Abstract:
:In the course of our investigations on Umutambasha in order to identify its convulsant principles, small quantities of monofluoroacetate were observed in stem bark, leaves, and fruits of this plant newly identified as Dichapetalum michelsonii Hauman. Conclusive evidence for a monofluoroacetate presence came from its isolation from the freeze-dried extract of stem bark. Three free unusual amino acids, named N-methyl-α-alanine, N-methyl-β-alanine, and 2,7-diaminooctan-1,8-dioic acid, described for the first time in a plant, and known trigonelline were also isolated from the stem bark of D. michelsonii. Structure elucidations were mainly achieved by spectroscopic methods (1H-NMR, 2D-NMR, MS) and by comparison with authentic references. These unusual amino acids were detected by a fast, reliable TLC analysis in all our batches of Umutambasha, suggesting that they could be used for identification purposes in case of human or livestock intoxications. Finally, EEG recordings and behavioural observations performed in mice suggested that the convulsive patterns produced by Umutambasha are the consequence of monofluoroacetate presence in D. michelsonii.
journal_name
Planta Medjournal_title
Planta medicaauthors
Esters V,Karangwa C,Tits M,Francotte P,Pirotte B,Servais AC,Fillet M,Crommen J,Robbrecht E,Minet A,Grisar T,Angenot L,Frederich Mdoi
10.1055/s-0032-1328283subject
Has Abstractpub_date
2013-03-01 00:00:00pages
334-7issue
5eissn
0032-0943issn
1439-0221journal_volume
79pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::Different oil-samples of Melissa officinalis L. were analysed by capillary GC/MS, using fused silica columns and E.I.-Mass-spectrometry. Comparing the observed mass-spectra with those of a spectral collection, 70 compounds of the oil were identified. Geranial, neral, 6-methyl-5-hepten-2-one, citronellal, geranyl-aceta...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-970028
更新日期:1982-10-01 00:00:00
abstract::Endothelial dysfunction is characterised by the low bioavailability of nitric oxide with a relevant negative impact on the nitric oxide/cGMP pathway. The loss of nitric oxide/cGMP signaling may be caused by an increased arginase activity. Plant-derived substances, especially polyphenols, are compounds that have the po...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0044-100398
更新日期:2018-03-01 00:00:00
abstract::Natural products research is increasingly turning to marine animals, plants, and microbes as source organisms. Several marine natural products are currently in preclinical and clinical evaluation, others show promising biological activities in in vitro and in vivo assays. Investigations of biological and chemical ecol...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2006-957861
更新日期:1996-06-01 00:00:00
abstract::Both borneol and menthol are bioactive substances derived from Chinese herbal medicines. In order to understand the pharmacokinetics of borneol and menthol in Qingyan drop pills, a rapid, sensitive, and simple gas chromatographic (GC) method with flame ionization detection (FID) was developed for the simultaneous dete...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1270998
更新日期:2011-09-01 00:00:00
abstract::Phytochemical investigations of the stem of Kadsura heteroclita (Roxb) Craib (Schizandraceae) resulted in the isolation and structure elucidation of six new triterpenoidal compounds named heteroclitalactones A-E (1-5) as well as heteroclic acid (6) and heteroclitalactone F (7), which was isolated for the first time fr...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916263
更新日期:2006-04-01 00:00:00
abstract::The present study aimed to investigate standardized ethanol extracts of fruit and leaves of Piper sarmentosum for their in vivo antioxidant activity in rats using a CCl (4)-induced oxidative stress model. The standardization was based on the quantification of the markers pellitorine, sarmentine and sarmentosine by hig...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1186279
更新日期:2010-03-01 00:00:00
abstract::A microdilution technique was developed for the assessment of in vitro cytotoxicity against KB cells derived from a human epidermoid carcinoma of the nasopharynx. The test was used to determine the cytotoxicity of a series of quassinoids, isolated from Brucea javanica, and which have previously been shown to demonstra...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960020
更新日期:1991-02-01 00:00:00
