LC-MS- and NMR-Guided Isolation of Monoterpene Dimers from Cultivated Thymus vulgaris Varico 3 Hybrid and Their Antityrosinase Activity.

abstract：:Five compounds representative of major structural classes of lichen polyketides, VIZ. (+)-usnic (1), salazinic (2), vulpinic (3), gyrophoric (4), and evernic acids (5), were investigated for their ability to affect cell proliferation or wound healing, two functional targets of relevance for research on cancer or tissu...

journal_title：Planta medica

authors： Burlando B,Ranzato E,Volante A,Appendino G,Pollastro F,Verotta L

更新日期：2009-05-01 00:00:00

abstract：:This study was carried out to examine the potential beneficial effect of cordycepin on the decline of testicular function induced with age. A total of 30 male Sprague-Dawley rats (twenty-four 12-month-olds and six 2-month-olds) were divided into five groups. The young control (YC) and middle-aged control (MC) groups r...

journal_title：Planta medica

authors： Sohn SH,Lee SC,Hwang SY,Kim SW,Kim IW,Ye MB,Kim SK

更新日期：2012-10-01 00:00:00

abstract：:From an extract of the whole plant of Ligularia virgaurea ssp. oligocephala, three new eremophilane sesquiterpene lactones, 10alpha-hydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (1), 6alpha,10alpha-dihydroxy-1-oxoeremophila-7(11),8(9)-dien-12,8-olide (2), 6beta,10beta-dihydroxyeremophila-7(11),8(9)-dien-12,8-olid...

journal_title：Planta medica

authors： Wu QX,Shi YP,Yang L

更新日期：2004-05-01 00:00:00

abstract：:Four new (1-4) and two known compounds (5, 6) were isolated from the aerial parts of Araucaria cunninghamii. By analysis of UV, IR, MS, and NMR, the new compounds were identified as ENT-19-(Z)-coumaroyloxylabda-8(17),13(16),14-triene (1), ENT-19-( E)-coumaroyloxylabda-8(17),13(16),14-triene (2), shikimic acid N-butyl ...

journal_title：Planta medica

authors： Chen J,Chen JJ,Yang LQ,Hua L,Gao K

更新日期：2011-03-01 00:00:00

abstract：:Indole alkaloid contents were investigated in leaves of Tabernaemontana pachysiphon (Apocynaceae) trees in the natural habitat, Shimba Hills National Reserve, Kenya. The contents of the major alkaloids apparicine, tubotaiwine, tubotaiwine- N-oxide, and isovoacangine varied with site, leaf age, leaf growth form, positi...

journal_title：Planta medica

authors： Höft M,Verpoorte R,Beck E

更新日期：1998-03-01 00:00:00

abstract：:Two new bisiridoid glucosides, radiatoside B and C, together with the known compounds mussaenosidic acid and geniposidic acid, were isolated from the aerial parts of ARGYLIA RADIATA. The structures of the new compounds were established by spectroscopic methods. ...

journal_title：Planta medica

authors： Bianco A,Passacantilli P,Righi G,Nicoletti M,Serafini M,Garbarino JA,Gambaro V,Chamy MC

更新日期：1987-08-01 00:00:00

abstract：:Two new compounds, methyl 3-chloro-6-hydroxy-2-(4-hydroxy-2-methoxy-6-methylphenoxy)-4-methoxybenzoate (1) and (2 S,5' R,E)-7-hydroxy-4,6-dimethoxy-2-(1-methoxy-3-oxo-5-methylhex-1-enyl)-benzofuran-3(2H)-one (2), together with four known compounds, griseofulvin (3), dechlorogriseofulvin (4), bostrycin (5), and deoxybo...

journal_title：Planta medica

authors： Xia X,Li Q,Li J,Shao C,Zhang J,Zhang Y,Liu X,Lin Y,Liu C,She Z

更新日期：2011-10-01 00:00:00

abstract：:Three new vermistatin derivatives, 6-demethylpenisimplicissin (1), 5'-hydroxypenisimplicissin (2), and 2''-epihydroxydihydrovermistatin (3), along with five known vermistatin analogues, methoxyvermistatin (4), vermistatin (5), 6-demethylvermistatin (6), hydroxyvermistatin (7), and penisimplicissin (8), were isolated f...

journal_title：Planta medica

authors： Liu Y,Xia G,Li H,Ma L,Ding B,Lu Y,He L,Xia X,She Z

更新日期：2014-07-01 00:00:00

abstract：:Tuberculosis, also called TB, is currently a major health hazard due to multidrug-resistant forms of bacilli. Global efforts are underway to eradicate TB using new drugs with new modes of action, higher activity, and fewer side effects in combination with vaccines. For this reason, unexplored new sources and previousl...

journal_title：Planta medica

authors： Santhosh RS,Suriyanarayanan B

更新日期：2014-01-01 00:00:00

abstract：:Soybean saponin is one of several soybean glycosides. Recently, new soybean saponins which possess the DDMP (2,5-dihydroxy-6-methyl-2,3-dihydro-4H-pyran-4-one) moiety have been detected. Soyasaponin beta g of these new soybean saponins was shown to inhibit hydrogen peroxide damage to mouse fibroblast cells. Not only t...

