Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production.


:We have isolated five furanocoumarins, byakangelicin, phellopterin, imperatorin, isoimperatorin, and oxypeucedanin methanolate, from the roots of Angelica dahurica (Umbelliferae) and prepared five semi-synthesized compounds by the partial reduction of each isolated furanocoumarin, and the effects of these compounds on lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2 ) production in rat peritoneal macrophages were examined. Among these compounds, imperatorin showed the most potent inhibitory activity on the LPS-induced PGE2 production. It also inhibited the LPS-induced expressions of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES). These findings suggest that the inhibitory effect of furanocoumarins on the LPS-induced PGE2 production is due to the inhibition of the expression of COX-2 and mPGES.


Planta Med


Planta medica


Ban HS,Lim SS,Suzuki K,Jung SH,Lee S,Lee YS,Shin KH,Ohuchi K




Has Abstract


2003-05-01 00:00:00












  • A new epoxyflavanone from tephrosia hamiltonii1.

    abstract::A phytochemical study of the whole plant of TEPHROSIA HAMILTONII afforded a new flavonoid, characterised as 5, 7-dimethoxy-8-(2, 3-epoxy-3-methylbutyl)-flavanone, along with other known compounds. ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Falak AH,Shoeb A

    更新日期:1987-04-01 00:00:00

  • Minor Alkaloids of Corydalis bulbosa, Structure of Bulbodione.

    abstract::As a result of the reinvestigation of the alkaloid content of CORYDALIS BULBOSA (L.) DC. (Papaveraceae), growing in Bulgaria, a new 8,11-dioxoaporphine alkaloid, named bulbodione, together with dihydrosanguinarine, dehydroglaucine, (+/-)-sinactine, glaucinone and bicucullinine were isolated. These six alkaloids had no...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kiryakov HG,Iskrenova ES

    更新日期:1984-04-01 00:00:00

  • Six New neo-Clerodane Diterpenoids from Aerial Parts of Scutellaria barbata and Their Cytotoxic Activities.

    abstract::Six new neo-clerodane diterpenoids (1: -6: ), scutebatas X - Z, A1-C1, along with twelve known ones (7: -18: ) were obtained via the phytochemical investigation of the aerial parts of Scutellaria barbata. Their structures were established by detailed spectroscopic analysis. The absolute configurations of 1: and 2: , a...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yang GC,Hu JH,Li BL,Liu H,Wang JY,Sun LX

    更新日期:2018-11-01 00:00:00

  • Chemical Study on the Alkaloids of Corydalis hsuchowensis.

    abstract::Ten alkaloids were isolated from the bulb of CORYDALIS HSUCHOWENSIS W. Y. Lian nov. ined. Among them nine alkaloids are known, identified as (-)-stylopine ( 1), cheilanthifoline ( 2), (+)-adlumidine ( 3), (+)-bicuculline ( 4), sibiricine ( 5), humosine A ( 6), (+)-bulbocapnine ( 7), (-)-scoulerine ( 8), and protopine ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Zhou JY,Tong XJ,Lian WY,Fang QC

    更新日期:1991-04-01 00:00:00

  • NIR Spectroscopy of Actaea racemosa L. rhizome - En Route to Fast and Low-Cost Quality Assessment.

    abstract::Rhizomes of Actaea racemosa L. (formerly Cimicifuga racemosa) gained increasing interest as a plant-derived drug due to its hormone-like activity and the absence of estrogenic activity. According to the Current Good Manufacturing Practices guidelines and pharmacopeial standards, quality assessment of herbal starting m...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bittner M,Krähmer A,Schenk R,Springer A,Gudi G,Melzig MF

    更新日期:2017-08-01 00:00:00

  • Protective effects of gastrodin on lead-induced synaptic plasticity deficits in rat hippocampus.

    abstract::Lead is a well-known toxin in the environment that causes severe damage to the nervous system. Gastrodin is the main bioactive component of Tian ma ( GASTRODIA ELATA Bl.), which is a traditional herbal medicine widely used in eastern Asia. Increasing lines of evidence show that gastrodin has diverse effects, especiall...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yong W,Xing TR,Wang S,Chen L,Hu P,Li CC,Wang HL,Wang M,Chen JT,Ruan DY

