Abstract:
:Three steroidal saponins, including astrogorgiosides A (1) and B (2) bearing acetamido-glucose moieties, and astrogorgioside C (3) with a 19-nor and bearing an aromatized B ring steroid aglycone, together with a known major saponin dimorphoside A (4), were obtained from the gorgonian Astrogorgia dumbea collected near Dongshan Island in East China Sea. Structures of these compounds were elucidated by in-depth spectral and chemical methods, including 2D-NMR, HR-ESI-MS spectra, and acidic hydrolysis. For the first time, acetamido-glucose moiety is being reported from a gorgonian. The B-ring aromatized steroid aglycone of compound 3 is also rare in marine natural products. Compounds 1-3 exhibited moderate cytotoxic activity with IC50 values of 26.8-45.6 µM against human tumor cells Bel-7402 and K562.
journal_name
Planta Medjournal_title
Planta medicaauthors
Lu YN,Cui P,Tian XQ,Lou LG,Fan CQdoi
10.1055/s-0042-106168subject
Has Abstractpub_date
2016-06-01 00:00:00pages
882-7issue
9-10eissn
0032-0943issn
1439-0221journal_volume
82pub_type
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