Abstract:
:Five compounds representative of major structural classes of lichen polyketides, VIZ. (+)-usnic (1), salazinic (2), vulpinic (3), gyrophoric (4), and evernic acids (5), were investigated for their ability to affect cell proliferation or wound healing, two functional targets of relevance for research on cancer or tissue regeneration. The experiments were carried out on MM98 malignant mesothelioma cells, A431 vulvar carcinoma cells, and HaCaT keratinocytes. The NRU and CV cytotoxicity assays showed high toxicity for (+)-usnic acid, intermediate toxicity for vulpinic acid, and low toxicity for salazinic, gyrophoric and evernic acids. Scratch wounding experiments on HaCaT monolayers, in the presence of subtoxic doses of lichen compounds, showed strong wound closure effects by (+)-usnic and gyrophoric acid, an intermediate effect by vulpinic and salazinic acids, and no effect by evernic acid. A combination of (+)-usnic and gyrophoric acids gave a further increase in the wound closure rates. The results of a cell migration test correlated with the wound healing data. In conclusion, (+)-usnic acid might be a particularly interesting compound for the prevention of hyperproliferation syndromes, while (+)-usnic and gyrophoric acids qualify as interesting leads in the promotion of tissue regeneration.
journal_name
Planta Medjournal_title
Planta medicaauthors
Burlando B,Ranzato E,Volante A,Appendino G,Pollastro F,Verotta Ldoi
10.1055/s-0029-1185329subject
Has Abstractpub_date
2009-05-01 00:00:00pages
607-13issue
6eissn
0032-0943issn
1439-0221journal_volume
75pub_type
杂志文章相关文献
PLANTA MEDICA文献大全abstract::From the essential oil of Commiphora guidotti seven sesquiterpene hydrocarbons and a furanosesquiterpenoid, furanodiene, were isolated. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969896
更新日期:1983-06-01 00:00:00
abstract::Two new naphtho-pyrone glycosides, 9-[(beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]-10- hydroxy-7-methoxy-3-methyl-1H-naphtho[2,3-c]pyran-1 -one (5) and 6-[(alpha-apiofuranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]- rubrofusarin (6), together with cassiaside (3) and rubrofusarin-6-beta-gentiobioside (4)...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-962003
更新日期:1989-06-01 00:00:00
abstract::Endocrine activity can be demonstrated for components of the rhizome of CIMICIFUGA RACEMOSA using ovariectomized rats as experimental model. A selective reduction of the serum concentration of the pituitary luteinizing hormone (LH) takes place upon application of an extract. The active principle can be concentrated by...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969390
更新日期:1985-02-01 00:00:00
abstract::Shoot-tips from several genotypes of the cardenolide-producing perennial shrub Digitalis obscura L. were successfully cryopreserved using the encapsulation-dehydration technique. Precultivation on MS medium containing 0.5 M sucrose, followed by 2.5 h dehydration (final weight 30 %) induced shoot regrowth in 42 % of cr...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2001-18861
更新日期:2001-12-01 00:00:00
abstract::The solid dispersion of a poorly water-soluble Silybum marianum extract (SME) was prepared by a one-step fluid-bed coating technique depositing onto non-pareil pellets. In vitro evaluation indicated that this technique was highly efficient and reproducible producing pellets with acceptable appearance, flowability, fri...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1034294
更新日期:2008-02-01 00:00:00
abstract::Phytoestrogens are discussed as candidate substances to treat symptoms related to estrogen deficiency. In in vitro experiments, the naturally occurring flavonoid 6-(1,1-dimethylallyl)naringenin (6-DMAN) emerged as one of the most potent phytoestrogenic substances. 6-DMAN is not as well characterized as other flavonoid...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2004-827178
更新日期:2004-07-01 00:00:00
abstract::A radioimmunoassay as well as an enzyme immunoassay for the quantitation of fmol amounts of the alkaloid colchicine have been developed. The antiserum used for both assays was raised against a conjugate of colchicoside-bovine serum albumin. The crude serum was satisfactory for the performance of the radioimmunoassay. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-959413
更新日期:1994-02-01 00:00:00
