Inhibition of chemiluminescence in human PMNs by monocyclic phenolic acids and flavonoids.


:Flavonoids are metabolized in vivo to monocyclic phenolic acids. We investigated whether 18 phenolic acids of the benzoic, phenylacetic, phenylpropanoic or cinnamic series-known or potential metabolites of flavonoids-inhibit reactive oxygen species (ROS) released by human polymorphonuclear neutrophils (PMNs). Chemiluminescence was measured after PMN stimulation with three agents (N-fMetLeuPhe, phorbol myristate acetate (PMA), or opsonised zymosan) using two probes (lucigenin or luminol) with or without horseradish peroxidase (HRP) in order to derive specificity profiles for each test compound. The profiles of the phenolic acids and flavonoids were compared by a multivariate (correspondence) factor analysis. Overall, the phenolic acids were less specific than the flavonoids and, with a few exceptions, less potent. Phenolic acids had virtually no effect on the chemiluminescence related to O2- formation that is measured by lucigenin but inhibited luminol luminescence. Inhibition for all but two phenolic acids was sensitive to HRP and might be explained by a scavenger mechanism. Few structure-activity relationships emerged suggesting that simple properties such as radical scavenging and/or redox activity rather than overall structure might be the key determinants of chemiluminescence inhibition. Whatever the mechanism, however, we conclude that part of the in vivo pharmacological activity of flavonoids may readily be accounted for by phenolic acids.


Planta Med


Planta medica


Limasset B,Ojasoo T,le Doucen C,Doré JC




Has Abstract


1999-02-01 00:00:00












  • Cryptic and free skin irritants of the daphnane and tigliane types in latex of Excoecaria agallocha.

    abstract::In the extremely skin irritant and caustic latex of Excoecaria agallocha the major part of the polyfunctional diterpene esters (DTE) (group I) are aliphatic polyunsaturated 9,13,14-orthoesters of the daphnane-type parent alcohol 5 beta-hydroxyresiniferonol-6 alpha, 7 alpha-epoxide, esterified simultaneously in their 2...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Karalai C,Wiriyachitra P,Opferkuch HJ,Hecker E

    更新日期:1994-08-01 00:00:00

  • Chemical Study on the Alkaloids of Corydalis hsuchowensis.

    abstract::Ten alkaloids were isolated from the bulb of CORYDALIS HSUCHOWENSIS W. Y. Lian nov. ined. Among them nine alkaloids are known, identified as (-)-stylopine ( 1), cheilanthifoline ( 2), (+)-adlumidine ( 3), (+)-bicuculline ( 4), sibiricine ( 5), humosine A ( 6), (+)-bulbocapnine ( 7), (-)-scoulerine ( 8), and protopine ...

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    pub_type: 杂志文章


    authors: Zhou JY,Tong XJ,Lian WY,Fang QC

    更新日期:1991-04-01 00:00:00

  • Dermal pharmacokinetics of Terpinen-4-ol following topical administration of Zingiber cassumunar (plai) oil.

    abstract::The purpose of this study was to investigate dermal pharmacokinetics of terpinen-4-ol in rats following topical administration of plai oil derived from the rhizomes of Zingiber cassumunar Roxb. Unbound terpinen-4-ol concentrations in dermal tissue were measured by microdialysis. The dermal pharmacokinetic study of ter...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Chooluck K,Singh RP,Sathirakul K,Derendorf H

    更新日期:2012-11-01 00:00:00

  • Cytotoxic limonoids from Melia azedarach.

    abstract::Five new compounds (1-5), including two limonoids, one triterpenoid, one steroid, and one sesquiterpenoid, along with nine known limonoids (6-14), were isolated from the bark of Melia azedarach. The structures of the new compounds were elucidated by 2D NMR spectroscopy and mass spectrometry. The isolated compounds as ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Yuan CM,Zhang Y,Tang GH,Li Y,He HP,Li SF,Hou L,Li XY,Di YT,Li SL,Hua HM,Hao XJ

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  • Rodent models of colon carcinogenesis for the study of chemopreventive activity of natural products.

    abstract::This perspective describes some commonly used animal models for the evaluation of potential chemopreventive agents in colon carcinogenesis. Special emphasis is given to the azoxymethane (AOM)/1,2-dimethylhydrazine (DMH) rat model and APCMIN mice, carrying a mutation in APC, a key gene in human carcinogenesis. In the A...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Femia AP,Caderni G

    更新日期:2008-10-01 00:00:00

  • Flavonoids and a sesquiterpene lactone from Tanacetum microphyllum inhibit anti-inflammatory mediators in LPS-stimulated mouse peritoneal macrophages.

    abstract::In our ongoing research into anti-inflammatory compounds from Tanacetum microphyllum, four naturally occurring flavonoids (santin, ermanin, centaureidin and 5,3'-dihydroxy-4'-methoxy-7-methoxycarbonylflavonol) and one sesquiterpene lactone (hydroxyachillin) isolated from this plant, were evaluated as potential inhibit...

