Antispasmodic effects of myrrh due to calcium antagonistic effects in inflamed rat small intestinal preparations.

Abstract:

:Myrrh is the oleo-gum resin of mainly Commiphora molmol and as a powdered substance, one compound in the traditional medicinal product Myrrhinil-Intest®, which has been used for the treatment of unspecific, inflammatory intestinal disorders. The aim of the present study was to evaluate the antispasmodic effect of myrrh under healthy and inflamed conditions, and to evaluate a calcium-antagonistic effect as a possible mode of action. Therefore, an ethanolic myrrh extract was tested for its effects on muscle tone and acetylcholine-induced contractions in untreated and inflamed rat ileum/jejunum preparations. Inflammation was experimentally induced by 2,4,6-trinitrobenzene sulfonic acid (10 mM, 30 min). Additionally, the effect of the calcium channel agonist Bay K8644 in the presence of varying myrrh extract concentrations was examined. Myrrh extract (0.99 mg/mL) suppressed the acetylcholine-induced contraction down to 25.8 % in untreated and 15.2 % in inflamed preparations. Myrrh extract (0.15; 0.25 and 0.35 mg/mL) induced a concentration-dependent rightward shift of the Bay K8644 concentration-response curve in untreated and inflamed preparations with a significant EC50 shift. Schild analysis resulted in a pA2 value of 0.93 for untreated preparations. Increasing myrrh extract concentrations induced a concentration-dependent decrease of the agonistic maximum effect in untreated and inflamed preparations down to 15.8 % and 25.8 %, respectively, for the highest concentration leading to a pD2 value of 0.58. Myrrh extract reduced intestinal muscle tone and acetylcholine-induced contraction of untreated and inflamed ileum/jejunum preparations based on dual calcium antagonism characterized by a right shift of the agonistic dose-response curve and a depression of the maximum effect. The resulting reduction of intestinal motility and spasmolytic effects provide a rationale for the symptom treatment of intestinal disorders such as irritable bowel syndrome.

journal_name

Planta Med

journal_title

Planta medica

authors

Vissiennon C,Goos KH,Goos O,Nieber K

doi

10.1055/s-0034-1383391

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

116-22

issue

2

eissn

0032-0943

issn

1439-0221

journal_volume

81

pub_type

杂志文章
  • Ampelopsin prevents apoptosis induced by H2O2 in MT-4 lymphocytes.

    abstract::Human immunodeficiency virus (HIV) infection can result in oxidative stress through production of reactive oxygen species (ROS). Simultaneously, oxidative stress is able to activate the replication of virus and lead to the apoptosis of T lymphocytes which is the defense of the immune function. Ampelopsin, belonging to...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034317

    authors: Ye J,Guan Y,Zeng S,Liu D

    更新日期:2008-02-01 00:00:00

  • HPTLC method for the estimation of alkaloids of Cinchona officinalis stem bark and its marketed formulations.

    abstract::We report a sensitive method for the estimation of quinine (Qn), cinchonine (Cn), and cinchonidine (Cnd) and a new method based on fluorescence enhancement and detection and quantification of quinidine (Qnd) from Cinchona stem bark and its formulations, using HPTLC. Standard solutions of Qn, Qnd, Cn, and Cnd were appl...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2001-11995

    authors: Ravishankara MN,Shrivastava N,Padh H,Rajani M

    更新日期:2001-04-01 00:00:00

  • Rhealba® oat plantlet extract: evidence of protein-free content and assessment of regulatory activity on immune inflammatory mediators.

    abstract::Owing to their high content of flavonoids and saponins, plantlets of Avena sativa L. (Poaceae) are likely to possess anti-inflammatory and immunoregulatory properties of value in the treatment of atopic dermatitis (AD). With a view to its potential use in atopic subjects at risk of developing sensitisation to dietary ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0030-1250649

    authors: Mandeau A,Aries MF,Boé JF,Brenk M,Crebassa-Trigueros V,Vaissière C,Teysseyre V,Bieber T