journal_title：Planta medica

authors： Yoshikoshi M,Yoshiki Y,Okubo K,Seto J,Sasaki Y

更新日期：1996-06-01 00:00:00

abstract：:In our investigation of in vitro antimalarial screening of medicinal herbal extracts, the n-BuOH extract from the root of Wikstroemia indica showed a potent inhibitory effect. Fractionation of the active extract led to the isolation of two biflavonoids, sikokianin B ( 1) and sikokianin C ( 2) with IC (50) values 0.54 ...

journal_title：Planta medica

authors： Nunome S,Ishiyama A,Kobayashi M,Otoguro K,Kiyohara H,Yamada H,Omura S

更新日期：2004-01-01 00:00:00

abstract：:A new minor diterpenoid alkaloid, caeruline, was isolated from DELPHINIUM CAERULEUM Jacq. ex Camb. Its structure was elucidated as 1 on the basis of spectral evidence. Along with this new compound, three known diterpenoid alkaloids were also isolated from this plant and identified as tatsiensine, delcosine, and lycoct...

journal_title：Planta medica

authors： Pan YJ,Wang R,Chen SN,Chen YZ

更新日期：1993-02-01 00:00:00

abstract：:This review describes the current status of the development of techniques combining liquid chromatography and nuclear magnetic resonance and their use in the context of natural products. HPLC-NMR methods have a rapidly growing impact on natural products research by enabling structure determination of natural products ...

journal_title：Planta medica

authors： Jaroszewski JW

更新日期：2005-08-01 00:00:00

abstract：:A study of secondary metabolites from the bark of Alnus glutinosa led to the isolation of fourteen diarylheptanoids: oregonin (1), platyphylloside (2), rubranoside A (3), rubranoside B (4), hirsutanonol (5), hirsutenone (6), hirsutanonol-5-O-β-D-glucopyranoside (7), platyphyllonol-5-O-β-D-xylopyranoside (8), aceroside...

journal_title：Planta medica

authors： Novaković M,Stanković M,Vučković I,Todorović N,Trifunović S,Tešević V,Vajs V,Milosavljević S

更新日期：2013-04-01 00:00:00

abstract：:Hyperuricemia is a clinical condition characterized by an elevated level of serum uric acid and is a key risk factor for the development of gout and metabolic disorders. The existing urate-lowering therapies are often impractical for certain patient populations, providing a rationale to explore new agents with improve...

journal_title：Planta medica

authors： Kim JK,Kim WJ,Hyun JM,Lee JS,Kwon JG,Seo C,Song MJ,Choi CW,Hong SS,Park K,Kim P,Sung H,Lee JK,Choi Y

更新日期：2017-11-01 00:00:00

abstract：:When added to suspension cultures of CATHARANTHUS ROSEUS, abscisic acid (ABA) stimulated intracellular accumulation of the indole alkaloids catharanthine and ajmalicine in both flask and 30 litre fermenter-scale systems. The response varied, and depended upon the cell line, the concentration and source of the ABA, and...

journal_title：Planta medica

authors： Smith JI,Smart NJ,Kurz WG,Misawa M

更新日期：1987-10-01 00:00:00

abstract：:(1)H- and (13)C-NMR spectral data are presented for six p-terphenylquinone derivatives (and for two monosubstituted quinones 1 and 2, used as model compounds) and for 9,10-phenanthraquinone and retenequinone. The chemical shifts were confirmed through correlation spectroscopy and NOE measurements. ...

journal_title：Planta medica

authors： Jokela R,Lounasmaa M

更新日期：1997-08-01 00:00:00

abstract：:Three new glycosides, 1,4,8-trihydroxynaphthalene-1-O-D-glucopyranosyl-(1-->6)-beta-D- xylopyranoside (1), 1,4,8-trihydroxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)-alph a-L- arabinopyranoside (2), 1-hydroxy-4-methoxynaphthalene-1-O-beta-D-glucopyranosyl-(1-->6)- alpha-L-rhamnopyranoside (3), were isolated from th...

journal_title：Planta medica

authors： Lee SW,Lee KS,Son JK

更新日期：2000-03-01 00:00:00

abstract：:Sponges are a useful source of bioactive natural products. Members of the family Mycalidae, in particular, have provided a variety of chemical structures including alkaloids, polyketides, terpene endoperoxides, peptides, and lipids. This review highlights the compounds isolated from Mycalid sponges and their associate...

journal_title：Planta medica

authors： Habener LJ,Hooper JN,Carroll AR

更新日期：2016-06-01 00:00:00

abstract：:Many compounds of plant origin have been identified that inhibit different stages in the replication cycle of human immunodeficiency virus (HIV): 1) virus adsorption: chromone alkaloids (schumannificine), isoquinoline alkaloids (michellamines), sulphated polysaccharides and polyphenolics, flavonoids, coumarins (glycoc...

