The Constitution and Configuration of Isocaryophyllen-13-al.

abstract：:Malaria treatment and control have become increasingly difficult because of the spread of drug-resistant strains of Plasmodium falciparum and Plasmodium vivax. Thus, there is a continuous need to develop new combination therapies such as artemisinin-based combination therapies (ACTs) to contrast the emergence of resis...

journal_title：Planta medica

authors： Sannella AR,Karioti A,Orsini S,Scalone A,Gradoni L,Messori L,Severini C,Bilia AR

更新日期：2019-08-01 00:00:00

abstract：:Leaves and stem barks of S. scheffleri Gilg afforded eight dihydroindole alkaloids. Four tertiary monomers (O-methyl Na-acetylstrychnosplendine, Na-acetylstrychnosplendine, strychnobrasiline and strychnofendlerine) have been isolated from leaf material while stem barks yielded one tertiary monomer (desacetylisoretulin...

journal_title：Planta medica

authors： Caprasse M,Angenot L

更新日期：1981-08-01 00:00:00

abstract：:This paper studies the effect of different concentrations of ethephon on the levels of the sesquiterpene, nootkatone, and of the flavanones, naringin and narirutin, in grapefruit fruits. The results show that nootkatone synthesis and/or accumulation was stimulated by all the concentrations of ethephon assayed, while t...

journal_title：Planta medica

authors： Puig DG,Pérez ML,Fuster MD,Ortuño A,Sabater F,Porras I,Lidón AG,Del Río JA

更新日期：1995-06-01 00:00:00

abstract：:Phytochemical investigation of the ethyl acetate extract from the aerial parts of Eryngium triquetrum Vahl resulted in the isolation of new polyacetylenes, triquetridiol (6) and trans-epoxy-triquetrol (7a/7b, diastereomeric mixture), and the lignan demethoxy carolignan Z (8a/8b, erythro/threo pair), together with a se...

journal_title：Planta medica

authors： Bouzergoune F,Ciavatta ML,Bitam F,Carbone M,Aberkane MC,Gavagnin M

更新日期：2016-11-01 00:00:00

abstract：:Evodiamine, a major alkaloidal principle of Evodia fruits (Evodia rutaecarpa, Rutaceae), showed vanilloid receptor agonistic activities comparable to capsaicin. The Chinese literature refers to Evodia fruits as a "hot nature" herb. In spite of the similarities in the actions of evodiamine and capsaicin in vitro, evodi...

journal_title：Planta medica

authors： Kobayashi Y,Nakano Y,Kizaki M,Hoshikuma K,Yokoo Y,Kamiya T

更新日期：2001-10-01 00:00:00

abstract：:Two new bisiridoid glucosides, radiatoside B and C, together with the known compounds mussaenosidic acid and geniposidic acid, were isolated from the aerial parts of ARGYLIA RADIATA. The structures of the new compounds were established by spectroscopic methods. ...

journal_title：Planta medica

authors： Bianco A,Passacantilli P,Righi G,Nicoletti M,Serafini M,Garbarino JA,Gambaro V,Chamy MC

更新日期：1987-08-01 00:00:00

abstract：:Khat (Catha edulis Forsk.) is a perennial shrub whose young leaves are chewed for their psychostimulating and anorectic properties. The main active principles of khat are believed to be the phenylpropylamino alkaloids, primarily (-)-cathinone [(S)-α-aminopropiophenone], (+)-cathine [(1S)(2S)-norpseudoephedrine], and (...

journal_title：Planta medica

authors： Krizevski R,Bar E,Dudai N,Levy A,Lewinsohn E,Sitrit Y,Ben-Shabat S

更新日期：2012-05-01 00:00:00

abstract：:The purpose of this study was to investigate dermal pharmacokinetics of terpinen-4-ol in rats following topical administration of plai oil derived from the rhizomes of Zingiber cassumunar Roxb. Unbound terpinen-4-ol concentrations in dermal tissue were measured by microdialysis. The dermal pharmacokinetic study of ter...

journal_title：Planta medica

authors： Chooluck K,Singh RP,Sathirakul K,Derendorf H

更新日期：2012-11-01 00:00:00

abstract：:Nano-encapsulation of several natural products has become an important tool in enhancing the bioavailability of some modern drugs against many diseases. Pelargonidin is an anthocyanidin found in many fruits and vegetables. Pelargonidin is loaded with poly-lactide-co-glycolic-acid, a non-toxic biodegradable polymer, to...

journal_title：Planta medica

authors： Samadder A,Tarafdar D,Abraham SK,Ghosh K,Khuda-Bukhsh AR

更新日期：2017-03-01 00:00:00

abstract：:The chemical analyses of two Cynara species: C. humilis and C.cornigera revealed various combinations of flavones, flavonols, flavanones, coumarins, phenolic acids, and an aurone. All the identified constituents are reported for the first time from the two species, while the presence of the aurone is reported for the ...

