Extracts from Rhododendron ferrugineum do not exhibit grayanotoxin I: an analytical survey on grayanotoxin I within the genus Rhododendron.


:For quantitative determination of grayanotoxin I (1) in plant material, a GC/MS method was developed after trimethylsilyl derivatisation of the analytes. Forskolin (5) was used as an internal standard for quantification. ICH-compliant method validation indicated sufficient specificity, precision, quantitation (15 µg/mL) and detection (5 µg/mL) limits. Regression analysis showed that a non-linear (polynomial) model was preferable to a linear one. For isolation of grayanotoxin I reference material from Rhododendron ponticum leaves, an efficient two-step fast centrifugal partition chromatography isolation protocol is described. A survey of 17 different plant species from the genus Rhododendron revealed high grayanotoxin I content for R. catawbiense, R. ponticum, R. degronianum subsp. yakushimanum, R. × sochadzeae, R. moupinense, R. galactinum, and R. mucronatum var. ripense. The content of this compound in leaf material from R. ponticum decreased rapidly during drying process. Grayanotoxin I was not detected in different batches of fresh leaves and fruits from R. ferrugineum. In contrast to the claims of German health authorities, this traditionally used herb therefore cannot be evaluated as toxic due to the presence of grayanotoxin I.


Planta Med


Planta medica


Lechtenberg M,Dierks F,Sendker J,Louis A,Schepker H,Hensel A




Has Abstract


2014-10-01 00:00:00












  • Studies on hernandiaceae VI. Lignans and alkaloids of Hernandia guianensis.

    abstract::The lignoidic and alkaloidal content of the leaves, stem barks and root barks of H. GUIANENSIS has been studied; two aryltetrahydronaphthalenes, two dibenzylbutyrolactones and nine alkaloids are isolated. All components are identified by means of the spectral analysis. Eight alkaloids are aporphines and nor-aporphines...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Richomme P,Lavault M,Jacquemin H,Bruneton J

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  • Studies on the Turnover of Cardenolides in Convallaria majalis.

    abstract::In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2) and the subsequent...

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    authors: Schrutka-Rechtenstamm R,Kopp B,Löffelhardt W

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  • New aspects of DNA-based authentication of Chinese medicinal plants by molecular biological techniques.

    abstract::DNA technology provides a powerful tool to complement chemical analyses for authentication of Chinese medicinal plants and to ensure that herbal materials are not contaminated with ineffective or potentially harmful substitutes or adulterants. In the last two decades molecular biotechnology has provided sophisticated ...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Heubl G

    更新日期:2010-12-01 00:00:00

  • Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats.

    abstract::ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...

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    authors: Anukunwithaya T,Tantisira MH,Tantisira B,Khemawoot P

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  • Labdane diterpenoids and shikimic acid derivatives from Araucaria cunninghamii.

    abstract::Four new (1-4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ENT-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ENT-19-( E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid N-butyl ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chen J,Chen JJ,Yang LQ,Hua L,Gao K

    更新日期:2011-03-01 00:00:00

  • A new specific BACE-1 inhibitor from the stembark extract of Vitis vinifera.

    abstract::A new resveratrol dimer, (+)-vitisinol E (1) which demonstrated inhibitory activity on BACE-1 (beta-site APP-cleaving enzyme 1) in vitro, was isolated from the stembark extract of Vitis vinifera (Vitaceae) together with four known resveratrol oligomers, (+)-epsilon-viniferin (2), (+)-ampelopsin A (3), (+)-vitisin A (4...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Choi YH,Yoo MY,Choi CW,Cha MR,Yon GH,Kwon DY,Kim YS,Park WK,Ryu SY

    更新日期:2009-04-01 00:00:00

  • Inhibition of thrombin activity by selected natural products in comparison to neutrophil elastase.

    abstract::Enzymatic thrombin activity is significantly inhibited only by a few selected natural phenolic compounds (myricetin, rosmarinic acid, caffeic acid phenethyl ester) but more strongly by unsaturated fatty acids like erucic acid and oleic acids. Compared to the inhibitory potential against neutrophil elastase, thrombin a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Melzig MF,Henke K

    更新日期:2005-08-01 00:00:00

  • Telemetry as a tool to measure sedative effects of a valerian root extract and its single constituents in mice.

