00

  • Gradient x Isocratic Elution CCC on the Isolation of Verbascoside and Other Phenylethanoids: Influence of the Complexity of the Matrix.

    abstract::Verbascoside is a phenylethanoid glycoside widely distributed in nature, especially among the order Lamiales, occurring in numerous plants that are constituents of folk medicine preparations. This natural compound, previously isolated by our group from the ethyl acetate extract of Lantana trifolia using the gradient a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0035-1546116

    authors: Leitão GG,Pinto SC,de Oliveira DR,Timoteo P,Guimarães MG,Cordova WH,Leitão SG

    更新日期:2015-11-01 00:00:00

  • Allicin characterization and its determination by HPLC.

    abstract::Allicin has been synthesized and was purified by liquid chromatography. HPLC chromatograms recorded at different wavelengths reveal pure allicin at similar retention times. The purity of the allicin peak could be confirmed by diode array detection. Pure synthetic allicin has been identified by infrared and mass spectr...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962811

    authors: Jansen H,Müller B,Knobloch K

    更新日期:1987-12-01 00:00:00

  • Polyacetylene analogs, isolated from hairy roots of Panax ginseng, inhibit Acyl-CoA : cholesterol acyltransferase.

    abstract::In the course of our screening program for acyl-CoA : cholesterol acyltransferase (ACAT) inhibitors from Korean herbal medicines, ACAT inhibitors were isolated from the hairy roots of Panax ginseng (Araliaceae) and identified as panaxynol, panaxydol, panaxydiol, and panaxytriol. These active compounds inhibit rat live...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957763

    authors: Kwon BM,Ro SH,Kim MK,Nam JY,Jung HJ,Lee IR,Kim YK,Bok SH

    更新日期:1997-12-01 00:00:00

  • Two New Anthraquinones from the Seeds of Peganum harmala.

    abstract::Two new anthraquinones have been isolated from the seeds of PEGANUM HARMALA Linn and the structures established as 3,6-dihydroxy-8-methoxy-2-methylanthraquinone (peganone; 1) and 8-hydroxy-7-methoxy-2-methylanthraquinone (peganone; 2) by spectral correlations and chemical evidences. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962639

    authors: Pitre S,Srivastava SK

    更新日期:1987-02-01 00:00:00

  • Insulinotropic effect of Citrullus colocynthis fruit extracts.

    abstract::Infusions of Citrullus colocynthis Schrad. (Cucurbitaceae) fruits are traditionally used as antidiabetic medication in Mediterranean countries, but to our knowledge no studies have been undertaken so far to determine the possible mechanisms involved in the antidiabetic properties of the fruit. The present study was de...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2000-8586

    authors: Nmila R,Gross R,Rchid H,Roye M,Manteghetti M,Petit P,Tijane M,Ribes G,Sauvaire Y

    更新日期:2000-06-01 00:00:00

  • Encelin: a fungal growth inhibitor.

    abstract::A known sesquiterpene lactone, encelin, isolated from the Mexican species Montanoa speciosa (Compositae), was assayed for biocidal activity on fungal cells of Mucor rouxii. The results indicate that encelin has a determining action on growth and the morphogenetic process of fungal cells. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958046

    authors: Sabanero M,Quijano L,Rios T,Trejo R

    更新日期:1995-04-01 00:00:00

  • Inhibitory activity of stilbenes from medicinal plants on the expression of cell adhesion molecules on THP1 cells.

    abstract::The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1)...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2000-8634

    authors: Ahn KS,Kim JH,Oh SR,Ryu SY,Lee HK

    更新日期:2000-10-01 00:00:00

  • Separation and determination of coumarins in the root bark of three citrus plants by micellar electrokinetic capillary chromatography.

    abstract::A micellar electrokinetic capillary chromatography (MEKC) method for the determination of xanthyletin and xanthoxyletin in the roots bark of three Citrus plants was developed for the first time. The electrophoresis buffer was 10 mmol/L sodium borate containing 50 mmol/L sodium dodecyl sulfate, 20% (v/v) acetonitrile a...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2003-39697

    authors: Wang SF,Ju Y,Chen XG,Hu ZD

    更新日期:2003-05-01 00:00:00

  • African medicinal plants with antidiabetic potentials: a review.