abstract::The crude extract (IPA) of the plant Ipomoea pes-caprae (L.) R. Br. showed an inhibitory effect on prostaglandin synthesis in vitro. Bioassay-guided separation of the extract led to the isolation of four active compounds: 2-hydroxy-4,4,7-trimethyl-1(4H)-naphthalenone (1), (-)-mellein (2), eugenol (3), and 4-vinyl-guai...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960196
更新日期:1991-12-01 00:00:00
abstract::From the methanolic extract of the whole plants of Bidens pilosa the new beta-D-glucopyranosyloxy-3-hydroxy-6(E)-tetradecen-8, 10,12-triyne besides a known polyine has been isolated and identified mainly by IR and NMR methods. The new compound showed overgrowing action against normal and transformed human cell lines i...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-957902
更新日期:1996-08-01 00:00:00
abstract::Phytochemical analysis of the leaves of BOLDOA PURPURASCENS Cav. led to isolation of four flavone glycosides, three of which are new compounds. Their structures have been determined by mass spectrometry and by 1 D and 2 D NMR analysis, i. e., 4',5-dihydroxy-6,7-methylenedioxyflavonol 3- O-alpha- L-rhamnopyranosyl-(1--...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2008-1081332
更新日期:2008-10-01 00:00:00
abstract::This study aimed to elucidate the mechanisms of nuciferine (a main aporphine alkaloid of lotus leaf extract), which can induce relaxation in contracted tracheal rings. Under Ca2+-free and 2 mM Ca2+ conditions, we found that nuciferine had no effect on the resting muscle tone of tracheal rings. In contrast, nuciferine ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0043-118178
更新日期:2018-01-01 00:00:00
abstract::The effects of phytoestrogens on the female breast are discussed controversially. On the one hand, epidemiological and experimental data provide evidence that dietary phytoestrogens may prevent the development of breast cancer. On the other hand, in breast cancer cell lines and tumour models isoflavone phytoestrogens ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-916229
更新日期:2006-03-01 00:00:00
abstract::Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-106168
更新日期:2016-06-01 00:00:00
abstract::Leaves and stem barks of S. scheffleri Gilg afforded eight dihydroindole alkaloids. Four tertiary monomers (O-methyl Na-acetylstrychnosplendine, Na-acetylstrychnosplendine, strychnobrasiline and strychnofendlerine) have been isolated from leaf material while stem barks yielded one tertiary monomer (desacetylisoretulin...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971656
更新日期:1981-08-01 00:00:00
abstract::During the screening of antimalarial substances, the 80% EtOH extract from the outer bark of Ochna integerrima Merr. (Ochnaceae) was shown to have a good anti-malarial activity (IC50 value: 6.5 microg/mL) whereas extracts from the inner barks of O.integerrima showed no antimalarial activity. Biflavanone (1), which had...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-931569
更新日期:2006-06-01 00:00:00
abstract::Targeted isolation based on a combination of NMR and HPLC-PDA-MS of a dichloromethane extract of Thymus vulgaris Varico 3 aerial parts afforded one new p-cymene dimer, 6,3',4'-trihydroxy-5,5'-diisopropyl-2,2'-dimethylbiphenyl (1: ), together with two known p-cymene derivatives (2: and 3: ), as well as five known compo...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/a-0927-7041
更新日期:2019-08-01 00:00:00
abstract::The roots of HAPLOPAPPUS FREEMONTII afforded in addition to the known 8-oxo-beta-cyperone two further derivatives. The structures were elucidated by highfield (1)H-NMR spectroscopy. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969205
更新日期:1986-10-01 00:00:00
abstract::This paper reports the phytochemical investigation of the 50% aq. EtOH extract of Houttuynia cordata, an effective TCM and functional food in China, which led to the isolation of 17 flavonoids including four new ones. The four new compounds were flavonoid derivatives tethered with houttuynin (3-oxododecanal). Each of ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0033-1351051
更新日期:2013-12-01 00:00:00
abstract::From roots of Rubia cordifolia L. four anthraquinones are isolated: 1-hydroxy 2-methoxy anthraquinone; 1,4-dihydroxy 2-methyl 5-methoxy anthraquinone or 1,4-dihydroxy 2-methyl 8-methoxy anthraquinone; 1,3-dimethoxy 2-carboxy anthraquinone and rubiadin. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971524
更新日期:1981-12-01 00:00:00
