Abstract:
:Several synthetic aromatase inhibitors are currently in clinical use for the treatment of postmenopausal women with hormone-receptor positive breast cancer. However, these treatments may lead to untoward side effects and so the search for new aromatase inhibitors continues, especially those for which the activity is promoter-specific, targeting the breast-specific promoters I.3 and II. Recently, numerous natural compounds have been found to inhibit aromatase in noncellular, cellular, and IN VIVO studies. These investigations, covering the last two years, as well as additional studies that have focused on the evaluation of natural compounds as promoter-specific aromatase inhibitors or as aromatase inducers, are described in this review.
journal_name
Planta Medjournal_title
Planta medicaauthors
Balunas MJ,Kinghorn ADdoi
10.1055/s-0030-1250169subject
Has Abstractpub_date
2010-08-01 00:00:00pages
1087-93issue
11eissn
0032-0943issn
1439-0221journal_volume
76pub_type
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