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    pub_type: 杂志文章


    authors: Chow NK,Fretz M,Hamburger M,Butterweck V

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  • Hypoglycemic activity of olive leaf.

    abstract::The hypoglycemic activity of olive leaf was studied. Maximum hypoglycemic activity was obtained from samples collected in the winter months, especially in February. One of the compounds responsible for this activity was oleuropeoside, which showed activity at a dose of 16 mg/kg. This compound also demonstrated antidia...

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  • Quantitative determination of ophiopogonin d by liquid chromatography/electrospray ionization mass spectrometry and its pharmacokinetics in rat.

    abstract::A sensitive and rapid liquid chromatography-mass spectrometric method for the determination of ophiopogonin D in rat plasma was developed and validated. Chromatographic separation was performed on a C (18) column using a step gradient program with the mobile phase of 0.5 mmol/L ammonium chloride solution and acetonitr...

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    authors: Hay AE,Guilet D,Morel C,Larcher G,Macherel D,Le Ray AM,Litaudon M,Richomme P

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    abstract::The special extract of Cimicifuga racemosa (CR) BNO 1055 was shown to have bone protective effects without exerting estrogenic effects in the uterus or mammary gland. Whether the effects of CR BNO 1055 would be exerted in other organs that also express estrogen receptors (ERs) but in which the effects of estrogens and...

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    authors: Seidlova-Wuttke D,Jarry H,Wuttke W

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  • Chemical composition, acute toxicity, and antinociceptive activity of the essential oil of a plant breeding cultivar of basil (Ocimum basilicum L.).

    abstract::Ocimum basilicum L. is an aromatic herb used in Brazil to treat illnesses such as respiratory and rheumatic problems, vomiting, and pain. In the present study, the chemical composition, acute toxicity, and antinociceptive effects of the essential oil (EO) of the cultivar "Maria Bonita" obtained from O. basilicum L. PI...

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    authors: Venâncio AM,Onofre AS,Lira AF,Alves PB,Blank AF,Antoniolli AR,Marchioro M,Estevam Cdos S,de Araujo BS

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  • Plasma pharmacokinetics and tissue distribution of arctiin and its main metabolite in rats by HPLC-UV and LC-MS.

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    journal_title:Planta medica

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    authors: Qiu F,Xia H,Zhang T,Di X,Qu G,Yao X

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    abstract::The aim of this study was to evaluate the effects of 7-epiclusianone (7-epi) on specific virulence attributes of Streptococcus mutans in vitro and on development of dental caries in vivo. 7-Epi was obtained and purified from fruits of Rheedia brasiliensis. We investigated its influence on surface-adsorbed glucosyltran...

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    journal_title:Planta medica

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    authors: Liu H,Chou GX,Wang JM,Ji LL,Wang ZT

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  • Activity of quinones from teak (Tectona grandis) on fungal cell wall stress.

    abstract::Teak ( Tectona grandis L.f., Verbenaceae) sawdust extract inhibited the growth of Aspergillus niger. Centrifugal partition chromatography was used to isolate the active compounds. By (1)H-NMR the active compounds were identified as deoxylapachol and tectoquinone. Two A. niger transgenic strains which show induction of...

    journal_title:Planta medica

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  • Evaluation of the anti-trypanosomal activity of tyropeptin A.

    abstract::The natural compound tyropeptin A, a new peptidyl aldehyde proteasome inhibitor, was tested for its trypanocidal activity in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. The concentrations of tyropeptin A required to reduce the growth rate by 50 % and to kill all cells were 10 and 100 times low...

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  • In vitro effect of valepotriates isolated from Valeriana glechomifolia on rat P-type ATPases.

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  • Effect of Culture Conditions on DOPA Accumulation in a Callus Culture of Stizolobium hassjoo.

    abstract::Effects of passage of subculture and several culture conditions, nutritional, hormonal and light conditions on 3,4-dihydroxyphenylalanine (DOPA) content were examined in callus of STIZOLOBIUM HASSJOO P IPER and T RACY. The favourable conditions for DOPA accumulation were found to be suboptimal conditions for growth, i...

    journal_title:Planta medica

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  • Studies on the endocrine effects of the contents of Cimicifuga racemosa:.

    abstract::Endocrine activity can be demonstrated for components of the rhizome of CIMICIFUGA RACEMOSA using ovariectomized rats as experimental model. A selective reduction of the serum concentration of the pituitary luteinizing hormone (LH) takes place upon application of an extract. The active principle can be concentrated by...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jarry H,Harnischfeger G

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  • Inhibition of Tau aggregation by three Aspergillus nidulans secondary metabolites: 2,ω-dihydroxyemodin, asperthecin, and asperbenzaldehyde.

