New antihepatotoxic naphtho-pyrone glycosides from the seeds of Cassia tora.

Abstract:

:Two new naphtho-pyrone glycosides, 9-[(beta-D-glucopyranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]-10- hydroxy-7-methoxy-3-methyl-1H-naphtho[2,3-c]pyran-1 -one (5) and 6-[(alpha-apiofuranosyl-(1----6)-O-beta-D-glucopyranosyl)oxy]- rubrofusarin (6), together with cassiaside (3) and rubrofusarin-6-beta-gentiobioside (4) were isolated from the seeds of Cassia tora L. Their structures were elucidated on the basis of chemical and spectral data. The naphtho-gamma-pyrone glycosides (3, 4, and 6) were found to have significant hepato-protective effects against galactosamine damage, which were higher than that of silybin from Silybum marianum.

journal_name

Planta Med

journal_title

Planta medica

authors

Wong SM,Wong MM,Seligmann O,Wagner H

doi

10.1055/s-2006-962003

subject

Has Abstract

pub_date

1989-06-01 00:00:00

pages

276-80

issue

3

eissn

0032-0943

issn

1439-0221

journal_volume

55

pub_type

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