Inhibitory effects of furanocoumarins isolated from the roots of Angelica dahurica on prostaglandin E2 production.

Abstract:

:We have isolated five furanocoumarins, byakangelicin, phellopterin, imperatorin, isoimperatorin, and oxypeucedanin methanolate, from the roots of Angelica dahurica (Umbelliferae) and prepared five semi-synthesized compounds by the partial reduction of each isolated furanocoumarin, and the effects of these compounds on lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2 ) production in rat peritoneal macrophages were examined. Among these compounds, imperatorin showed the most potent inhibitory activity on the LPS-induced PGE2 production. It also inhibited the LPS-induced expressions of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES). These findings suggest that the inhibitory effect of furanocoumarins on the LPS-induced PGE2 production is due to the inhibition of the expression of COX-2 and mPGES.

journal_name

Planta Med

journal_title

Planta medica

authors

Ban HS,Lim SS,Suzuki K,Jung SH,Lee S,Lee YS,Shin KH,Ohuchi K

doi

10.1055/s-2003-39702

subject

Has Abstract

pub_date

2003-05-01 00:00:00

pages

408-12

issue

5

eissn

0032-0943

issn

1439-0221

journal_volume

69

pub_type

杂志文章
  • In vitro and in vivo studies of trypanocidal activity of dietary isothiocyanates.

    abstract::Six dietary isothiocyanates, allyl-isothiocyanate, benzyl-isothiocyanate, phenylethyl-isothiocyanate, sulforaphane, erucin, and iberin, were tested for their trypanocidal activities in vitro using culture-adapted bloodstream forms of Trypanosoma brucei. All isothiocyanates showed a dose-dependent effect on the growth ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0033-1360262

    authors: Steverding D,Michaels S,Read KD

    更新日期:2014-02-01 00:00:00

  • New lignans and cytotoxic constituents from Wikstroemia lanceolata.

    abstract::Two new lignans, (-)-aptosimon ( 1) and (-)-diasesamin-di-gamma-lactone ( 2), together with twenty-two known compounds, have been isolated from the stems and roots of Wikstroemia lanceolata. The structures of the new compounds were determined through spectral analyses. The proton and carbon assignments of the known se...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2004-815540

    authors: Lin RW,Tsai IL,Duh CY,Lee KH,Chen IS

    更新日期:2004-03-01 00:00:00

  • Inheritance of Biomass Yield and Tropane Alkaloid Content in Hyoscyamus muticus.

    abstract::The nature of gene action for biomass yield and tropane alkaloid content was ascertained through diallel analysis in Egyptian henbane, HYOSCYAMUS MUTICUS L. Dominance variation was preponderant over additive genetic variance, dominance being in the overdominance range for both traits. On an overall basis, recessive al...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-961395

    authors: Misra HO,Sharma JR,Lal RK

    更新日期:1992-02-01 00:00:00

  • Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways.

    abstract::The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0043-113447

    authors: Yang X,Gao X,Cao Y,Guo Q,Li S,Zhu Z,Zhao Y,Tu P,Chai X

    更新日期:2018-01-01 00:00:00

  • Identification of Melissa officinalis Subspecies by DNA Fingerprinting.

    abstract::The random amplified polymorphic DNA analysis (RAPD) is a method to study genetic variability within and between populations and species on the basis of the amplification of anonymous fragments from genomic DNA templates by means of polymerase chain reaction (PCR). We applied RAPD analysis in order to distinguish medi...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960447

    authors: Wolf HT,van den Berg T,Czygan FC,Mosandl A,Winckler T,Zündorf I,Dingermann T

    更新日期:1999-02-01 00:00:00

  • Prediction of the Passive Intestinal Absorption of Medicinal Plant Extract Constituents with the Parallel Artificial Membrane Permeability Assay (PAMPA).

    abstract::At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-101247

    authors: Petit C,Bujard A,Skalicka-Woźniak K,Cretton S,Houriet J,Christen P,Carrupt PA,Wolfender JL

    更新日期:2016-03-01 00:00:00

  • [A comparative study of the effects of selection and environmental factors on alkaloid accumulation in strains of Choisya ternata].

    abstract::The accumulation of two dihydrofuroquinoline alkaloids has been studied in seventeen strains of Choisya ternata (Rutaceae) initiated from the same tree. The contents of platydesminium and balfourodinium vary in heavy proportions. The effect of some factors (age of the culture, NAA or glucose concentrations of the medi...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971221

    authors: Gras M,Crèche J,Chénieux JC,Rideau M

    更新日期:1982-12-01 00:00:00

  • GABA(A) receptor modulators from the Chinese herbal drug Junci Medulla--the pith of Juncus effusus.