    更新日期:2009-08-01 00:00:00

  • Stimulatory effect of paeoniflorin on adenosine release to increase the glucose uptake into white adipocytes of Wistar rat.

    abstract::The present study investigated the role of adenosine in the stimulatory action of paeoniflorin on in vitro glucose transport. Paeoniflorin increased the uptake of a radiolabeled, non-metabolizable glucose derivative into isolated white adipocytes of Wistar rat in a concentration-dependent manner and this action was ab...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Tang LM,Liu IM,Cheng JT

    更新日期:2003-04-01 00:00:00

  • (3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethyl-perhydro-1,4-oxazine-2,5-dione: an apoptosis-inducer from the fruiting bodies of Isaria japonica.

    abstract::(3R,6R)-4-methyl-6-(1-methylethyl)-3-phenylmethylperhydro-1,4-oxazine-2,5-dione (1) was isolated from the fruiting bodies of Isaria japonica as an apoptosis-inducing agent. The complete structural assignment of the compound was accomplished on the basis of spectroscopic methods and chemical transformations. Compound 1...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Oh H,Kim T,Oh GS,Pae HO,Hong KH,Chai KY,Kwon TO,Chung HT,Lee HS

    更新日期:2002-04-01 00:00:00

  • Labdane diterpenoids and shikimic acid derivatives from Araucaria cunninghamii.

    abstract::Four new (1-4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ENT-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ENT-19-( E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid N-butyl ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chen J,Chen JJ,Yang LQ,Hua L,Gao K

    更新日期:2011-03-01 00:00:00

  • Gingerols of Zingiber officinale enhance glucose uptake by increasing cell surface GLUT4 in cultured L6 myotubes.

    abstract::In this study we investigate the active constituents of the rhizome of Zingiber officinale, Roscoe (ginger) and determine their activity on glucose uptake in cultured L6 myotubes and the molecular mechanism underlying this action. Freeze-dried ginger powder was extracted with ethyl acetate (1 kg/3 L) to give the total...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Li Y,Tran VH,Duke CC,Roufogalis BD

    更新日期:2012-09-01 00:00:00

  • A new cytotoxic agent from solid-state fermented mycelium of Antrodia camphorata.

    abstract::Antroquinonol ( 1), an ubiquinone derivative, was isolated from the solid-state fermented mycelium of Antrodia camphorata (Polyporaceae, Aphyllophorales), a parasitic fungus indigenous to Taiwan. The structure of compound 1 was elucidated by the analysis of their spectroscopic data. Its cytotoxic activities were evalu...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee TH,Lee CK,Tsou WL,Liu SY,Kuo MT,Wen WC

    更新日期:2007-10-01 00:00:00

  • [Immunologically active glycoproteins of Baptisia tinctoria].

    abstract::Chromatographically purified fractions of aqueous-ethanolic extracts from Baptisia tinctoria roots contained a strong lymphocyte DNA synthesis-stimulating activity. Electrophoretic analysis of these fractions revealed four distinct protein bands with molecular masses of P1 = 58 kD; P4 = 31 kD; P5 = 26 kD; and P6 = 14 ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Beuscher N,Scheit KH,Bodinet C,Kopanski L

    更新日期:1989-08-01 00:00:00

  • Analgesic, antipyretic and anti-inflammatory properties of Euphorbia hirta.

    abstract::Lyophilised aqueous extract of Euphorbia hirta L. (Euphorbiaceae) has been evaluated for analgesic, antipyretic and anti-inflammatory properties in mice and rats, in order to complete its activity profile, after the confirmation of the existence of a central depressant activity particularly expressed by a strong sedat...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lanhers MC,Fleurentin J,Dorfman P,Mortier F,Pelt JM

    更新日期:1991-06-01 00:00:00

  • Stimulatory effects of ingenols from Euphorbia kansui on the expression of macrophage Fc receptor.

    abstract::Immune complex binding to macrophages was enhanced by treatment with an E. kansui extract. Systematic fractionation of the extract led to the characterization of 3-O-(2'E,4'Z-decadienoyl)- and 3-O-(2,3-dimethylbutyryl)-13- O-n-dodecanoyl-13-hydroxyingenol as the active principles. Immune complex binding to macrophages...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Matsumoto T,Cyong JC,Yamada H