    更新日期:2011-06-01 00:00:00

  • Antioxidant effects of 1,5-anhydro-D-fructose, a new natural sugar, in vitro.

    abstract::The antioxidant effects of 1,5-anhydro-D-fructose (1,5-AF), a unique anhydrohexulose, were studied in 1,1-diphenyl-2-picrylhydrazyl (DPPH) solution, in human cells along with lipid peroxidation of low-density lipoprotein (LDL). We have confirmed that 1,5-AF scavenges DPPH radicals directly in solution and inhibits the...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2002-20050

    authors: Yamaji K,Sarker KP,Maruyama I,Hizukuri S

    更新日期:2002-01-01 00:00:00

  • Inhibition of thrombin activity by selected natural products in comparison to neutrophil elastase.

    abstract::Enzymatic thrombin activity is significantly inhibited only by a few selected natural phenolic compounds (myricetin, rosmarinic acid, caffeic acid phenethyl ester) but more strongly by unsaturated fatty acids like erucic acid and oleic acids. Compared to the inhibitory potential against neutrophil elastase, thrombin a...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-871253

    authors: Melzig MF,Henke K

    更新日期:2005-08-01 00:00:00

  • Determination of naphthazarin derivatives in endemic Turkish Alkanna species by reversed phase high performance liquid chromatography.

    abstract::The quantification of free and total alkannins in 13 endemic Anatolian Alkanna species is described for the first time. Extraction of the samples was performed by sonication with hexane, followed by hydrolysis in 1 N NaOH. For analysis, a new HPLC method, utilizing reversed phase material (Synergi Max RP), was develop...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-967110

    authors: Pekin G,Ganzera M,Senol S,Bedir E,Korkmaz KS,Stuppner H

    更新日期:2007-03-01 00:00:00

  • Effect of abietane diterpenes from Plectranthus grandidentatus on the growth of human cancer cell lines.

    abstract::Five known abietane diterpenes, fatty acid esters of 7alpha-acyloxy-6beta-hydroxyroyleanone (1), grandidone A (2), 7alpha-acetoxy-6beta-hydroxyroyleanone (3), 6beta,7alpha-dihydroxyroyleanone (4), and coleon U (5), isolated from Plectranthus grandidentatus Gürke, were evaluated for their in vitro antiproliferative act...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2002-34407

    authors: Marques CG,Pedro M,Simões MF,Nascimento MS,Pinto MM,Rodríguez B

    更新日期:2002-09-01 00:00:00

  • Protective effect of (S)-bakuchiol from Psoralea corylifolia on rat liver injury in vitro and in vivo.

    abstract::The aim of this study was to investigate the protective effect of (S)-bakuchiol isolated from the seed of Psoralea corylifolia, on liver injury. Primary rat hepatocyte intoxication was induced by tert-butyl hydroperoxide (tBH), carbon tetrachloride (CCl4) or D-galactosamine (D-GalN). Liver injury was induced by either...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-864150

    authors: Park EJ,Zhao YZ,Kim YC,Sohn DH

    更新日期:2005-06-01 00:00:00

  • Detection of Ganoderic Acid A in Ganoderma lingzhi by an Indirect Competitive Enzyme-Linked Immunosorbent Assay.

    abstract::Ganoderma is a genus of medicinal mushroom traditionally used for treating various diseases. Ganoderic acid A is one of the major bioactive Ganoderma triterpenoids isolated from Ganoderma species. Herein, we produced a highly specific monoclonal antibody against ganoderic acid A (MAb 12 A) and developed an indirect co...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0042-104202

    authors: Sakamoto S,Kohno T,Shimizu K,Tanaka H,Morimoto S

    更新日期:2016-05-01 00:00:00

  • Neuroprotective effects in gerbils of spiramine T from Spiraea japonica var. acuta.

