Benzophenanthridine alkaloids of Chelidonium majus; I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism.

abstract：:The composition of the phthalide mixture of the essential oil from roots of Levisticum officinale Koch was investigated. The phthalide mixture was analyzed by combining separation methods - GLC, LSC and TLC - and subsequently using spectroscopic methods - IR, MS and NMR. E- and Z-butylidenephthalide, E- and Z-ligustil...

journal_title：Planta medica

authors： Gijbels MJ,Scheffer JJ,Baerheim Svendsen A

更新日期：1982-04-01 00:00:00

abstract：:Lime flowers, traditionally used for medical purposes for the treatment of symptoms of the common cold and mental stress, consist of the dried inflorescences including the floral bracts of Tilia cordata, Tilia platyphyllos, Tilia × vulgaris, or mixtures thereof. During phytochemical investigations, 6 different alkaloi...

journal_title：Planta medica

authors： Symma N,Bütergerds M,Sendker J,Petereit F,Hake A,Düfer M,Hensel A

更新日期：2021-01-12 00:00:00

abstract：:For quantitative determination of grayanotoxin I (1) in plant material, a GC/MS method was developed after trimethylsilyl derivatisation of the analytes. Forskolin (5) was used as an internal standard for quantification. ICH-compliant method validation indicated sufficient specificity, precision, quantitation (15 µg/m...

journal_title：Planta medica

authors： Lechtenberg M,Dierks F,Sendker J,Louis A,Schepker H,Hensel A

更新日期：2014-10-01 00:00:00

abstract：:The present study investigated the role of adenosine in the stimulatory action of paeoniflorin on in vitro glucose transport. Paeoniflorin increased the uptake of a radiolabeled, non-metabolizable glucose derivative into isolated white adipocytes of Wistar rat in a concentration-dependent manner and this action was ab...

journal_title：Planta medica

authors： Tang LM,Liu IM,Cheng JT

更新日期：2003-04-01 00:00:00

abstract：:In addition to 7-methoxy-2-methyl-3,4,5-trihydroxyanthraquinone (1), physcion (2), macrosporin (3), deoxybostrycin (4), altersolanol B (5) and dactylariol (6), a new hexahydroanthraquinone named pleospdione (7) was isolated from the culture of Pleospora sp . IFB-E006, an endophytic fungus residing in the normal stem o...

journal_title：Planta medica

authors： Ge HM,Song YC,Shan CY,Ye YH,Tan RX

更新日期：2005-11-01 00:00:00

abstract：:Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. In addition to the poor survival rates, combinations using gemcitabine as a backbone have failed to show any benefit beyond monotherapy. These facts underscore an urgent need for novel therapeutic options and mot...

journal_title：Planta medica

authors： Pinto-Garcia L,Efferth T,Torres A,Hoheisel JD,Youns M

更新日期：2010-08-01 00:00:00

abstract：:The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were...

journal_title：Planta medica

authors： Li L,Nie J,Shen Z,Wu W,Chen Z,Hao X

更新日期：2001-03-01 00:00:00

abstract：:Seven phenolic derivatives, 2,4-bis(4-hydroxybenzyl)phenol ( 1), bis[4(beta- D-glucopyranosyloxy)-benzyl] ( S)-(-)-2-isopropylmalate ( 2), bis[4-(beta- D-gluco-pyranosyloxy)benzyl] ( S)-(-)-2-sec-butylmalate ( 3), 4-hydroxybenzyaldehyde ( 4), 4,4'-dihydroxydiphenyl-methane ( 5), 4-hydroxybenzyl alcohol ( 6), and 4-(be...

journal_title：Planta medica

authors： Yi-Ming L,Zhuo-Lun Z,Yong-Fu H

更新日期：1993-08-01 00:00:00

abstract：:Guinea pigs were sensitized with trinitrophenylated liver macromolecular protein fraction (TNP-LP1) prepared by using sodium trinitrobenzenesulfonate of strong immunogenicity as the hapten and LP1 as the carrier protein. The administration of trinitrophenylated hepatocytes and lipopolysaccharide to these TNP-LP1-sensi...

journal_title：Planta medica

authors： Mizoguchi Y,Shin T,Kobayashi K,Morisawa S

更新日期：1991-02-01 00:00:00

abstract：:This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of ...

