Abstract:
:We have isolated five furanocoumarins, byakangelicin, phellopterin, imperatorin, isoimperatorin, and oxypeucedanin methanolate, from the roots of Angelica dahurica (Umbelliferae) and prepared five semi-synthesized compounds by the partial reduction of each isolated furanocoumarin, and the effects of these compounds on lipopolysaccharide (LPS)-induced prostaglandin E2 (PGE2 ) production in rat peritoneal macrophages were examined. Among these compounds, imperatorin showed the most potent inhibitory activity on the LPS-induced PGE2 production. It also inhibited the LPS-induced expressions of cyclooxygenase (COX)-2 and microsomal prostaglandin E synthase (mPGES). These findings suggest that the inhibitory effect of furanocoumarins on the LPS-induced PGE2 production is due to the inhibition of the expression of COX-2 and mPGES.
journal_name
Planta Medjournal_title
Planta medicaauthors
Ban HS,Lim SS,Suzuki K,Jung SH,Lee S,Lee YS,Shin KH,Ohuchi Kdoi
10.1055/s-2003-39702subject
Has Abstractpub_date
2003-05-01 00:00:00pages
408-12issue
5eissn
0032-0943issn
1439-0221journal_volume
69pub_type
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