    abstract::The neuroprotective effects of spiramine T, an atisine-type diterpenoid alkaloid isolated from the Chinese herbal medicine Spiraea japonica var. acuta (Rosaceaee), on cerebral ischemia-reperfusion injury produced by 10-min bilateral occlusion of the common carotid arteries followed by 5-day reperfusion in gerbils were...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2001-11510

    authors: Li L,Nie J,Shen Z,Wu W,Chen Z,Hao X

    更新日期:2001-03-01 00:00:00

  • Purification and biochemical characterization of a novel allergenic protein from tatary buckwheat seeds.

    abstract::An allergenic protein from tatary buckwheat seeds, designated TBt, was purified by salting out, anion exchange chromatography and size exclusion chromatography (SEC). Analysis by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and SEC showed that the allergenic protein was composed of two subunits...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0028-1088319

    authors: Zhang X,Cui X,Li Y,Wang Z

    更新日期:2008-12-01 00:00:00

  • An anti-inflammatory ent-kaurane from the stems of Annona squamosa that inhibits various human neutrophil functions.

    abstract::We have previously shown that 11 ent-kauranes isolated from the stems of Annona squamosa exhibited immunomodulating effects in leukocytes. In this study, a cellular model using isolated human neutrophils, which are important in the pathogenesis of rheumatoid arthritis, ischemia-reperfusion injury, chronic obstructive ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2005-871234

    authors: Yeh SH,Chang FR,Wu YC,Yang YL,Zhuo SK,Hwang TL

    更新日期:2005-10-01 00:00:00

  • Taxol and related compounds in Korean native yews (Taxus cuspidata).

    abstract::The concentrations of taxol and related compounds in the bark and needles of Taxus cuspidata grown on Mt. Jiri, Mt. Sobaek, and Cheju Island, and T. cuspidata var. latifolia on Ullung Island in Korea were determined by high performance liquid chromatography (HPLC). The taxane content significantly varied with the loca...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-958069

    authors: Choi MS,Kwak SS,Liu JR,Park YG,Lee MK,An NH

    更新日期:1995-06-01 00:00:00

  • Growth of cultured human bronchiogenic epithelioid CCD-14 Br cells and dermal fibroblasts, NB1 RGB treated with ginseng tetrapeptide and its isomer.

    abstract::The configurations of the component amino acids in ginseng tetrapeptide 1 isolated from Panax ginseng were determined by HPLC with an optical resolution column and the structure of 1 was established to be H-L-Val-gamma-D-Glu-D-Arg- Gly-OH. Synthesis of the ginseng tetrapeptide, 1, and of the configuration and conjugat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-957830

    authors: Yagi A,Ishizu T,Okamura N,Noguchi S,Itoh H

    更新日期:1996-04-01 00:00:00

  • Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages.

    abstract::In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibit...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2004-815452

    authors: Abad MJ,Bermejo P,Alvarez M,Guerra JA,Silván AM,Villar AM

    更新日期:2004-01-01 00:00:00

  • Isolation and X-ray study of an anti-inflammatory active androstene steroid from Acacia nilotica.

    abstract::3beta-Acetoxy-17beta-hydroxy-androst-5-ene was isolated from aerial parts of Acacia nilotica (L.) Willd (Mimosaceae). The structure of this compound was established by spectral analysis and single crystal X-ray diffraction analysis. The steroid showed dose-dependent anti-inflammatory activity against TPA-induced mouse...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2003-38482

    authors: Chaubal R,Mujumdar AM,Puranik VG,Deshpande VH,Deshpande NR

    更新日期:2003-03-01 00:00:00

  • Small-molecule STAT3 signaling pathway modulators from Polygonum cuspidatum.

