Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production.

Abstract:

:We have isolated five furanocoumarins, byakangelicin, phellopterin, imperatorin, isoimperatorin, and oxypeucedanin methanolate, from the roots of Angelica dahurica (Umbelliferae) and prepared five semi-synthesized compounds by the partial reduction of each isolated furanocoumarin, and the effects of these compounds on lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2 ) production in rat peritoneal macrophages were examined. Among these compounds, imperatorin showed the most potent inhibitory activity on the LPS-induced PGE2 production. It also inhibited the LPS-induced expressions of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES). These findings suggest that the inhibitory effect of furanocoumarins on the LPS-induced PGE2 production is due to the inhibition of the expression of COX-2 and mPGES.

journal_name

Planta Med

journal_title

Planta medica

authors

Ban HS,Lim SS,Suzuki K,Jung SH,Lee S,Lee YS,Shin KH,Ohuchi K

doi

10.1055/s-2003-39702

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

408-12

issue

5

eissn

0032-0943

issn

1439-0221

journal_volume

69

pub_type

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