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    journal_title:Planta medica

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    authors: Paranjape SR,Chiang YM,Sanchez JF,Entwistle R,Wang CC,Oakley BR,Gamblin TC

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  • New camptothecin and ellagic acid analogues from the root bark of Camptotheca acuminata.

    abstract::As part of a study on chemical constituents of Camptotheca species, one new natural camptothecin analogue (2), two new alkaloids (3, 4), one new ellagic acid analogue (5), and 19 known compounds (1, 6-23) have been isolated from the root bark, stem bark, fruits, and leaves of Camptotheca acuminata Decaisne. The struct...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhang Z,Li S,Zhang S,Liang C,Gorenstein D,Beasley RS

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  • Antiherpetic activities of sulfated polysaccharides from green algae.

    abstract::In order to evaluate the potency of novel antiviral drugs, 11 natural sulfated polysaccharides (SPs) from 10 green algae ( Enteromorpha compressa, Monostroma nitidum, Caulerpa brachypus, C. okamurai, C. scapelliformis, Chaetomorpha crassa, C. spiralis, Codium adhaerens, C. fragille, and C. latum) and 4 synthetic sulfa...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee JB,Hayashi K,Maeda M,Hayashi T

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  • Steroidal saponins from Tribulus terrestris.

    abstract::Three new steroidal saponins were isolated from the fruits of Tribulus terrestris, and their structures were elucidated as (25R,S)-5 alpha-spirostane-12-one-3 beta-ol-3-O-beta-xylopyranosyl(1-->2)- [beta-xylopyranosyl(1-->3)]-beta-glucopyranosyl(1-->4)-[alpha-rhamno- pyranosyl(1-->2)]-beta-galactopyranoside; 26-O-beta...

    journal_title:Planta medica

    pub_type: 信件


    authors: Cai L,Wu Y,Zhang J,Pei F,Xu Y,Xie S,Xu D

    更新日期:2001-03-01 00:00:00

  • MicroRNAs as New Bioactive Components in Medicinal Plants.

    abstract::Herbal medicine has been used to treat diseases for centuries; however, the biological active components and the mechanistic understanding of actions of plant-derived drugs are permanently discussed. MicroRNAs are a class of small, non-coding RNAs that play crucial roles as regulators of gene expression. In recent yea...

    journal_title:Planta medica

    pub_type: 杂志文章,评审


    authors: Xie W,Weng A,Melzig MF

    更新日期:2016-08-01 00:00:00

  • New lycopodium alkaloids from Huperzia serrata.

    abstract::Three new lycopodium alkaloids, 11alpha-hydroxyphlegmariurine B (2), 7alpha-hydroxyphlegmariurine B (3) and 7alpha,11alpha-dihydroxyphlegmariurine B (4) along with a known compound, phlegmariurine B (1), were isolated from the herb Huperzia serrata. The structures of the above compounds were elucidated based on spectr...

    journal_title:Planta medica

    pub_type: 信件


    authors: Tan CH,Wang BD,Jiang SH,Zhu DY

    更新日期:2002-02-01 00:00:00

  • Alterations in sulfur amino acid metabolism in mice treated with silymarin: a novel mechanism of its action involved in enhancement of the antioxidant defense in liver.

    abstract::It has been known that silymarin exhibits protective activity against oxidative liver injury induced by various hepatotoxicants, but the underlying mechanism of its beneficial action remains unclear. We determined the alterations in sulfur-containing amino acid metabolism induced by silymarin in association with its e...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kwon DY,Jung YS,Kim SJ,Kim YS,Choi DW,Kim YC

    更新日期:2013-08-01 00:00:00

  • Chemical and pharmacological investigation of the stem bark of Synadenium grantii.

    abstract::Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, su...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Munhoz AC,Minozzo BR,Cruz LS,Oliveira TL,Machado WM,Pereira AV,Fernandes D,Manente FA,Vellosa JC,Nepel A,Barison A,Beltrame FL

    更新日期:2014-04-01 00:00:00