    abstract::Constitutively activated STAT3 plays a pivotal role in oncogenesis and metastasis in many human cancers, and STAT3 has been validated as a novel anticancer drug target. Thus, the identification of small molecules that modulate STAT3 activity could be of great therapeutic importance. The aim of this study was to isolat...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1315121

    authors: Liu J,Zhang Q,Chen K,Liu J,Kuang S,Chen W,Yu Q

    更新日期:2012-09-01 00:00:00

  • Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung.

    abstract::From the roots of UNCARIA TOMENTOSA six oxindol alkaloids have been isolated and identified as isopteropodin, pteropodin, mitraphyllin, isomitraphyllin, rynchophyllin and isorynchophyllin. By ion pair chromatography on HPLC a fingerprint analysis has been worked out which allowed to differentiate between various UNICA...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-969537

    authors: Wagner H,Kreutzkamp B,Jurcic K

    更新日期:1985-10-01 00:00:00

  • Adenosine, the anxiolytic-like principle of the Arillus of Euphoria longana.

    abstract::According to traditional usage, the extract of Longan Arillus was tested for its anxiolytic-like effect by application of the Vogel-type anti-conflict method in mice. The extract indicated significant activity at a dose of 2 g/kg, s.c., and results of the bioassay-oriented isolation revealed adenosine to be the active...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-1999-14055

    authors: Okuyama E,Ebihara H,Takeuchi H,Yamazaki M

    更新日期:1999-03-01 00:00:00

  • Recent development of antitumor agents from Chinese herbal medicines. Part II. High molecular compounds(3).

    abstract::High molecular compounds from Chinese herbal medicines, including ribosome-inactivating proteins and polysaccharides from both fungi and high plants have been tested for the treatment of malignant diseases. Polysaccharides possessing immunostimulating activities can be used as adjuvants in tumor treatment. The fungi c...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-2003-38494

    authors: Tang W,Hemm I,Bertram B

    更新日期:2003-03-01 00:00:00

  • Dibenzocyclooctane lignans from the stems of Schisandra wilsoniana.

    abstract::Five new dibenzocyclooctane lignans, schisanwilsonins K-O, together with eighteen known lignans were isolated from the stems of Schisandra wilsoniana. The structures of these new compounds were elucidated by spectroscopic methods, including 2D-NMR techniques. Several compounds were found to show anti-HIV and anti-HBV ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328747

    authors: Ma WH,Lu Y,Chen DF

    更新日期:2013-08-01 00:00:00

  • Differentiation of the traditional Chinese medicinal plants Euphorbia humifusa and E. maculata from adulterants by TaqMan real-time polymerase chain reaction.

    abstract::DNA sequence analysis of the rDNA internal transcribed spacer 1 (ITS1) and TaqMan real-time polymerase chain reaction were exploited for their applications in the differentiation of the traditional chinese medicinal plants euphorbia humifusa and e. maculata from three related adulterants e. hypericifolia, E. atoto and...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2008-1034305

    authors: Xue HG,Wang H,Li DZ,Xue CY,Wang QZ

    更新日期:2008-02-01 00:00:00

  • Unusual amino acids and monofluoroacetate from Dichapetalum michelsonii (Umutambasha), a toxic plant from Rwanda.

    abstract::In the course of our investigations on Umutambasha in order to identify its convulsant principles, small quantities of monofluoroacetate were observed in stem bark, leaves, and fruits of this plant newly identified as Dichapetalum michelsonii Hauman. Conclusive evidence for a monofluoroacetate presence came from its i...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0032-1328283

    authors: Esters V,Karangwa C,Tits M,Francotte P,Pirotte B,Servais AC,Fillet M,Crommen J,Robbrecht E,Minet A,Grisar T,Angenot L,Frederich M

    更新日期:2013-03-01 00:00:00

  • Hypoglycaemic activity of dioscoretine from tubers of Dioscorea dumetorum in normal and alloxan diabetic rabbits.

