Activity on the central nervous system of Himanthalia elongata.

Abstract:

:We report the effects of a fraction (F1) obtained from Himanthalia elongata on spontaneous locomotor activity, hypermotility, motor coordination, rectal temperature, pentobarbitone-induced hypnosis, pentylenetetrazole-induced convulsions and analgesic activity in the writhing and hot-plate tests. This fraction caused very significant reductions in spontaneous locomotor activity, hypermotility, and rectal temperature. It postponed pentylenetetrazole-induced death and a slight increase of sleeping time was noted in the sodium pentobarbital-induced sleep test . A significant effect was only noted on motor coordination at high doses. F1 showed significant analgesic effects on the hot-plate test at all of the assayed doses but not on the writhing test, where only the highest dose showed significant activity.

journal_name

Planta Med

journal_title

Planta medica

authors

Anca JM,Lamela M,Calleja JM

doi

10.1055/s-2006-959655

subject

Has Abstract

pub_date

1993-06-01 00:00:00

pages

218-20

issue

3

eissn

0032-0943

issn

1439-0221

journal_volume

59

pub_type

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