Abstract:
:Six diarylheptanoids were isolated from the rhizome of Alpinia officinarum (Zingiberaceae) as inhibitors of nitric oxide (NO) production in the lipopolysaccharide-activated macrophage cell line RAW 264.7. A double bond at C-4 of the linker between two aromatic rings was found to be essential for activity. Furthermore, the active diarylheptanoids suppressed expression of the inducible NO synthase protein and mRNA. These results imply that the traditional use of Alpinia officinarum rhizome as anti-inflammatory drug may be explained, at least in part, by the inhibition of NO production in activated macrophages.
journal_name
Planta Medjournal_title
Planta medicaauthors
Lee HJ,Kim JS,Ryu JHdoi
10.1055/s-2005-873176subject
Has Abstractpub_date
2006-01-01 00:00:00pages
68-71issue
1eissn
0032-0943issn
1439-0221journal_volume
72pub_type
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