journal_title：Planta medica

authors： Chen SD,Li T,Gao H,Zhu QC,Lu CJ,Wu HL,Peng T,Yao XS

更新日期：2013-12-01 00:00:00

abstract：:Three previously undescribed natural products, phomopsinin A - C (1:  - 3: ), together with three known compounds, namely, cis-hydroxymellein (4: ), phomoxanthone A (5: ) and cytochalasin L-696,474 (6: ), were isolated from the solid culture of Phomopsis sp. CAM212, an endophytic fungus obtained from Garcinia xanthoch...

journal_title：Planta medica

authors： Jouda JB,Njoya EM,Fobofou SAT,Zhou ZY,Qiang Z,Mbazoa CD,Brandt W,Zhang GL,Wandji J,Wang F

更新日期：2020-09-01 00:00:00

abstract：:Ent-11alpha-hydroxy-16-kauren-15-one (1) induced apoptosis in a human leukemia cell line (HL-60 cells), however, the apoptosis-inducing properties of 1 and its related compounds remain to be proved. We examined the involvement of caspases, a family of cysteine aspartic proteases, which play a central role in induction...

journal_title：Planta medica

authors： Nagashima F,Kondoh M,Kawase M,Simizu S,Osada H,Fujii M,Watanabe Y,Sato M,Asakawa Y

更新日期：2003-04-01 00:00:00

abstract：:The aerial parts of DODONAEA VISCOSA afforded a new diterpenoid, dodonic acid, the structure and stereochemistry of which have been established by chemical and spectroscopic means. ...

journal_title：Planta medica

authors： Sachdev K,Kulshreshtha DK

更新日期：1984-10-01 00:00:00

abstract：:Novel therapies are needed to address the public health problem posed by methicillin-resistant STAPHYLOCOCCUS AUREUS (MRSA). In this study, we determined the effects of combinations of antibiotics and plant polyphenols against 20 clinical isolates of MRSA. The IN VITRO activities of 10 antibiotics and 15 natural polyp...

journal_title：Planta medica

authors： Lin RD,Chin YP,Hou WC,Lee MH

更新日期：2008-06-01 00:00:00

abstract：:From the roots of PICRORHIZA KURROOA a new iridoid glycoside, 6-feruloylcatalpol has been isolated, along with veronicoside and minecoside and two phenol glucosides, picein and androsin. ...

journal_title：Planta medica

authors： Stuppner H,Wagner H

更新日期：1989-10-01 00:00:00

abstract：:An in vitro propagation protocol for rapidly producing Hydrastis canadensis L., Goldenseal, plantlets from disk tissue of young leaves was developed. Leaf explants were inoculated on MS medium supplemented with various concentrations of NAA and TDZ for production of callus. Two-month-old calli were sub-cultured on MS ...

journal_title：Planta medica

authors： Bedir E,Lata H,Schaneberg B,Khan IA,Moraes RM

更新日期：2003-01-01 00:00:00

abstract：:A crude globulin fraction was isolated from the tubers of Pinellia ternata (Thunb.) Breit. Tubers of P. ternata are one of the well known Chinese traditional medicines. It is used on account of its anti-emetic effect. 6KDP was separated by means of gel filtration and chromatography on CM-Toyopearl 650 M from the crude...

journal_title：Planta medica

authors： Kurata K,Tai T,Yang Y,Kinoshita K,Koyama K,Takahashi K,Watanabe K,Nunoura Y

更新日期：1998-10-01 00:00:00

abstract：:Two new triterpenoid saponins, along with five known ones, were isolated from the EtOH extract of the whole plants of Androsace umbellata. The structures of the new triterpenoid saponins were identified as 3- O-[ beta- D-xylopyranosyl-(1-->2)- beta- D-glucopyranosyl-(1-->4)-[ beta- D-glucopyranosyl-(1-->2)]- alpha- L-...

journal_title：Planta medica

authors： Wang Y,Zhang D,Ye W,Yin Z,Fung KP,Zhao S,Yao X

更新日期：2008-08-01 00:00:00

abstract：:We present the application of the generative topographic map algorithm to visualize the chemical space populated by natural products and synthetic drugs. Generative topographic maps may be used for nonlinear dimensionality reduction and probabilistic modeling. For compound mapping, we represented the molecules by two-...

journal_title：Planta medica

authors： Miyao T,Reker D,Schneider P,Funatsu K,Schneider G

更新日期：2015-04-01 00:00:00

abstract：:Activity-guided fractionation of the dichloromethane extract from leaves of Piper fulvescens, using an agar overlay bioautographic method, led to the isolation of three antifungal neolignans identified as conocarpan, eupomatenoid 5 and eupomatenoid 6. The minimal inhibitory concentration of these three neolignans agai...