    更新日期:1992-06-01 00:00:00

  • Inhibition of chemiluminescence in human PMNs by monocyclic phenolic acids and flavonoids.

    abstract::Flavonoids are metabolized in vivo to monocyclic phenolic acids. We investigated whether 18 phenolic acids of the benzoic, phenylacetic, phenylpropanoic or cinnamic series-known or potential metabolites of flavonoids-inhibit reactive oxygen species (ROS) released by human polymorphonuclear neutrophils (PMNs). Chemilum...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Limasset B,Ojasoo T,le Doucen C,Doré JC

    更新日期:1999-02-01 00:00:00

  • Antiviral Activity of a Arisaema Tortuosum Leaf Extract and Some of its Constituents against Herpes Simplex Virus Type 2.

    abstract::Infections caused by HSV-2 are a public health concern worldwide, and there is still a great demand for the discovery of novel anti-herpes virus agents effective against strains resistant to current antiviral agents. In this context, medicinal plants represent an alternative source of active compounds for developing e...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Rittà M,Marengo A,Civra A,Lembo D,Cagliero C,Kant K,Lal UR,Rubiolo P,Ghosh M,Donalisio M

    更新日期:2020-03-01 00:00:00

  • Separations of flavan-3-ols and dimeric proanthocyanidins by capillary electrophoresis.

    abstract::Micellar electrokinetic capillary chromatography (MECC), using a phosphate buffer pH 7.0 and sodium dodecyl sulfate as the surfactant, was found suitable for the separation of structurally similar flavan-3-ols and related dimeric proanthocyanidins. A total of 20 substances has been tested, 17 of which were successfull...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kreimeyer J,Petereit F,Nahrstedt A

    更新日期:1998-02-01 00:00:00

  • Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo.

    abstract::The aim of this study was to investigate the protective effect of (S)-bakuchiol isolated from the seed of Psoralea corylifolia, on liver injury. Primary rat hepatocyte intoxication was induced by tert-butyl hydroperoxide (tBH), carbon tetrachloride (CCl4) or D-galactosamine (D-GalN). Liver injury was induced by either...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Park EJ,Zhao YZ,Kim YC,Sohn DH

    更新日期:2005-06-01 00:00:00

  • Activities and Prevalence of Proteobacteria Members Colonizing Echinacea purpurea Fully Account for Macrophage Activation Exhibited by Extracts of This Botanical.

    abstract::Evidence supports the theory that bacterial communities colonizing Echinacea purpurea contribute to the innate immune enhancing activity of this botanical. Previously, we reported that only about half of the variation in in vitro monocyte stimulating activity exhibited by E. purpurea extracts could be accounted for by...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Haron MH,Tyler HL,Pugh ND,Moraes RM,Maddox VL,Jackson CR,Pasco DS

    更新日期:2016-09-01 00:00:00

  • Anti-inflammatory effect of kamebakaurin in in vivo animal models.

    abstract::We have identified kamebakaurin as an inhibitor of NF-KB and elucidated its molecular mechanism as a specific inhibitor in the DNA-binding activity of the p50 subunit of NF-KB. Here, we describe its anti-inflammatory activity in in vitro and in vivo models. Kamebakaurin dose-dependently inhibited not only the expressi...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee JH,Choi JK,Noh MS,Hwang BY,Hong YS,Lee JJ

    更新日期:2004-06-01 00:00:00

  • Flavonol glycoside gallate and ferulate esters from Persicaria lapathifolia as inhibitors of superoxide production in human monocytes stimulated by unopsonized zymosan.

    abstract::Aerial parts of Persicaria lapathifolia S.F. Gray (Polygonaceae) exhibited an inhibitory effect on superoxide production in unopsonized zymosan-stimulated human monocytes. Two known compounds, quercetin 3-O-beta-(2"-galloyl)-glucopyranoside and quercetin 3-O-beta-(2"-galloyl)-rhamnopyranoside, and a new compound, quer...

    journal_title:Planta medica

    pub_type: 信件


    authors: Kim Y,Jang DS,Park SH,Yun J,Min BK,Min KR,Lee HK

    更新日期:2000-02-01 00:00:00

  • Flow Cytometric Analysis of Cellular Berberine Contents in High- and Low-Producing Cell Lines of Coptis japonica Obtained by Repeated Selection.

