Vasorelaxing properties and bio-guided fractionation of Cedrelopsis grevei.

abstract：:Endothelial dysfunction is characterised by the low bioavailability of nitric oxide with a relevant negative impact on the nitric oxide/cGMP pathway. The loss of nitric oxide/cGMP signaling may be caused by an increased arginase activity. Plant-derived substances, especially polyphenols, are compounds that have the po...

journal_title：Planta medica

authors： Minozzo BR,Fernandes D,Beltrame FL

更新日期：2018-03-01 00:00:00

abstract：:Despite the huge diversity of antibacterial compounds, bacterial resistance to first-choice antibiotics has been drastically increasing. Moreover, the association between multiresistant microorganisms and nosocomial infections highlight the problem, and the urgent need for solutions. Natural resources have been exploi...

journal_title：Planta medica

authors： Alves MJ,Ferreira IC,Dias J,Teixeira V,Martins A,Pintado M

更新日期：2012-11-01 00:00:00

abstract：:From the leaves of BLUMEA ARFAKIANA Martelli (Asteraceae), used in traditional medicine in Papua New Guinea, besides stigmasterol and beta-eudesmol, four graniline esters ( 1-4) have been isolated. Furthermore, blumealactone C ( 5), deacetylblumealactone C ( 6), and deoxyblumealactone C ( 7) have been identified. ...

journal_title：Planta medica

authors： Rücker G,Paulini G,Sakulas H,Lawong B,Goeltenboth F

更新日期：1991-06-01 00:00:00

abstract：:Transient receptor potential channels and cannabinoid receptors are deputed to the regulation of sensory, homeostatic, and inflammatory events in the human organism. Therefore, their modulation promises to have relevant applications in important therapeutic areas such as inflammation, pain, and cancer. This review sum...

journal_title：Planta medica

authors： Rigano D,Formisano C,Taglialatela-Scafati O

更新日期：2016-06-01 00:00:00

abstract：:An Alkanna orientalis leaf and flower extract inhibited the growth of Staphylococcus aureus, a pathogen that causes an estimated 478 000 hospitalizations in the US annually. Bioassay-guided fractionation of A. orientalis resulted in isolation of the flavonoid sarothrin (5,7,4'-trihydroxy-3,6,8-trimethoxyflavone), whic...

journal_title：Planta medica

authors： Bame JR,Graf TN,Junio HA,Bussey RO 3rd,Jarmusch SA,El-Elimat T,Falkinham JO 3rd,Oberlies NH,Cech RA,Cech NB

更新日期：2013-03-01 00:00:00

abstract：:In the present study, we attempted to compare quercetin methyl ethers and to look for the structure-activity relationships, which may be helpful for synthesizing more active compounds for the treatment of asthma. Four present and two previously studied quercetin methyl ethers concentration-dependently relaxed histamin...

journal_title：Planta medica

authors： Ko WC,Kuo SW,Sheu JR,Lin CH,Tzeng SH,Chen CM

更新日期：1999-04-01 00:00:00

abstract：:A MeOH extract prepared from culture of an actinomycete Streptomyces sp. HZP-2216E isolated from marine green algae Ulva pertusa was found to significantly inhibit proliferation of human glioma cells. Two different media were applied to culture this marine actinomycete, which produced two new compounds of 23-O-butyryl...

journal_title：Planta medica

authors： Zhang Z,Chen L,Zhang X,Liang Y,Anjum K,Chen L,Lian XY

更新日期：2017-12-01 00:00:00

abstract：:Bamboo, Phyllostachys edulis produces well known edible shoots in Asia. Immunostimulating anticomplementary (complement activating) substances have been recognized as a characteristic biological response modifier (BRM). In the present study, we isolated and characterized three anticomplementary beta-glucans (BS-BGA, B...

journal_title：Planta medica

authors： Kweon MH,Hwang HJ,Sung HC

更新日期：2003-01-01 00:00:00

abstract：:Flavonolignan compounds have been isolated from the fruits of SILYBUM MARIANUM subsp. ANATOLICUM and kaempferol 3-sulphate and other flavonoid compounds have been isolated from the aerial parts and were identified. The flavonoid sulphate derivatives are shown to be present in SILYBUM genus for the first time. ...

journal_title：Planta medica

authors： Meriçli AH

更新日期：1988-02-01 00:00:00

abstract：:Reduced estrogen levels occurring during menopause in woman are accompanied by a variety of disorders, e. g., hot flushes, depressions, osteoporosis, increase of body weight, and reduced movement drive. In this study we investigated the combined effects of physical activity, estradiol substitution, and a phytoestrogen...

journal_title：Planta medica

authors： Hertrampf T,Degen GH,Kaid AA,Laudenbach-Leschowsky U,Seibel J,Di Virgilio AL,Diel P