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    pub_type: 杂志文章


    authors: Abad MJ,Bermejo P,Alvarez M,Guerra JA,Silván AM,Villar AM

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  • Pharmacokinetics of a Standardized Extract of Centella asiatica ECa 233 in Rats.

    abstract::ECa 233, a standardized extract of Centella asiatica, has been found to exhibit various positive neurological effects and to have a good safety profile. The present study aimed to explore the disposition kinetics of ECa 233, containing madecassoside (53.1 %) and asiaticoside (32.3 %), in rats. The extract was intraven...

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    pub_type: 杂志文章


    authors: Anukunwithaya T,Tantisira MH,Tantisira B,Khemawoot P

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    abstract::Andrographis paniculata contains four major active diterpenoids, including andrographolide (1), 14-deoxy-11, 12-didehydroandrographolide (2), neoandrographolide (3), and 14-deoxyandrographolide (4), which exhibit differences in types and/or degrees of their pharmacological activity. Previous pharmacokinetic studies in...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Pholphana N,Panomvana D,Rangkadilok N,Suriyo T,Ungtrakul T,Pongpun W,Thaeopattha S,Satayavivad J

    更新日期:2016-01-01 00:00:00

  • Antiplatelet Effects of Flavonoids Mediated by Inhibition of Arachidonic Acid Based Pathway.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Karlíčková J,Říha M,Filipský T,Macáková K,Hrdina R,Mladěnka P

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Bacchi EM,Sertié JA

    更新日期:1994-04-01 00:00:00

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    pub_type: 杂志文章


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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Liu Y,Lund JA,Murch SJ,Brown PN

    更新日期:2018-11-01 00:00:00

  • Developmental studies of Artemisia annua: flowering and artemisinin production under greenhouse and field conditions.

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    pub_type: 杂志文章


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    journal_title:Planta medica

    pub_type: 杂志文章


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  • Studies on the endocrine effects of the contents of Cimicifuga racemosa:.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jarry H,Harnischfeger G

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    authors: Vissiennon C,Goos KH,Goos O,Nieber K

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    journal_title:Planta medica

    pub_type: 杂志文章


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    pub_type: 杂志文章


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  • Chemical Varieties of Essential Oils from Elsholtzia polystachya from Two Different Locations in India1.

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  • [Immunologically active glycoproteins of Baptisia tinctoria].

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Beuscher N,Scheit KH,Bodinet C,Kopanski L

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    abstract::We aimed to find antiallergic agents from natural sources using mast cells activated during allergic reaction. We screened over 2000 plants for blockade of histamine release and identified two of them, S. baicalenesis and P. edulis. Bioassay-guided fractionation led to two main constituent flavonoids, baicalin from S....

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Kim DS,Son EJ,Kim M,Heo YM,Nam JB,Ro JY,Woo SS

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    journal_title:Planta medica

    pub_type: 杂志文章


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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ye J,Guan Y,Zeng S,Liu D

    更新日期:2008-02-01 00:00:00

  • Studies on the antihyperlipidemic properties of Averrhoa bilimbi fruit in rats.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Ambili S,Subramoniam A,Nagarajan NS

    更新日期:2009-01-01 00:00:00

  • New antihepatotoxic naphtho-pyrone glycosides from the seeds of Cassia tora.

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wong SM,Wong MM,Seligmann O,Wagner H

    更新日期:1989-06-01 00:00:00

  • Antiplasmodial activity of the alkaloids of Peschiera fuchsiaefolia.

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    journal_title:Planta medica

    pub_type: 信件


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    更新日期:2000-02-01 00:00:00

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Jayaprakasha GK,Murthy KN,Demarais R,Patil BS

    更新日期:2012-06-01 00:00:00

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    journal_title:Planta medica

    pub_type: 历史文章,杂志文章


    authors: Yilmaz A,Nyberg NT,Jaroszewski JW

    更新日期:2012-11-01 00:00:00

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    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang NL,Kiyohara H,Matsumoto T,Otsuka H,Hirano M,Yamada H

    更新日期:1994-10-01 00:00:00

  • Four new lignans from the stems of Kadsura heteroclita.

    abstract::Two new C(18) dibenzocyclooctadiene lignans named heteroclitalignans A and B (1 and 3), one new C(19) homolignan named heteroclitalignan C(4) and one new natural product named heteroclitalignan D(2), together with the four known lignans kadsurarin (5), kadsulignan E (6), d-epigalbacin, and meso-dihydroguaiaretic acid ...

    journal_title:Planta medica

    pub_type: 杂志文章


    authors: Wang W,Liu J,Liu R,Xu Z,Yang M,Wang W,Liu P,Sabia G,Wang X,Guo D

    更新日期:2006-02-01 00:00:00