journal_title：Planta medica

authors： Freixa B,Vila R,Ferro EA,Adzet T,Cañigueral S

更新日期：2001-12-01 00:00:00

abstract：:The dried rhizome of Panax notoginseng is a traditional Chinese herb extensively used for treatment of cardiovascular diseases and other ailments. Panax notoginseng saponins (PNS) are known as the major pharmacologically active constituents. The purpose of this study was to investigate the cardioprotective effects of ...

journal_title：Planta medica

authors： Liu L,Shi R,Shi Q,Cheng Y,Huo Y

更新日期：2008-02-01 00:00:00

abstract：:Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedat...

journal_title：Planta medica

authors： Lanhers MC,Fleurentin J,Dorfman P,Mortier F,Pelt JM

更新日期：1991-06-01 00:00:00

abstract：:The activity-guided fractionation of the hydroalcoholic extract of trunk bark of Cedrelopsis grevei led to the isolation of five coumarins, norbraylin (1), methyl-O-cedrelopsin (2), cedrecoumarin A (3), scoparone (4) and braylin (5) as a part of the constituents responsible for the vasorelaxing activity observed for t...

journal_title：Planta medica

authors： Rakotoarison O,Rabenau I,Lobstein A,Um BH,Schott C,Anton R,Randriantsoa A,Andriantsitohaina R

更新日期：2003-02-01 00:00:00

abstract：:One new triterpene, kudinchalactone A (1), and four new triterpenoid saponins, ilekudinchosides A-D (2- 5), were isolated from the leaves of Ilex kudincha C. J. Tseng along with eight known triterpenoids. These new compounds were elucidated by spectroscopic methods including 1D and 2D NMR, HR-TOF-MS, and CD spectra. C...

journal_title：Planta medica

authors： Zuo WJ,Dai HF,Chen J,Chen HQ,Zhao YX,Mei WL,Li X,Wang JH

更新日期：2011-11-01 00:00:00

abstract：:Three new lycopodium alkaloids, 11alpha-hydroxyphlegmariurine B (2), 7alpha-hydroxyphlegmariurine B (3) and 7alpha,11alpha-dihydroxyphlegmariurine B (4) along with a known compound, phlegmariurine B (1), were isolated from the herb Huperzia serrata. The structures of the above compounds were elucidated based on spectr...

journal_title：Planta medica

authors： Tan CH,Wang BD,Jiang SH,Zhu DY

更新日期：2002-02-01 00:00:00

abstract：:The present study explores the potential of nanoemulsion, a lipid drug delivery system, to improve solubility and oral absorption of Silybum marianum extract. The optimized formulation contained 40 mg/mL of commercial extract (4 % w/w) and it was composed of 2.5 g labrasol (20 %) as the oil phase, 1.5 g cremophor EL a...

journal_title：Planta medica

authors： Piazzini V,Rosseti C,Bigagli E,Luceri C,Bilia AR,Bergonzi MC

更新日期：2017-10-01 00:00:00

abstract：:Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-...

journal_title：Planta medica

authors： Smejkal K,Slapetová T,Krmenčík P,Babula P,Dall'Acqua S,Innocenti G,Vančo J,Casarin E,Carrara M,Kalvarová K,Dvorská M,Slanina J,Kramářová E,Julínek O,Urbanová M

更新日期：2010-10-01 00:00:00

abstract：:A new BIS-1-oxaquinolizidine alkaloid, 9'- EPI-3 β,3' β-dimethylxestospongin C (2), and three known related analogues have been isolated from the Hainan sponge Neopetrosia exigua. ...

journal_title：Planta medica

authors： Li Y,Qin S,Guo YW,Gu YC,van Soest RW

更新日期：2011-01-01 00:00:00

abstract：:Characterization of an alkali-soluble isolate from Pinus nigra Arnold (Pinaceae) seed cones by thioacidolysis revealed a significant phenylpropanoid (i.c. lignin) component which may provide the observed anti-HIV-1 activity for this substance. ...

journal_title：Planta medica

authors： Eberhardt TL,Young RA

更新日期：1996-02-01 00:00:00

abstract：:Despite the huge diversity of antibacterial compounds, bacterial resistance to first-choice antibiotics has been drastically increasing. Moreover, the association between multiresistant microorganisms and nosocomial infections highlight the problem, and the urgent need for solutions. Natural resources have been exploi...

journal_title：Planta medica

authors： Alves MJ,Ferreira IC,Dias J,Teixeira V,Martins A,Pintado M

更新日期：2012-11-01 00:00:00