更新日期：2006-05-01 00:00:00

abstract：:Three new sauchinone analogues, sauchinones B-D (1-3), together with sauchinone (4), were isolated from the aerial part of Saururus chinensis. Structures of the new compounds were determined by extensive spectroscopic data as well as X-ray analysis. Compounds 3 and 4 inhibited nitric oxide production in lipopolysaccha...

journal_title：Planta medica

authors： Gao X,He J,Wu XD,Peng LY,Dong LB,Deng X,Li Y,Cheng X,Zhao QS

更新日期：2013-12-01 00:00:00

abstract：:The inhibitory action of the major constituent of Sebastiania schottiana (Euphorbiaceae), 2-hydroxy-4,6-dimethoxyacetophenone (xanthoxyline) on contractions induced by agonists and electrical stimulation of smooth and cardiac muscle preparations was analysed. Xanthoxyline (30 to 300 microM) inhibited contractions of t...

journal_title：Planta medica

authors： Calixto JB,Miguel OG,Yunes RA,Rae GA

更新日期：1990-02-01 00:00:00

abstract：:The indole alkaloid content of RAUWOLFIA SERPENTINA roots from regenerated plants (from stem-and root-callus) was compared with the parental stock. Although the total alkaloid content seems to be slightly higher in the roots from regenerated plants, HPLC-analysis of individual alkaloids indicated that the contents of ...

journal_title：Planta medica

authors： Ruyter CM,Akram M,Illahi I,Stöckigt J

更新日期：1991-08-01 00:00:00

abstract：:We present the application of the generative topographic map algorithm to visualize the chemical space populated by natural products and synthetic drugs. Generative topographic maps may be used for nonlinear dimensionality reduction and probabilistic modeling. For compound mapping, we represented the molecules by two-...

journal_title：Planta medica

authors： Miyao T,Reker D,Schneider P,Funatsu K,Schneider G

更新日期：2015-04-01 00:00:00

abstract：:The species Ageratina pichinchensis (Asteraceae) has been used for a long time in Mexican traditional medicine for the treatment of different skin conditions and injuries. In this study, the healing capacity of the plant extracts obtained was evaluated and, in order to understand the mechanism of healing, we also anal...

journal_title：Planta medica

authors： Romero-Cerecero O,Zamilpa-Álvarez A,Ramos-Mora A,Alonso-Cortés D,Jiménez-Ferrer JE,Huerta-Reyes ME,Tortoriello J

更新日期：2011-07-01 00:00:00

abstract：:A pyrolytic gaschromatographic process was developed for the routine assay of both cyclodextrin inclusion complexes, and for the differentiation of the mechanical mixture of the same oil with beta-cyclodextrin. The method is a direct assay of low material demand. ...

journal_title：Planta medica

authors： Pobozsny K,Kernóczi L,Tétényi P,Héthelyi I,Szejtli J

更新日期：1981-07-01 00:00:00

abstract：:The crude extract (IPA) of the plant Ipomoea pes-caprae (L.) R. Br. showed an inhibitory effect on prostaglandin synthesis in vitro. Bioassay-guided separation of the extract led to the isolation of four active compounds: 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone (1), (-)-mellein (2), eugenol (3), and 4-vinyl-guai...

journal_title：Planta medica

authors： Pongprayoon U,Baeckström P,Jacobsson U,Lindström M,Bohlin L

更新日期：1991-12-01 00:00:00

abstract：:The traditional analgesic and antipyretic Ethiopian drug "Dingetegna" is made of dried root material of Taverniera abyssinica A. Rich (Leguminosae). In a screening for nematicidal natural products, "Dingetegna" extracts showed strong nematicidal activities towards C. elegans. In the following, medicarpin and 4-hydroxy...

journal_title：Planta medica

authors： Stadler M,Dagne E,Anke H

更新日期：1994-12-01 00:00:00

abstract：:Tissue callus cultures originating from CHELIDONIUM MAJUS L. seeds were established on Gamborg B5, Murashige-Skoog (MS), and Schenk-Hildebrandt (SH) media. In all experimental conditions, calli accumulated a complex pattern of isoquinoline derivatives. The highest values, both in growth and in sanguinarine production,...

journal_title：Planta medica

authors： Colombo ML,Tomé F

更新日期：1991-10-01 00:00:00

abstract：:A microdilution technique was developed for the assessment of in vitro cytotoxicity against KB cells derived from a human epidermoid carcinoma of the nasopharynx. The test was used to determine the cytotoxicity of a series of quassinoids, isolated from Brucea javanica, and which have previously been shown to demonstra...