journal_title：Planta medica

authors： Chinou I,Harvala C

更新日期：1997-10-01 00:00:00

abstract：:Oxygen radical injury and lipid peroxidation have been suggested as major causes of atherosclerosis, cancer, liver disease, and the aging process. More specifically, oxidative modification of low density lipoprotein (LDL) has been recognized as an important process of atherosclerosis. In this study, we determined the ...

journal_title：Planta medica

authors： Ide N,Nelson AB,Lau BH

更新日期：1997-06-01 00:00:00

abstract：:This study evaluated the susceptibility of oral pathogenic microorganisms Candida albicans, Streptococcus mutans, Staphylococcus aureus, and Aggregatibacter actinomycetemcomitans to Brazilian medicinal plant extracts of Schinus terebinthifolius (aroeira), Croton campestris (velame), Lafoensia pacari (pacari), Centauri...

journal_title：Planta medica

authors： Pereira EM,Gomes RT,Freire NR,Aguiar EG,Brandão Md,Santos VR

更新日期：2011-03-01 00:00:00

abstract：:The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were...

journal_title：Planta medica

authors： Li L,Nie J,Shen Z,Wu W,Chen Z,Hao X

更新日期：2001-03-01 00:00:00

abstract：:Several synthetic aromatase inhibitors are currently in clinical use for the treatment of postmenopausal women with hormone-receptor positive breast cancer. However, these treatments may lead to untoward side effects and so the search for new aromatase inhibitors continues, especially those for which the activity is p...

journal_title：Planta medica

authors： Balunas MJ,Kinghorn AD

更新日期：2010-08-01 00:00:00

abstract：:The culture medium of Beauveria amorpha Hohn. exhibited strong radical scavenging properties. Activity-directed fractionation assisted by a radical scavenging assay on TLC afforded two active compounds which were identified as 6-methyl-2,4-dihydroxyphenyl 4-O-methyl-beta-D-glucopyranoside (1) and (-)-terredionol (2). ...

journal_title：Planta medica

authors： Hu F,Schmidt K,Stoyanova S,Zengzhi L,Gräfe U,Hamburger M

更新日期：2002-01-01 00:00:00

abstract：:O-Methyl (1), O-ethyl (2), and O-butyl (3) 4-[(α-L-rhamnosyloxy) benzyl] thiocarbamate (E), along with 4-(α-L-rhamnosyloxy) benzyl isothiocyanate (4) have been isolated from the aerial parts of Moringa peregrina. The compounds were tested for in vitro activity against Trypanosoma brucei rhodesiense and cytotoxicity in...

journal_title：Planta medica

authors： Ayyari M,Salehi P,Ebrahimi SN,Zimmermann S,Portmann L,Krauth-Siegel RL,Kaiser M,Brun R,Rezadoost H,Rezazadeh S,Hamburger M

更新日期：2014-01-01 00:00:00

abstract：:The hypoglycemic activity of olive leaf was studied. Maximum hypoglycemic activity was obtained from samples collected in the winter months, especially in February. One of the compounds responsible for this activity was oleuropeoside, which showed activity at a dose of 16 mg/kg. This compound also demonstrated antidia...

journal_title：Planta medica

authors： Gonzalez M,Zarzuelo A,Gamez MJ,Utrilla MP,Jimenez J,Osuna I

更新日期：1992-12-01 00:00:00

abstract：:Tuberculosis is the main cause of death from a single infectious agent. Globally, according to the World Health Organization, in 2018, there were an estimated 1.2 million tuberculosis deaths. Moreover, there is a continuous appearance of drug-resistant strains. Thus, development of new antituberculosis medicines shoul...

journal_title：Planta medica

authors： Guzmán-Gutiérrez SL,Silva-Miranda M,Krengel F,Huerta-Salazar E,León-Santiago M,Díaz-Cantón JK,Espitia Pinzón C,Reyes-Chilpa R

更新日期：2020-05-11 00:00:00

abstract：:Antioxidants such as vitamin E may act differently on skin cells depending on the age of the skin and the level of oxidative damage induced. The effects of alpha-tocopherol (ATF) on H(2)O(2)-induced DNA damage and telomere shortening of normal human skin fibroblast cells derived from young and old individual donors we...

journal_title：Planta medica

authors： Makpol S,Zainuddin A,Rahim NA,Yusof YA,Ngah WZ

更新日期：2010-06-01 00:00:00

abstract：:Our investigations into the stability of tincture preparations of milk thistle fruit [ Silybum marianum L. Gaertn. (Asteraceae)] have led to the characterization of a new flavonolignan 4-(4-hydroxy-3-methoxyphenyl)-7-[(2 R,3 R)-3,5,7-trihydroxy-4-oxochroman-2-yl]-1-oxo-1,3,3a,4,5,7a-hexahydro-2-benzofuran-5-carboxylic...

journal_title：Planta medica

authors： MacKinnon SL,Hodder M,Craft C,Simmons-Boyce J

更新日期：2007-09-01 00:00:00

abstract：:Using exhaustive chromatographic separation we have isolated (-)-tigloyl-deangeloyl-gomisin F as a novel dibenzocyclooctadiene lignan from schisandra chinensis. With the help of HPLC, we further isolated (+)-schisandrin, (+)-deoxyschisandrin, (+)-γ-schisandrin, (-)-gomisin J, (+)-gomisin A, (-)-gomisin N, (-)-tigloyl-...

