Suppression of inducible nitric oxide synthase expression by diarylheptanoids from Alpinia officinarum.

Abstract:

:Six diarylheptanoids were isolated from the rhizome of Alpinia officinarum (Zingiberaceae) as inhibitors of nitric oxide (NO) production in the lipopolysaccharide-activated macrophage cell line RAW 264.7. A double bond at C-4 of the linker between two aromatic rings was found to be essential for activity. Furthermore, the active diarylheptanoids suppressed expression of the inducible NO synthase protein and mRNA. These results imply that the traditional use of Alpinia officinarum rhizome as anti-inflammatory drug may be explained, at least in part, by the inhibition of NO production in activated macrophages.

journal_name

Planta Med

journal_title

Planta medica

authors

Lee HJ,Kim JS,Ryu JH

doi

10.1055/s-2005-873176

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

68-71

issue

1

eissn

0032-0943

issn

1439-0221

journal_volume

72

pub_type

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