abstract::Protopanaxatriol and protopanaxadiol exhibit limited oral bioavailability due to the poor solubility and intestinal cytochromes P450-mediated metabolism. This study set out to develop a novel cytochromes P450 inhibitory excipient(s)-based self-microemulsion to encapsulate protopanaxatriol and protopanaxadiol so as to ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106726
更新日期:2017-03-01 00:00:00
abstract::Several synthetic aromatase inhibitors are currently in clinical use for the treatment of postmenopausal women with hormone-receptor positive breast cancer. However, these treatments may lead to untoward side effects and so the search for new aromatase inhibitors continues, especially those for which the activity is p...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0030-1250169
更新日期:2010-08-01 00:00:00
abstract::The high number of citations of the previous review on anti-HIV compounds from plants published in 1998 in Planta Medica indicates the importance of natural products research in the battle against HIV. Therefore, we have decided to write an update of our previous review paper, this time covering the time span 1998 - 2...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-2008-1081314
更新日期:2008-09-01 00:00:00
abstract::This perspective describes some commonly used animal models for the evaluation of potential chemopreventive agents in colon carcinogenesis. Special emphasis is given to the azoxymethane (AOM)/1,2-dimethylhydrazine (DMH) rat model and APCMIN mice, carrying a mutation in APC, a key gene in human carcinogenesis. In the A...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1074577
更新日期:2008-10-01 00:00:00
abstract::A quantitative analysis using (1)H-NMR (Q-NMR) has been developed for the determination of strychnine and brucine in Strychnos nux-vomica seeds and stems. The advantages of the method are that no reference alkaloids are needed for calibration curves, the quantification could be directly realized on a crude extract, st...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-818014
更新日期:2003-12-01 00:00:00
abstract::At the early drug discovery stage, the high-throughput parallel artificial membrane permeability assay is one of the most frequently used in vitro models to predict transcellular passive absorption. While thousands of new chemical entities have been screened with the parallel artificial membrane permeability assay, in...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101247
更新日期:2016-03-01 00:00:00
abstract::Geniposide, a main iridoid glucoside component of gardenia fruit, has been shown to possess anti-inflammatory activity. However, its potential use for acute lung injury (ALI) has not yet been studied. The aim of this study was to evaluate the anti-inflammatory properties of geniposide using a mouse ALI model. ALI was ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1298212
更新日期:2012-04-01 00:00:00
abstract::Halimium halimifolium (Hh) is a shrub used in Algerian folk medicine to treat gastrointestinal pain. An UHPLC-PDA-ESI/MSn method was developed to identify the metabolic profile of the traditionally used infusion (Hh-A) from the aerial parts. The structures of flavanols were confirmed by NMR analysis after the isolatio...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0953-6007
更新日期:2019-08-01 00:00:00
abstract::A methanolic extract of Commelina communis showed potent inhibitory activity against alpha-glucosidase. One pyrrolidine alkaloid, 2,5-dihydroxymethyl-3,4-dihydroxypyrrolidine (DMDP, 1) and four piperidine alkaloids, 1-deoxymannojirimycin (2), 1-deoxynojirimycin (3), alpha-homonojirimycin (4) and 7-O-beta-D-glucopyrano...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-960803
更新日期:1999-06-01 00:00:00
abstract::The aim of this study was to evaluate the effects of 7-epiclusianone (7-epi) on specific virulence attributes of Streptococcus mutans in vitro and on development of dental caries in vivo. 7-Epi was obtained and purified from fruits of Rheedia brasiliensis. We investigated its influence on surface-adsorbed glucosyltran...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250121
更新日期:2011-01-01 00:00:00
abstract::The effects of four fractions, a hexane fraction, an ethyl acetate fraction, an N-butanol fraction and a water fraction, from a water extract of Herba Visci were investigated to find the fraction, in IN VITRO experiments, with the greatest ability to inhibit the formation of osteoclast-like multinucleated cells from m...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1034283
更新日期:2008-02-01 00:00:00