journal_title：Planta medica

authors： Smejkal K,Slapetová T,Krmenčík P,Babula P,Dall'Acqua S,Innocenti G,Vančo J,Casarin E,Carrara M,Kalvarová K,Dvorská M,Slanina J,Kramářová E,Julínek O,Urbanová M

更新日期：2010-10-01 00:00:00

abstract：:Sungucine and isosungucine are two bisindole alkaloids isolated from the roots of the African plant Strychnos icaja Baillon. They both exhibit antiplasmodial activities but also show cytotoxic effects against human cancer cell lines. In order to elucidate their mechanism of action, we have investigated the interaction...

journal_title：Planta medica

authors： Lansiaux A,Bailly C,Houssier C,Colson P,De Pauw-Gillet MC,Frédérich M,Tits M,Angenot L

更新日期：2002-07-01 00:00:00

abstract：:The antisecretory activity of Guazuma ulmifolia bark was examined in rabbit distal colon mounted in an Ussing chamber. Chloride secretion was stimulated by cholera toxin and prostaglandin E2 (PGE2). Guazuma ulmifolia extract (GUE) completely inhibited cholera toxin-induced secretion if the extract was added to the muc...

journal_title：Planta medica

authors： Hör M,Rimpler H,Heinrich M

更新日期：1995-06-01 00:00:00

abstract：:Despite the huge diversity of antibacterial compounds, bacterial resistance to first-choice antibiotics has been drastically increasing. Moreover, the association between multiresistant microorganisms and nosocomial infections highlight the problem, and the urgent need for solutions. Natural resources have been exploi...

journal_title：Planta medica

authors： Alves MJ,Ferreira IC,Dias J,Teixeira V,Martins A,Pintado M

更新日期：2012-11-01 00:00:00

abstract：:Phytochemical analysis of the leaves of BOLDOA PURPURASCENS Cav. led to isolation of four flavone glycosides, three of which are new compounds. Their structures have been determined by mass spectrometry and by 1 D and 2 D NMR analysis, i. e., 4',5-dihydroxy-6,7-methylenedioxyflavonol 3- O-alpha- L-rhamnopyranosyl-(1--...

journal_title：Planta medica

authors： Mosquera DM,Kilonda A,Toppet S,Compernolle F,Dehaen W,François IE,Cammue BP,Apers S,Pieters L,Cuéllar AC

更新日期：2008-10-01 00:00:00

abstract：:Citral, 3,7-dimethyl-2,6-octadien-1-al, a key component of the lemon-scented essential oils extracted from several herbal plants such as lemon grass (Cymbopogon citratus), melissa (Melissa officinalis), verbena (Verbena officinalis) is used as a food additive and as a fragrance in cosmetics. In this study, we investig...

journal_title：Planta medica

authors： Dudai N,Weinstein Y,Krup M,Rabinski T,Ofir R

更新日期：2005-05-01 00:00:00

abstract：:Silybum marianum Gaertn. (Milk thistle) has been used since ancient times for the relief of liver diseases characterized by intense oxidative stress such as inflammatory liver disease and cirrhosis. As oxidative stress by hyperglycemia is involved in micro- and macrovascular complications of type 2 diabetes, our aim w...

journal_title：Planta medica

authors： Palomino OM,Gouveia NM,Ramos S,Martín MA,Goya L

更新日期：2017-01-01 00:00:00

abstract：:From the leaves of DIGITALIS LANATA Ehrh. two new Cardenolides have been found and structurally elucidated as Digoxigenin-3-O-beta- D-digitoxosido-beta- D-digitoxosido-beta- D-xyloside bei TLC and spectroscopic methods. ...

journal_title：Planta medica

authors： Krüger D,Wichtl M

更新日期：1984-06-01 00:00:00

abstract：:Two new coumaryloxy triterpenoids, neriucoumaric and isoneriucoumaric acids, have been isolated from fresh, undried and uncrushed leaves of NERIUM OLEANDER and their structures established as 3beta-hydroxy-2alpha-cis- P-coumaryloxy-urs-12-en-28-oic acid and 3beta-hydroxy-2alpha- TRANS- P-coumaryloxy-urs-12-en-28-oic a...

journal_title：Planta medica

authors： Siddiqui S,Siddiqui BS,Hafeez F,Begum S

更新日期：1987-10-01 00:00:00

abstract：:The hydroalcoholic extract (HE) obtained from stems and leaves of Hedyosmum brasiliense, given i.p., produced significant inhibition of acetic acid-induced abdominal constriction in mice, with a mean ID50 of 12.7 mg/kg. This effect installed rapidly (0.5 h) and lasted for up to 2 h. Given orally up to 1000 mg/kg, the ...

journal_title：Planta medica

authors： Trentin AP,Santos AR,Guedes A,Pizzolatti MG,Yunes RA,Calixto JB

更新日期：1999-08-01 00:00:00