    abstract::Diabetes mellitus is one of the major health problems in Africa. The conventional oral synthetic antidiabetic drugs available to manage the disease are costly and not readily affordable to the majority of the affected population. Interestingly, the continent is endowed with a tremendous number of medicinal plants that...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1360335

    authors: Mohammed A,Ibrahim MA,Islam MS

    更新日期:2014-03-01 00:00:00

  • Inhibition of prostate cancer (LNCaP) cell proliferation by volatile components from Nagami kumquats.

    abstract::Fresh Nagami kumquats (Fortunella margarita) were subjected to hydrodistillation using a Clevenger-type apparatus to obtain volatile oil. The chemical composition of the volatile oil was analyzed by GC-MS using Rtx-5 Sil MS and DB Wax columns. A total of 25 volatile compounds were identified by mass spectra, retention...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1298619

    authors: Jayaprakasha GK,Murthy KN,Demarais R,Patil BS

    更新日期:2012-06-01 00:00:00

  • A new cytotoxic trichothecene macrolide from the endophyte Myrothecium roridum.

    abstract::A new cytotoxic roridin-type trichothecene macrolide named roritoxin E(1) was characterized from the solid culture of Myrothecium roridum IFB-E091 (residing originally inside Artemisia annua root), together with the known compounds lumichrome (2), (22 E,24 S)-cerevisterol (3), and (22 E,24 R)-6 beta-methoxy-ergosta-7,...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-0029-1240897

    authors: Shen L,Wang JS,Shen HJ,Song YC,Tan RX

    更新日期:2010-07-01 00:00:00

  • Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes.

    abstract::In this study we investigate the active constituents of the rhizome of Zingiber officinale, Roscoe (ginger) and determine their activity on glucose uptake in cultured L6 myotubes and the molecular mechanism underlying this action. Freeze-dried ginger powder was extracted with ethyl acetate (1 kg/3 L) to give the total...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1315041

    authors: Li Y,Tran VH,Duke CC,Roufogalis BD

    更新日期:2012-09-01 00:00:00

  • Seasonal variation of phenolic constituents and medicinal activities of Northern Labrador tea, Rhododendron tomentosum ssp. subarcticum, an Inuit and cree First Nations traditional medicine.

    abstract::Northern Labrador tea, Rhododendron tomentosum ssp. subarcticum, is one of the most commonly used medicinal plants by Inuit and other First Nations peoples of Canada. The phenolic profile and seasonal variation of this commonly used medicinal plant remains largely unknown. To assess optimal harvesting time, R. tomento...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1270968

    authors: Black P,Saleem A,Dunford A,Guerrero-Analco J,Walshe-Roussel B,Haddad P,Cuerrier A,Arnason JT

    更新日期:2011-09-01 00:00:00

  • Two new 8-oxotetrahydroprotoberberine alkaloids, gusanlung A and B, from Acangelisia gusanlung.

    abstract::Two new 8-oxotetrahydroprotoberberine alkaloids, gusanlung A(1) and B(2), together with known isoquinoline alkaloids, berberine and jatrorrhizine, were isolated from the Chinese medicinal plant Acangelisia gusanlung H. S. Lo (Menispermaceae). Their structures were elucidated mainly by spectroscopic analysis. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960150

    authors: Zhang JS,Chen ZL

    更新日期:1991-10-01 00:00:00

  • Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung.

    abstract::From the roots of UNCARIA TOMENTOSA six oxindol alkaloids have been isolated and identified as isopteropodin, pteropodin, mitraphyllin, isomitraphyllin, rynchophyllin and isorynchophyllin. By ion pair chromatography on HPLC a fingerprint analysis has been worked out which allowed to differentiate between various UNICA...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969537

    authors: Wagner H,Kreutzkamp B,Jurcic K

    更新日期:1985-10-01 00:00:00

  • Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis.

    abstract::Four diterpenoids, carnosic acid (1), carnosol (2), rosmanol (3), and epirosmanol (4), were isolated as antioxidative agents from the leaves of Rosmarinus officinalis by bioassay-directed fractionation. These diterpenoids inhibited superoxide anion production in the xanthine/xanthine oxidase system. Mitochondrial and ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958094

    authors: Haraguchi H,Saito T,Okamura N,Yagi A

    更新日期:1995-08-01 00:00:00

  • Antiplatelet aggregation principles from Ephemerantha lonchophylla.