    abstract::The gamma-amino butyric acid (GABA) type A (GABA(A)) receptor represents a crucial target for clinical agents in the treatment of anxiety and insomnia. Using the two-microelectrode voltage clamp technique on recombinant α₁β₂γ(2S) GABA (A) receptors, effusol (1) and dehydroeffusol (2) were isolated in a bioactivity-gui...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0031-1298174

    authors: Singhuber J,Baburin I,Khom S,Zehl M,Urban E,Hering S,Kopp B

    更新日期:2012-03-01 00:00:00

  • XVIII: Eperudiendiol, Glycerides and Neolignans from Fruits of Osteophloeum platyspermum1.

    abstract::The fruits of OSTEOPHLOEUM PLATYSPERMUM (Myristicaceae) contain sitosterol, eperu-8(20),13-dien-3alpha,15-diol, glyceryl laurodimyristate, glyceryl 1,3-lauromyristate and five neolignans: dihydroguaiaretic acid, hydroxyotobain, hydroxyoxootobain, guaiacin and otobaphenol. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969620

    authors: Fo RB,de Carvalho MG,Gottlieb OR

    更新日期:1984-02-01 00:00:00

  • Four new lignans from the stems of Kadsura heteroclita.

    abstract::Two new C(18) dibenzocyclooctadiene lignans named heteroclitalignans A and B (1 and 3), one new C(19) homolignan named heteroclitalignan C(4) and one new natural product named heteroclitalignan D(2), together with the four known lignans kadsurarin (5), kadsulignan E (6), d-epigalbacin, and meso-dihydroguaiaretic acid ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-916213

    authors: Wang W,Liu J,Liu R,Xu Z,Yang M,Wang W,Liu P,Sabia G,Wang X,Guo D

    更新日期:2006-02-01 00:00:00

  • Spectral characterisation and antiplasmodial activity of bisbenzylisoquinolines from Isolona ghesquiereina.

    abstract::From stem barks of Isolona guesquiereina three known bisbenzylisoquinolines were isolated and identified as (-)-curine, chondrofoline and isochondodendrine. Structures were established mainly on the basis of comparison of their physical and spectral data with published data for them and their methylated derivatives. C...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2000-8610

    authors: Mambu L,Martin MT,Razafimahefa D,Ramanitrahasimbola D,Rasoanaivo P,Frappier F

    更新日期:2000-08-01 00:00:00

  • Antitumor activity of PEGylated nanoliposomes containing crocin in mice bearing C26 colon carcinoma.

    abstract::Crocin is a pharmacologically active component of Crocus sativus. It is an unusual water-soluble carotenoid responsible for the red color of saffron. In various studies, the anticancer effect of saffron and its constituents has been established. Polyethylene glycolated nanoliposomes with a size range up to 200 nm are ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328363

    authors: Rastgoo M,Hosseinzadeh H,Alavizadeh H,Abbasi A,Ayati Z,Jaafari MR

    更新日期:2013-04-01 00:00:00

  • [Immunologically active glycoproteins of Baptisia tinctoria].

    abstract::Chromatographically purified fractions of aqueous-ethanolic extracts from Baptisia tinctoria roots contained a strong lymphocyte DNA synthesis-stimulating activity. Electrophoretic analysis of these fractions revealed four distinct protein bands with molecular masses of P1 = 58 kD; P4 = 31 kD; P5 = 26 kD; and P6 = 14 ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962028

    authors: Beuscher N,Scheit KH,Bodinet C,Kopanski L

    更新日期:1989-08-01 00:00:00

  • Piper methysticum: enantiomeric separation of kavapyrones by high performance liquid chromatography.

    abstract::A simultaneous separation of the enantiomers of kawain, dihydrokawain, methysticin, and dihydromethysticin as well as the achiral dienolides yangonin and demethoxyyangonin was carried out on a ChiraSpher NT column. This HPLC method can be used for the investigation of the enantiomeric purity of plant material and herb...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957606

    authors: Häberlein H,Boonen G,Beck MA

    更新日期:1997-02-01 00:00:00

  • Salazinic Acid-Derived Depsidones and Diphenylethers with α-Glucosidase Inhibitory Activity from the Lichen Parmotrema dilatatum.