abstract::Fractionation of the aqueous extract of Derris scandens stems extract using tests for eicosanoid inhibition resulted in the isolation of three isoflavonoids, genistein, its 7- O-alpha-rhamno(1-->6)-beta-glucosyl glycoside, a new compound, and two known isoprenyl derivatives 3'-gamma,gamma-dimethylallylweighteone and s...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827147
更新日期:2004-06-01 00:00:00
abstract::A new tetrahydrofuranoketone lignan (1) and two new tetrahydrofuranoketone lignan glycosides (2, 3) were isolated from the ethanol extract of the aerial part of Mananthes patentiflora. The structure elucidations of these compounds were mainly established on the basis of 1D, 2D NMR and HR-mass spectroscopic analysis. A...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0029-1185356
更新日期:2009-04-01 00:00:00
abstract::The effect of a lignan-enriched extract of the fruits of Schisandra chinensis (FS) on hepatic glutathione (GSH) status was examined in both control and carbon tetrachloride (CCl4)-treated rats. FS treatment caused a dose-dependent enhancement in hepatic GSH status, as evidenced by significant increases in hepatic GSH ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-958032
更新日期:1995-04-01 00:00:00
abstract::In the present study, we demonstrate that saucernetin-8 ( 1) and saucernetin-7 ( 2), isolated from the underground parts of Saururus chinensis (Saururaceae), exerted potent inhibitory effects on LPS-induced nitric oxide (NO) and prostaglandin E (2) (PGE (2)) production in RAW 264.7 cells. Both compounds 1 and 2, known...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-45106
更新日期:2003-10-01 00:00:00
abstract::Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1-10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NM...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0031-1280024
更新日期:2011-12-01 00:00:00
abstract::Barbaloin levels in the exudates from the leaves of 68 species of ALOE in the Kew collection have been determined by light absorption at 375 nm following separation by HPLC. The exudates from most species contained between 10-20% although a few concentrations of around 30% were found. The level in the leaf was usually...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962735
更新日期:1987-08-01 00:00:00
abstract::Crocin is a pharmacologically active component of Crocus sativus. It is an unusual water-soluble carotenoid responsible for the red color of saffron. In various studies, the anticancer effect of saffron and its constituents has been established. Polyethylene glycolated nanoliposomes with a size range up to 200 nm are ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0032-1328363
更新日期:2013-04-01 00:00:00
abstract::Six diarylheptanoids were isolated from the rhizome of Alpinia officinarum (Zingiberaceae) as inhibitors of nitric oxide (NO) production in the lipopolysaccharide-activated macrophage cell line RAW 264.7. A double bond at C-4 of the linker between two aromatic rings was found to be essential for activity. Furthermore,...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-873176
更新日期:2006-01-01 00:00:00
abstract::Transient receptor potential channels and cannabinoid receptors are deputed to the regulation of sensory, homeostatic, and inflammatory events in the human organism. Therefore, their modulation promises to have relevant applications in important therapeutic areas such as inflammation, pain, and cancer. This review sum...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0042-101352
更新日期:2016-06-01 00:00:00
abstract::The fruit of Ziziphus jujuba Mill., known as jujube or Chinese date, is commonly consumed as health supplement or herbal medicine worldwide. To study the beneficial role of jujube in enhancing hematopoietic function, we investigated its roles on the expression of erythropoietin in cultured Hep3B human hepatocellular c...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0034-1383049
更新日期:2014-11-01 00:00:00
abstract::Angelicae Sinensis Radix is commonly used in traditional Chinese medicine. Pharmacological studies show that Angelicae Sinensis Radix has clear anticoagulant activity. Therefore, in this study, the anticoagulant activity of crude Angelicae Sinensis Radix extracts was investigated by measuring the thrombin times of the...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0035-1558309
更新日期:2016-03-01 00:00:00
abstract::The chloroform extract of Valeriana officinalis led to the isolation of clionasterol-3-O-beta-D-glucopyranoside and a mixture of 6'-O-acyl-beta-D-glucosyl-clionasterols. The acyl moieties were identified as hexadecanoyl, 8 E,11 E-octadecadienoyl and 14-methylpentadecanoyl by alkaline hydrolysis followed by GC-MS analy...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-864179
更新日期:2005-10-01 00:00:00