journal_title：Planta medica

authors： Anderson MM,O'Neill MJ,Phillipson JD,Warhurst DC

更新日期：1991-02-01 00:00:00

abstract：:The gamma-amino butyric acid (GABA) type A (GABA(A)) receptor represents a crucial target for clinical agents in the treatment of anxiety and insomnia. Using the two-microelectrode voltage clamp technique on recombinant α₁β₂γ(2S) GABA (A) receptors, effusol (1) and dehydroeffusol (2) were isolated in a bioactivity-gui...

journal_title：Planta medica

authors： Singhuber J,Baburin I,Khom S,Zehl M,Urban E,Hering S,Kopp B

更新日期：2012-03-01 00:00:00

abstract：:Flavonoids, important components of human diet, have been claimed to possess a significant antiplatelet potential, in particular due to their effects on the arachidonic acid cascade. Due to variable and incomplete results, this study was aimed at delivering a detailed analysis of the effects of 29 structurally relevan...

journal_title：Planta medica

authors： Karlíčková J,Říha M,Filipský T,Macáková K,Hrdina R,Mladěnka P

更新日期：2016-01-01 00:00:00

abstract：:Nano-encapsulation of several natural products has become an important tool in enhancing the bioavailability of some modern drugs against many diseases. Pelargonidin is an anthocyanidin found in many fruits and vegetables. Pelargonidin is loaded with poly-lactide-co-glycolic-acid, a non-toxic biodegradable polymer, to...

journal_title：Planta medica

authors： Samadder A,Tarafdar D,Abraham SK,Ghosh K,Khuda-Bukhsh AR

更新日期：2017-03-01 00:00:00

abstract：:Ten flavonoid glycosides were identified in flowers of HETEROTHECA INULOIDES ("Mexican Arnica"). Their structures were established by spectral data (UV, (1)H-NMR, (13)C-NMR, mass) and total acid hydrolysis as kaempferol 3-beta-glucoside, 3-beta-galactoside, 3-beta-rutinoside, 3-beta-robinobioside, quercetin 3-beta-glu...

journal_title：Planta medica

authors： Jerga C,Merfort I,Willuhn G

更新日期：1990-08-01 00:00:00

abstract：:A gas-chromatographical method is described on which seven pyrrolizidine alkaloids (Fuchsisenecionine, Senecionine, Senecivernine, Senkirkine, Retrorsine, O (7)-Angelylheliotridine and Heliotrine) are determinated in a qualitative way and their ratio of concentration in Senecio fuchsii, vernalis, inaequidens and ovire...

journal_title：Planta medica

authors： Wiedenfeld H,Pastewka U,Stengl P,Röder E

更新日期：1981-02-01 00:00:00

abstract：:From Polygonum hydropiper L., a C13-norisoprenoid glucoside was isolated and its absolute configuration was established to be (6S,9S)-roseoside (1) by spectroscopic evidence and X-ray crystallographic analysis of its acetate derivative (2). In addition, the stereostructure of roseoside from Canthium subcordatum was re...

journal_title：Planta medica

authors： Murai Y,Kashimura S,Tamezawa S,Hashimoto T,Takaoka S,Asakawa Y,Kiguchi K,Murai F,Tagawa M

更新日期：2001-07-01 00:00:00

abstract：:For quantitative determination of grayanotoxin I (1) in plant material, a GC/MS method was developed after trimethylsilyl derivatisation of the analytes. Forskolin (5) was used as an internal standard for quantification. ICH-compliant method validation indicated sufficient specificity, precision, quantitation (15 µg/m...

journal_title：Planta medica

authors： Lechtenberg M,Dierks F,Sendker J,Louis A,Schepker H,Hensel A

更新日期：2014-10-01 00:00:00

abstract：:In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and sikokianin C ( 2) with IC (50) values 0.54 ...

journal_title：Planta medica

authors： Nunome S,Ishiyama A,Kobayashi M,Otoguro K,Kiyohara H,Yamada H,Omura S

更新日期：2004-01-01 00:00:00

abstract：:The roots of HAPLOPAPPUS FREEMONTII afforded in addition to the known 8-oxo-beta-cyperone two further derivatives. The structures were elucidated by highfield (1)H-NMR spectroscopy. ...

journal_title：Planta medica

authors： Jakupovic J,Boeker R,King RM

更新日期：1986-10-01 00:00:00

abstract：:The roots of Cryptolepis sanguinolenta have been investigated for their chemical composition since 1931 but so far no studies on the leaves have been reported although they are used in traditional medicine in Guinea-Bissau. Two new alkaloids identified as cryptolepinoic acid (1) and methyl cryptolepinoate (2) and the ...

journal_title：Planta medica

authors： Paulo A,Gomes ET,Steele J,Warhurst DC,Houghton PJ

更新日期：2000-02-01 00:00:00