    abstract::Three new depsidones, parmosidones F - G (1 - 2), and 8'-O-methylsalazinic acid (3), and 3 new diphenylethers, parmetherines A - C (4 - 6), together with 2 known congeners were isolated from the whole thalli of Parmotrema dilatatum, a foliose chlorolichen. Their structures were unambiguously determined by extensive sp...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1203-0623

    authors: Devi AP,Duong TH,Ferron S,Beniddir MA,Dinh MH,Nguyen VK,Pham NK,Mac DH,Boustie J,Chavasiri W,Pogam PL

    更新日期:2020-11-01 00:00:00

  • Alkaloids from Hippeastrum equestre. Part I. Phamine, a new phenanthridone alkaloid.

    abstract::From the bulbs of Vietnamese Hippeastrum equestre Herb. (Amaryllidaceae), besides the well known alkaloids lycorine, tazettine, and hippeastrine, a new alkaloid, phamine, has been isolated. Its structure was established by spectroscopic methods. ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-959375

    authors: Döpke W,Pham LH,Gründemann E,Bartoszek M,Flatau S

    更新日期:1995-12-01 00:00:00

  • Hypoglycaemic effect of Coccinia indica: mechanism of action.

    abstract::The hypoglycaemic effect of orally administered extracts of leaves and roots of Coccinia indica has been reported earlier. The oral administration of the pectin isolated from the fruit of the above plant at a dose of 200 mg/100 g BW/day showed a significant hypoglycaemic action in normal rats. Pectins isolated from ma...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-959693

    authors: Kumar GP,Sudheesh S,Vijayalakshmi NR

    更新日期:1993-08-01 00:00:00

  • p-Terphenyl- and phenanthraquinone derivatives: an NMR study.

    abstract::(1)H- and (13)C-NMR spectral data are presented for six p-terphenylquinone derivatives (and for two monosubstituted quinones 1 and 2, used as model compounds) and for 9,10-phenanthraquinone and retenequinone. The chemical shifts were confirmed through correlation spectroscopy and NOE measurements. ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-957712

    authors: Jokela R,Lounasmaa M

    更新日期:1997-08-01 00:00:00

  • Two new 8-oxotetrahydroprotoberberine alkaloids, gusanlung A and B, from Acangelisia gusanlung.

    abstract::Two new 8-oxotetrahydroprotoberberine alkaloids, gusanlung A(1) and B(2), together with known isoquinoline alkaloids, berberine and jatrorrhizine, were isolated from the Chinese medicinal plant Acangelisia gusanlung H. S. Lo (Menispermaceae). Their structures were elucidated mainly by spectroscopic analysis. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960150

    authors: Zhang JS,Chen ZL

    更新日期:1991-10-01 00:00:00

  • Anti-inflammatory Flavanones and Flavanols from the Roots of Pongamia pinnata.

    abstract::A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 previously undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data. The absolute configurations of the compounds were assigned via analysis of the...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-0626-7356

    authors: Wen R,Lv H,Jiang Y,Tu P

    更新日期:2018-11-01 00:00:00

  • Two New Glucosides from Hypoxis obtusa: Obtuside A and Obtuside B1,5.

    abstract::From the rhizomes of HYPOXIS OBTUSA two monoglucosides having the same aglycone as hypoxoside, 1-(3',4'- dihydroxyphenyl)-5-(3'',4''-dihydroxyphenyl)-1-pen-ten-4-yne, have been obtained. By methylation followed by hydrogenation they have been transformed into the same compound, 1-(3'-methoxy-4'- O-beta- D-glucopyranos...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962019

    authors: Galeffi C,Multari G,De Vicente Y,Messana I,Nicoletti M,Marini-Bettolo GB

    更新日期:1989-06-01 00:00:00

  • Erythrinaline alkaloids and antimicrobial flavonoids from Erythrina latissima.

    abstract::The seed pods of Erythrina latissima yielded erysotrine, erysodine, syringaresinol, vanillic acid, a new erythrina alkaloid, (+)-10,11-dioxoerysotrine, which was lethal to brine shrimp and 2-(5'-hydroxy-3'-methoxy phenyl)-6-hydroxy-5-methoxybenzofuran, which showed strong antimicrobial activity against the yeast spore...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-32891

    authors: Wanjala CC,Juma BF,Bojase G,Gashe BA,Majinda RR

    更新日期:2002-07-01 00:00:00

  • Eupatoriopicrin 19-O-Linolenoate and Other Constituents from Eupatorium cannabium.