    abstract::Bioactivity-directed separation led to the identification of four compounds, viz. denbinobin (1), 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2), 3-methylgigantol (3), and erianthridin (4) from the ethanolic extract of Ephemerantha lonchophylla. Antiplatelet tests were carried out using 4 different aggregation inducers, ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2000-8553

    authors: Chen CC,Huang YL,Teng CM

    更新日期:2000-05-01 00:00:00

  • New guaiane sesquiterpene lactones from Ixeris dentata.

    abstract::Three new guaiane-type sesquiterpene lactones (1-3), together with nine related sesquiterpenes (4-12), were isolated from the whole extract of Ixeris dentata (Asteraceae). The chemical structures of isolates 1-12 were established by spectroscopic analyses as 3 β,8 β-dihydroxy-guaia-10(14)-en-1 α,4 α,5 α,6 β,7 α,11 βH-...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250369

    authors: Cha MR,Choi YH,Choi CW,Yoo DS,Kim YS,Choi SU,Kim YH,Ryu SY

    更新日期:2011-03-01 00:00:00

  • Protective effect of Labisia pumila on stress-induced behavioral, biochemical, and immunological alterations.

    abstract::The aim of the present study was to investigate the antistress potential of LABISIA PUMILA aqueous extract (LPPM/A003) using a battery of tests widely employed in different stressful situations. Pretreatment of experimental animals with LPPM/A003 caused an increase in the swimming endurance and hypoxia time and also s...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1240953

    authors: Kour K,Sharma N,Chandan BK,Koul S,Sangwan PL,Bani S

    更新日期:2010-10-01 00:00:00

  • Plectranthus barbatus: a review of phytochemistry, ethnobotanical uses and pharmacology - Part 1.

    abstract::Plectranthus barbatus Andr. is one of the most important species of the genus Plectranthus L' Herit. (Lamiaceae), with a wide variety of traditional medicinal uses in Hindu and Ayurvedic traditional medicine as well as in the folk medicine of Brazil, tropical Africa and China. The plant has therefore been an attractiv...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-0029-1240898

    authors: Alasbahi RH,Melzig MF

    更新日期:2010-05-01 00:00:00

  • Effect of the Hydroethanolic Extract from Echinodorus grandiflorus Leaves and a Fraction Enriched in Flavone-C-Glycosides on Antigen-Induced Arthritis in Mice.

    abstract::The leaves of Echinodorus grandiflorus are traditionally used in Brazil to treat several inflammatory conditions, including arthritis. This study aimed to investigate the antiarthritis activity of the 70% ethanol extract of E. grandiflorus leaves and a standardized flavonoid-rich fraction in an antigen-induced arthrit...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0035-1568200

    authors: Garcia Ede F,de Oliveira MA,Candido LC,Coelho FM,Costa VV,Queiroz-Junior CM,Boff D,Amaral FA,de Souza Dda G,Teixeira MM,Braga FC

    更新日期:2016-03-01 00:00:00

  • Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism.

    abstract::The benzophenanthridine alkaloids sanguinarine and chelerythrine of Chelidonium majus, L. (Papaveraceae), are potent inhibitors of 5-lipoxygenase in polymorphonuclear leukocytes and 12-lipoxygenase in mouse epidermis, while the activity of soybean lipoxygenase is not influenced. The extract of the herb of Ch.majus als...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957924

    authors: Vavrecková C,Gawlik I,Müller K

    更新日期:1996-10-01 00:00:00

  • Structure-activity relationship of triterpenes and triterpenoid glycosides against tobacco mosaic virus.

    abstract::A new activity of triterpenes and triterpenoid glycosides against phytovirus has been found. Based on the anti-TMV replication activity in vivo, 47 triterpenes and triterpenoid glycosides were screened through the leaf-disk method together with indirect ELISA. Structure-activity relationships were analyzed according t...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-990263

    authors: Zhang ZK,Ouyang MA,Wu ZJ,Lin QY,Xie LH

    更新日期:2007-11-01 00:00:00