    abstract::Dioscoretine isolated from the aqueous fraction of the methanol extract of Dioscorea dumetorum tubers when administered intra-peritoneally to normal and alloxan diabetic rabbits produces significant hypoglycaemic effects at a dose of 20 mg/kg. The fasting blood sugar in normoglycaemic rabbits was reduced from 112 mg/1...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2006-960952

    authors: Iwu MM,Okunji CO,Ohiaeri GO,Akah P,Corley D,Tempesta MS

    更新日期:1990-06-01 00:00:00

  • [Plants from new caledonia: alkaloids of stem-bark of Hernandia cordigera].

    abstract::The alkaloidal content of of the stem barks of Hernandia cordigera has been studied and compared to that of other Hernandia species. Main alkaloids are phenolic aporphines. ...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-2007-971545

    authors: Lavault M,Debray MM,Bruneton J

    更新日期:1981-05-01 00:00:00

  • New tetrahydroprotoberberine N-oxide alkaloids and cytotoxic constituents of Corydalis tashiroi.

    abstract::Three new tetrahydroprotoberberine N-oxide alkaloids, (-)- cis-corydalmine N-oxide, (-)- trans-corydalmine N-oxide, and (-)- trans-isocorypalmine N-oxide, along with three known benzo[ C]phenanthridine alkaloids, norsanguinarine, dihydrosanguinarine, and oxysanguinarine, six known berberine alkaloids, (-)-tetrahydropa...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-1999-14090

    authors: Chen JJ,Duh CY,Chen IS

    更新日期:1999-10-01 00:00:00

  • Chemical composition and antimicrobial activity of the essential oils of Pistacia lentiscus var. chia.

    abstract::The chemical composition of the three essential oils obtained by steam distillation of the mastic gum, leaves and twigs of Pistacia lentiscus var. chia, was studied by GC/MS. Sixty nine constituents were identified from the oils. alpha-Pinene, myrcene, trans-caryophyllene and germacrene D were found to be the major co...

    journal_title:Planta medica

    pub_type: 信件

    doi:10.1055/s-2006-960856

    authors: Magiatis P,Melliou E,Skaltsounis AL,Chinou IB,Mitaku S

    更新日期:1999-12-01 00:00:00

  • Anti-Inflammatory Effects of Boldine and Reticuline Isolated from Litsea cubeba through JAK2/STAT3 and NF-κB Signaling Pathways.

    abstract::The anti-inflammatory effects of boldine and reticuline isolated from Litsea cubeba were evaluated by using xylene-induced ear edema and carrageenan-induced paw edema in mice and rats. Our results demonstrated that intragastric administration with boldine and reticuline significantly mitigated ear weight in mice and d...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/s-0043-113447

    authors: Yang X,Gao X,Cao Y,Guo Q,Li S,Zhu Z,Zhao Y,Tu P,Chai X

    更新日期:2018-01-01 00:00:00

  • Post-genome research on the biosynthesis of ergot alkaloids.

    abstract::Genome sequencing provides new opportunities and challenges for identifying genes for the biosynthesis of secondary metabolites. A putative biosynthetic gene cluster of fumigaclavine C, an ergot alkaloid of the clavine type, was identified in the genome sequence of ASPERGILLUS FUMIGATUS by a bioinformatic approach. Th...

    journal_title:Planta medica

    pub_type: 杂志文章,评审

    doi:10.1055/s-2006-947195

    authors: Li SM,Unsöld IA

    更新日期:2006-10-01 00:00:00

  • Nanoencapsulation of Plant Volatile Organic Compounds to Improve Their Biological Activities.

    abstract::Plant volatile organic compounds (volatiles) are secondary plant metabolites that play crucial roles in the reproduction, defence, and interactions with other vegetation. They have been shown to exhibit a broad range of biological properties and have been investigated for antimicrobial and anticancer activities. In ad...

    journal_title:Planta medica

    pub_type: 杂志文章

    doi:10.1055/a-1289-4505

    authors: Mun H,Townley HE

    更新日期:2020-11-11 00:00:00