    abstract::The investigation of the roots and aerial parts of EUPATORIUM CANNABIUM afforded, in addition to the sesquiterpene lactones eupatolide, eupatoriopicrin, and eucannabinolide isolated previously, eight further lactones, three of which are new. Furthermore, in addition to known compounds, a new clerodane derivative and t...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-962665

    authors: Zdero C,Bohlmann F

    更新日期:1987-04-01 00:00:00

  • Composition and antimicrobial activity of the essential oil of Salvia ringens.

    abstract::The essential oils of Salvia ringens (samples A and B), were analyzed by means of GC and GC/MS. From the seventy-five identified constituents representing 99.82 and 99.86% of the oils, 1,8-cineole and alpha-pinene were the major components. Furthermore, sample B exhibited a very interesting antimicrobial profile after...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2001-10627

    authors: Tzakou O,Pitarokili D,Chinou IB,Harvala C

    更新日期:2001-02-01 00:00:00

  • Two new beta-carboline alkaloids from Hedyotis capitellata var. mollis.

    abstract::Two new beta-carboline alkaloids, hedyocapitelline and hedyocapitine, were isolated from Hedyotis capitellata var. mollis (Rubiaceae). Their structures were elucidated by spectroscopic data (1)H- and (13)C-NMR, MS, IR, UV). ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960861

    authors: Phuong NM,Van Sung T,Porzel A,Schmidt J,Adam G

    更新日期:1999-12-01 00:00:00

  • New sesquiterpene lactones with antibacterial activity from Vernonia fastigiata.

    abstract::Sesquiterpene lactones 1-5 were isolated for the first time from the ethyl acetate of Vernonia fastigiata (Asteraceae). Compounds 3, 4 and 5 are new, compounds 1 and 2 have been found earlier in other Vernonia species but not in V. fastigiata. ...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-957551

    authors: Roos G,Prawat H,Walter CU,Klaiber I,Vogler B,Guse JH,Kraus W

    更新日期:1998-10-01 00:00:00

  • Extracts from Pygeum africanum and other ethnobotanical species with antiandrogenic activity.

    abstract::Extracts from Pygeum africanum, Serenoa repens and Cucurbita pepo are used in the treatment of benign prostatic hyperplasia (BPH) and prostate cancer (PCa). The activity of the androgen receptor (AR) is known to control growth of the prostate. Here, we examined extracts of these plants for their antiandrogenic activit...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-946638

    authors: Schleich S,Papaioannou M,Baniahmad A,Matusch R

    更新日期:2006-07-01 00:00:00

  • 9'-Epi-3β,3'β-dimethylxestospongin C, a new macrocyclic diamine alkaloid from the Hainan sponge Neopetrosia exigua.

    abstract::A new BIS-1-oxaquinolizidine alkaloid, 9'- EPI-3 β,3' β-dimethylxestospongin C (2), and three known related analogues have been isolated from the Hainan sponge Neopetrosia exigua. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250164

    authors: Li Y,Qin S,Guo YW,Gu YC,van Soest RW

    更新日期:2011-01-01 00:00:00

  • Minor secondary metabolic products from the stem bark of Plumeria rubra Linn. displaying antimicrobial activities.

    abstract::Four new iridoids viz., plumeridoids A, B, and C and epiplumeridoid C were isolated from the stem bark of Plumeria rubra Linn. together with twenty-four known compounds viz., 1-( P-hydroxyphenyl)propan-1-one, isoplumericin, plumericin, dihydroplumericin, allamcin, fulvoplumerin, allamandin, plumieride, P- E-coumaric a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0029-1240611

    authors: Kuigoua GM,Kouam SF,Ngadjui BT,Schulz B,Green IR,Choudhary MI,Krohn K

    更新日期:2010-04-01 00:00:00

  • Taxol and related compounds in Korean native yews (Taxus cuspidata).

    abstract::The concentrations of taxol and related compounds in the bark and needles of Taxus cuspidata grown on Mt. Jiri, Mt. Sobaek, and Cheju Island, and T. cuspidata var. latifolia on Ullung Island in Korea were determined by high performance liquid chromatography (HPLC). The taxane content significantly varied with the loca...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958069

    authors: Choi MS,Kwak SS,Liu JR,Park YG,Lee MK,An NH

    更新日期:1995-06-01 00:00:00