abstract::A pyrolytic gaschromatographic process was developed for the routine assay of both cyclodextrin inclusion complexes, and for the differentiation of the mechanical mixture of the same oil with beta-cyclodextrin. The method is a direct assay of low material demand. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-971636
更新日期:1981-07-01 00:00:00
abstract::The nature of gene action for biomass yield and tropane alkaloid content was ascertained through diallel analysis in Egyptian henbane, HYOSCYAMUS MUTICUS L. Dominance variation was preponderant over additive genetic variance, dominance being in the overdominance range for both traits. On an overall basis, recessive al...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-961395
更新日期:1992-02-01 00:00:00
abstract::The present study investigated the role of adenosine in the stimulatory action of paeoniflorin on in vitro glucose transport. Paeoniflorin increased the uptake of a radiolabeled, non-metabolizable glucose derivative into isolated white adipocytes of Wistar rat in a concentration-dependent manner and this action was ab...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2003-38878
更新日期:2003-04-01 00:00:00
abstract::Two phenolic triterpenoids, pristimerol (30 µg/mL) and 8- EPI-6-deoxoblepharodol (20 µg/mL), obtained by catalytic reduction of pristimerin, exhibited bacteriostatic action against Staphylococcus epidermidis. This activity was not dependent on the inoculum size and the growth phase although it showed a stronger effect...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0030-1250500
更新日期:2011-05-01 00:00:00
abstract::25 Amaryllidaceae alkaloids belonging to different skeletal types were evaluated for their cytotoxic activity against one murine non-tumoral cell line (LMTK) and two human tumoral cell lines (Molt4 and HepG2) according to established protocols. Significant differences of activity related with the type of skeleton of t...
journal_title:Planta medica
pub_type: 信件
doi:10.1055/s-2006-958007
更新日期:1995-02-01 00:00:00
abstract::Isoliquiritigenin (4,2',4'-trihydroxychalcone, ISL) is a natural pigment with a simple chalcone structure. In this study, we report the ISL-induced inhibition on the growth of human hepatoma cells (Hep G2) for the first time. The cell growth inhibition achieved by ISL treatment resulted in programmed cell death in a c...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2005-837779
更新日期:2005-02-01 00:00:00
abstract::Metabolic fingerprinting techniques have received a lot of attention in recent years and the annual amount of publications in this field has increased significantly over the past decade. This increase in publications is due to improvements in the analytical performance, most notably in the field of NMR and MS analysis...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0029-1185450
更新日期:2009-06-01 00:00:00
abstract::In leaves of CONVALLARIA MAJALIS L. the cardenolide content is known to decrease towards the end of the vegetation period. However, at this stage the rate of biosynthesis is even higher than at the onset of flowering. This has been revealed by photosynthesis experiments in the presence of (14)CO (2) and the subsequent...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2007-969527
更新日期:1985-10-01 00:00:00
abstract::Diabetes mellitus is one of the major health problems in Africa. The conventional oral synthetic antidiabetic drugs available to manage the disease are costly and not readily affordable to the majority of the affected population. Interestingly, the continent is endowed with a tremendous number of medicinal plants that...
journal_title:Planta medica
pub_type: 杂志文章,评审
doi:10.1055/s-0033-1360335
更新日期:2014-03-01 00:00:00
abstract::Hepatocellular carcinoma is one of the leading causes of malignancy-related death in China. Its therapy in clinics is a big challenge. Ginsenoside Rh2 is one of the most notable cancer-preventing components from red ginseng and it has been reported that ginsenoside Rh2 exhibited potent cytotoxicity against human hepat...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-0042-101764
更新日期:2016-05-01 00:00:00
abstract::The phytochemical investigation of the aerial parts of LACTUCA SALIGNA L. revealed the presence of lactucin, lactucopicrin, and a new guaianolide named 11beta,13-dihydrolactucopicrin. The structural configuration was established through spectral data. ...
journal_title:Planta medica
pub_type: 杂志文章
doi:10.1055/s-2006-960064
更新日期:1991-04-01 00:00:00