    abstract::Cell lines that were highly productive for berberine were selected by repeated cloning of small cell aggregates. The berberine content of the highest-producing cell line increased after 4 clonings to 10% dw in comparison to the 3% dw found for the parent line, and the berberine yield was about 1,500 mg/1/14 days. Ther...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Hara Y,Yamagata H,Morimoto T,Hiratsuka J,Yoshioka T,Fujita Y,Yamada Y

    更新日期:1989-04-01 00:00:00

  • Nematicidal activities of two phytoalexins from Taverniera abyssinica.

    abstract::The traditional analgesic and antipyretic Ethiopian drug "Dingetegna" is made of dried root material of Taverniera abyssinica A. Rich (Leguminosae). In a screening for nematicidal natural products, "Dingetegna" extracts showed strong nematicidal activities towards C. elegans. In the following, medicarpin and 4-hydroxy...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Stadler M,Dagne E,Anke H

    更新日期:1994-12-01 00:00:00

  • Inhibition of HCV replicon cell growth by 2-arylbenzofuran derivatives isolated from Mori Cortex Radicis.

    abstract::Medicinal herbs are increasingly used in the search for safe and efficient drug candidates for hepatitis C virus infection. In this study, we have investigated the anti-HCV effect of compounds from Mori Cortex Radicis. During a screening for extracts with anti-HCV affinity from medicinal plants (173 species), the meth...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lee HY,Yum JH,Rho YK,Oh SJ,Choi HS,Chang HB,Choi DH,Leem MJ,Choi EJ,Ryu JM,Hwang SB

    更新日期:2007-11-01 00:00:00

  • Composition and antimicrobial activity of the essential oil of Peumus boldus leaves.

    abstract::The composition and the antimicrobial activity of the essential oil from the leaves of Peumus boldus is investigated. Analyses of the oil obtained by hydrodistillation were carried out by GC and GC-MS using columns of two different stationary phases. Fractionation of the essential oil by column chromatography on silic...

    journal_title:Planta medica

    pub_type: 信件


    authors: Vila R,Valenzuela L,Bello H,Cañigueral S,Montes M,Adzet T

    更新日期:1999-03-01 00:00:00

  • Gastric cytoprotective anti-ulcerogenic actions of hydroxychalcones in rats.

    abstract::The preventive effects of hydroxychalcone derivatives on ulcer formation induced by severe necrotizing agents such as 60% ethanol in 150 mM HCl (HCl-ethanol) and 0.2 N NaOH in rats were examined. Among the compounds tested, 2',4'-dihydroxychalcone gave the strongest activity in both experimental models and protected t...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yamamoto K,Kakegawa H,Ueda H,Matsumoto H,Sudo T,Miki T,Satoh T

    更新日期:1992-10-01 00:00:00

  • The hypoglycemic effect of Nigella sativa oil is mediated by extrapancreatic actions.

    abstract::A plant mixture containing extracts of Nigella sativa possesses blood glucose lowering effects, but the direct antidiabetic effect of Nigella sativa is not yet established. Therefore, the effect of Nigella sativa oil (NSO) on blood glucose concentrations was studied in streptozotocin diabetic rats. In addition, the ef...

    journal_title:Planta medica

    pub_type: 信件


    authors: El-Dakhakhny M,Mady N,Lembert N,Ammon HP

    更新日期:2002-05-01 00:00:00

  • Studies on the Turnover of Cardenolides in Convallaria majalis.

    abstract::In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2) and the subsequent...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Schrutka-Rechtenstamm R,Kopp B,Löffelhardt W

    更新日期:1985-10-01 00:00:00

  • Berberine inhibits cell growth and mediates caspase-independent cell death in human pancreatic cancer cells.

    abstract::Pancreatic cancer is one of the most aggressive human malignancies with an increasing incidence worldwide. In addition to the poor survival rates, combinations using gemcitabine as a backbone have failed to show any benefit beyond monotherapy. These facts underscore an urgent need for novel therapeutic options and mot...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pinto-Garcia L,Efferth T,Torres A,Hoheisel JD,Youns M

    更新日期:2010-08-01 00:00:00

  • New lignans and cytotoxic constituents from Wikstroemia lanceolata.

    abstract::Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known se...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Lin RW,Tsai IL,Duh CY,Lee KH,Chen IS

    更新日期:2004-03-01 00:00:00