journal_title：Planta medica

authors： Vlietinck AJ,De Bruyne T,Apers S,Pieters LA

更新日期：1998-03-01 00:00:00

abstract：:Bioactivity-directed separation led to the identification of four compounds, viz. denbinobin (1), 3,7-dihydroxy-2,4-dimethoxyphenanthrene (2), 3-methylgigantol (3), and erianthridin (4) from the ethanolic extract of Ephemerantha lonchophylla. Antiplatelet tests were carried out using 4 different aggregation inducers, ...

journal_title：Planta medica

authors： Chen CC,Huang YL,Teng CM

更新日期：2000-05-01 00:00:00

abstract：:Chemical investigation of the EtOH extract of Morus alba L. (Moraceae), as guided by free radical scavenging activity, furnished 5,7-dihydroxycoumarin 7-methyl ether (1), two prenylflavones, cudraflavone B (2) and cudraflavone C (3), and oxyresveratrol (4). Compounds 1 and 4 showed superoxide scavenging effects with t...

journal_title：Planta medica

authors： Oh H,Ko EK,Jun JY,Oh MH,Park SU,Kang KH,Lee HS,Kim YC

更新日期：2002-10-01 00:00:00

abstract：:The tertiary and quaternary alkaloids isolated from the stem bark, root bark and seeds of Peschiera fuchsiaefolia are reported. The tertiary alkaloid crude extract from the stem bark was tested in vitro against Plasmodium falciparum on the basis of the antimalarial use of the plant. It showed good activity against bot...

journal_title：Planta medica

authors： Federici E,Palazzino G,Nicoletti M,Galeffi C

更新日期：2000-02-01 00:00:00

abstract：:Bioassay directed fractionation of the (1:1) chloroform-methanol extract of Gentiana spathacea H.B.K (Gentianaceae) led to the isolation of gentiopicroside (gentiopricrin) (1), the major spasmolytic component of the plant. Gentiopicroside inhibited, in a concentration-dependent manner, the spontaneous contractions of ...

journal_title：Planta medica

authors： Rojas A,Bah M,Rojas JI,Gutiérrez DM

更新日期：2000-12-01 00:00:00

abstract：:The methanolic extract of the fruits of Torilis japonica showed a potent inhibition against 5 alpha-reductase activity in vitro. Bioassay-guided fractionation of the methanol extract of the fruits followed by repeated silica gel chromatography led to the isolation of an active principle and its structure was identifie...

journal_title：Planta medica

authors： Park WS,Son ED,Nam GW,Kim SH,Noh MS,Lee BG,Jang IS,Kim SE,Lee JJ,Lee CH

更新日期：2003-05-01 00:00:00

abstract：:The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were...

journal_title：Planta medica

authors： Li L,Nie J,Shen Z,Wu W,Chen Z,Hao X

更新日期：2001-03-01 00:00:00

abstract：:Myrrh is the oleo-gum resin of mainly Commiphora molmol and as a powdered substance, one compound in the traditional medicinal product Myrrhinil-Intest®, which has been used for the treatment of unspecific, inflammatory intestinal disorders. The aim of the present study was to evaluate the antispasmodic effect of myrr...

journal_title：Planta medica

authors： Vissiennon C,Goos KH,Goos O,Nieber K

更新日期：2015-01-01 00:00:00

abstract：:A callus culture of Aleurites fordii Hemsley (Euphorbiaceae) producing five galloylglucoses and an ellagitannin, geraniin, was established. The production of pentagalloylglucose was remarkably enhanced under light irradiation compared with that in the dark. Cell growth and tannin production were also greatly affected ...

journal_title：Planta medica

authors： Taniguchi S,Uechi K,Kato R,Ito H,Hatano T,Yazaki K,Yoshida T

更新日期：2002-12-01 00:00:00

abstract：:Based on the fact that Synadenium grantii is used in folk medicine for the treatment of peptic ulcers and inflammatory diseases, this work describes its chemical and pharmacological properties. Pharmacological investigation of the crude bark extract showed a high antioxidant activity over several scavenger systems, su...

journal_title：Planta medica

authors： Munhoz AC,Minozzo BR,Cruz LS,Oliveira TL,Machado WM,Pereira AV,Fernandes D,Manente FA,Vellosa JC,Nepel A,Barison A,Beltrame FL

更新日期：2014-04-01 00:00:00

abstract：:From the leaves of BLUMEA ARFAKIANA Martelli (Asteraceae), used in traditional medicine in Papua New Guinea, besides stigmasterol and beta-eudesmol, four graniline esters ( 1-4) have been isolated. Furthermore, blumealactone C ( 5), deacetylblumealactone C ( 6), and deoxyblumealactone C ( 7) have been identified. ...

journal_title：Planta medica

authors： Rücker G,Paulini G,Sakulas H,Lawong B,Goeltenboth F

更新日期：1991-06-01 00:00:00